Mesker became a professional player in 1981. She reached her highest world rankings with rank 31. At the WTA tournament in Pittsburgh , she won the doubles competition in 1984.
From 1979 to 1987 Mesker played 43 games in the Federation Cup for the Netherlands , of which she was able to win 25.
Today Mesker works as a commentator for the Dutch television station NOS . She is also the owner of a company that organizes various tennis events, including the ATP Challenger tournament in Scheveningen , as well as readings and company events.