Marianne Grunberg-Manago

from Wikipedia, the free encyclopedia

Marianne Grunberg-Manago (born January 6, 1921 in Petrograd , † January 3, 2013 in Paris ) was a French biochemist .

Life

Structure of the PNPase

Grunberg-Manago came from a family of artists and went to France with her family in 1921. She studied biochemistry in Paris and from 1953 was a postdoc in Severo Ochoa's laboratory in New York, where she discovered polynucleotide phosphorylase (PNPase) in 1955 . This was the first enzyme for the direct synthesis of RNA ( RNA polymerases were previously known, but they require DNA) and was used as such by Marshall Nirenberg and Heinrich Matthaei in their classic experiments on the genetic code ( Poly-U experiment ) .

Grunberg-Manago was also involved in the elucidation of various processes involved in the transcription of genes and dealt with biochemical issues relating to the metabolism of bacteria in E. Aubel's laboratory at the Institut de Biologie physicochimique in Paris. In 1967 she became Chef de service there. She was Research Director of the CNRS and Professor at the University of Paris VII from 1977 to 1982 . In 1977 she was visiting professor at Harvard University .

Honors, prizes and memberships (selection)

Web links

personal data
SURNAME Grunberg-Manago, Marianne
BRIEF DESCRIPTION French biochemist
DATE OF BIRTH January 6, 1921
PLACE OF BIRTH Petrograd
DATE OF DEATH January 3, 2013
Place of death Paris