Mosaad Megahed

Mosaad Megahed (born December 10, 1956 in Alexandria , Egypt ) is a German specialist in skin and venereal diseases . He is professor and senior physician at the Department of Dermatology and Allergology at the RWTH Aachen University Hospital . In addition to general dermatology, his scientific focus includes dermatohistology, autoimmune and hereditary blistering diseases, skin cancer and immune-mediated inflammatory skin diseases such as: B. psoriasis , atopic dermatitis , collagenoses , vitiligo and urticaria .

Life

After completing his medical studies, Megahed worked from 1985 to 1990 as an assistant doctor at the University Dermatology Clinic of the Heinrich Heine University in Düsseldorf with Gerd Plewig . In 1990 he was recognized as a specialist in skin and venereal diseases, and a year later he was given the additional qualification in allergology . In 1991 Megahed went to the University of Glasgow for a research stay with Rona MacKie. In the same year he returned to the University Dermatology Clinic in Düsseldorf as a senior physician. In 1994 he received his doctorate in medicine . From 1994 to 1996 he went to Thomas Jefferson University in Philadelphia for a research stay with Jouni Uitto. At the same time, Megahed received further training from Bernie Ackerman at the Institute for Dermatopathology there. In 1996, Megahed completed his habilitation and received the license to teach at the Heinrich Heine University in Düsseldorf, where he worked as a professor and senior physician until 2005. In 2005 he was re- qualified and Megahed was given the license to teach at the University of RWTH Aachen, where he is still professor and senior physician. Megahed has had the additional title of dermatohistology since 2006 and is a specialist examiner at the North Rhine-Westphalia Medical Association.

Scientific contribution

• In 1996 and during his research stay at Thomas Jefferson University in Philadelphia, Megahed and colleagues succeeded in identifying and cloning a new gene in humans and mice. They named the gene LAD and the protein it produced, ladinin. The complete sequence of this gene and its protein is registered in GenBank under the numbers: U42408, O00515 U58994, and U58011.
• In 2002, Megahed and colleagues were able to use immunohistochemistry to show that the melanoma tumor in situ has penetrated deeper into the skin in some cases than had been assessed and therefore has a tendency to metastasize .
• In 2005 Megahed published a monograph on blistering diseases of the skin and mucous membranes.
• In 2008 Megahed cooperated with research teams from various universities and discovered a new disease with skin changes, immune deficiency and RAG mutation.
• In 2014, a doctoral student from Megahed's team was able to show that the melanoma volume plays a role in the melanoma prognosis.

For some years now, Megahed has been focusing on the pathomechanism of therapy resistance in some melanomas and has been cooperating with research teams from the USA in this area.

Memberships in scientific associations

Megahed is a member of the German Dermatological Society , the working groups for dermatological research and dermatological histology and the European Society of Dermatopathology .

honors and awards

In 2003, the Dermatological Histology Working Group (ADH) presented Megahed and colleagues with the KG Steigleder Prize for the best dermatohistology work.

Publications

Books

• M. Megahed: Histopathology of Blistering Diseases: With Clinical, Electron Microscopic, Immunological and Molecular Biological Correlations. Springer Verlag, Berlin / Heidelberg 2004, ISBN 3-540-42562-4 .

items

Megahed published more than 280 publications in scientific journals (as of April 2016).

ResearchGate publication list

Individual evidence

1. ↑ ^{a b} Functional areas of the RWTH Aachen University Hospital
2. ↑ Profile and curriculum vitae of M. Megahed ( Memento of the original from March 4, 2016 in the Internet Archive ) Info: The archive link has been inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. 
3. ↑ MyBioSource Ladin
4. ↑ U42408 GenBank  ( page no longer available , search in web archives )  Info: The link was automatically marked as defective. Please check the link according to the instructions and then remove this notice.  
5. ↑ O00515 NCBI
6. ↑ U58994 GenBank ( Memento of the original from April 25, 2016 in the web archive archive.today ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. 
7. ↑ U58011 GenBank ( Memento of the original from April 25, 2016 in the web archive archive.today ) Info: The archive link was automatically inserted and not yet checked. Please check the original and archive link according to the instructions and then remove this notice. 
8. ↑ M. Megahed, M. Schon, D. Selimovic, MP Schön: Reliability of diagnosis of melanoma in situ. In: Lancet. 359, 2002, pp. 1921-1922.
9. ↑ M. Megahed: Histopathology of Blistering Diseases - With Clinical, Electron Microscopic, Immunological and Molecular Biological Correlations Textbook and Atlas. Springer Verlag, Berlin / Heidelberg 2004, ISBN 3-540-42562-4 .
10. ↑ C. Schuetz, K. Huck, S. Gudowius, M. Megahed, O. Feyen, B. Hubner, DT Schneider, B. Manfras, U. Pannicke, R. Willemze, R. Knüchel, U. Göbel, A. Schulz, A. Borkhardt, W. Friedrich, K. Schwarz, T. Niehues: An Immunodeficiency Disease with RAG Mutations and Granulomas. In: New England Journal of Medicine. 358, 2008, pp. 2030-2038.
11. ↑ B. Voss, S. Wilop, S. Jonas, MHM El-Komy, J. Schaller, V. von Felbert, M. Megahed: Tumor Volume as a Prognostic Factor in Resectable Malignant Melanoma. In: Dermatology. 228, 2014, pp. 66-70.
12. ↑ A. El-Khattouti, D. Selimovic, M. Hannig, EB Taylor, ZY Abd-Elmageed, SY Hassan, Y. Haikel, E. Kandil, M. Leverkus, RT Brodell, M. Megahed, M. Hassan: Imiquimod -induced apoptosis of melanoma cells is mediated by ER stress-dependent noxa induction and enhanced by NF-κB inhibition. In: J Cell Mol Med. 20, 2016, pp. 266-286.
13. ↑ M. Hassan, D. Selimovic, M. Hannig, Y. Haikel, RT Brodell, M. Megahed: Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatment. In: World J Exp Med. 5 (4), Nov 20, 2015, pp. 206-217.
14. ↑ A. El-Khattouti, N. Sheehan, J. Monico, HA Drummond, Y. Haikel, RT Brodell, M. Megahed, M. Hassan: CD133 + melanoma subpopulation acquired resistance to caffeic acid phenethyl ester-induced apoptosis is attributed to the elevated expression of ABCB5: Significance for melanoma treatment. In: . Cancer Lett. 357, 2015, pp. 83-104.
15. ^ European Society of Dermatopathology
16. ↑ KG Steigleder-Preis for M. Megahed ( Memento of the original from April 29, 2016 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice.