Methisazone

Structural formula
General
Non-proprietary name	Metisazon
other names	1-methyl-1 H -indole-2,3-dione-3-thiosemicarbazone N -methylisatin-β-thiosemicarbazone Marborane
Molecular formula	C 10 H 10 N 4 OS
Brief description	orange-yellow powder
External identifiers / databases
CAS number 1910-68-5 EC number 217-616-2 ECHA InfoCard 100.016.016 PubChem 6861563 Wikidata Q4562049
properties
Molar mass	234.27 g · mol -1
Physical state	firmly
Melting point	248 ° C (decomposition)
solubility	practically insoluble in water and dilute inorganic acids
safety instructions
GHS hazard labeling no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Methisazone is an antiviral drug that is effective against smallpox and adenoviruses . Methisazone works by blocking the synthesis of some viral antigens , which creates immature virus particles.

It used to be the only effective chemoprophylaxis for smallpox , and it has been used for this since 1963. With the eradication of smallpox, methisazone has become obsolete.

Individual evidence

1. ↑ ^{a b c} Entry on Metisazon. In: Römpp Online . Georg Thieme Verlag, accessed on May 3, 2015.
2. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
3. ^ FH Meyers: Textbook of Pharmacology. Springer-Verlag, 2013, ISBN 978-3-642-66183-9 , p. 626 ( limited preview in the Google book search).
4. ↑ Eugen Haagen : Viral diseases of humans. Springer-Verlag, 2013, ISBN 978-3-662-26789-9 , pp. 2165-2166 ( limited preview in Google book search).

This article is about a health issue. It is not used for self-diagnosis and does not replace a diagnosis by a doctor. Please note the information on health issues !