N 6 , N 6 -dimethyladenosine

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Structural formula
Structural formula of N6, N6-dimethyladenosine
General
Surname N 6 , N 6 -dimethyladenosine
other names
  • m 6 2 A (short code)
  • 9-β- D- ribofuranosyl-N 6 , N 6 -dimethyladenine
  • 9 - [(2 R , 3 R , 4 S , 5 R ) -3,4-dihydroxy-5- (hydroxymethyl) oxolan-2-yl] -6-dimethylamino-1 H -purine
Molecular formula C 12 H 17 N 5 O 4
External identifiers / databases
CAS number 2620-62-4
EC number 220-057-7
ECHA InfoCard 100.018.235
PubChem 440004
ChemSpider 389022
Wikidata Q15632696
properties
Molar mass 295.29 g mol −1
Physical state

firmly

safety instructions
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

N 6 , N 6 -dimethyladenosine (m 6 2 A) is a rare nucleoside and occurs in the rRNA . It consists of β- D -ribofuranose (sugar) and N 6 , N 6 -dimethyladenine . It is a derivative of adenosine , which isdoubly methylated at the amino group .

Puromycin is a derivative .

Further dimethylated nucleobases are N 2 , N 2 -dimethylguanosine and N 4 , N 4 -dimethylcytidine .

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  2. ↑ Patrick A. Limbach, Pamela F. Crain, James A. McCloskey: "Summary: the modified nucleosides of RNA", Nucleic Acids Research , 1994 , 22  (12), pp. 2183-2196 ( doi : 10.1093 / nar / 22.12 .2183 , PMC 523672 (free full text), PMID 7518580 ).

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