N 6 -methyladenine

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Structural formula
Structural formula of N6-methyladenine
General
Surname N 6 -methyladenine
other names

6-methylamino-purine

Molecular formula C 6 H 7 N 5
External identifiers / databases
CAS number 443-72-1
EC number 207-137-7
ECHA InfoCard 100.006.490
PubChem 67955
ChemSpider 61270
Wikidata Q15632800
properties
Molar mass 149.15 g mol −1
Physical state

firmly

safety instructions
GHS hazard labeling
no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

N 6 -Methyladenine is a heterocyclic organic compound with a purine backbone. It is a derivative of the nucleobase adenine , whichis methylated at the amino group . It occurs as a component of the nucleoside N 6 -methyladenosine  (m 6 A) in RNA and also in bacterial DNA .

Numbering of the purines

The dimethylated variant is N 6 , N 6 -dimethyladenine .

Individual evidence

  1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  2. ↑ D. Ratel, JL Ravanat, F. Berger, D. Wion: "N6-methyladenine: the other methylated base of DNA", Bioessays , 2006 , 28  (3), pp. 309-315 ( PMC 2754416 (free full text) ; PMID 16479578 ).
  3. ↑ Melanie Ehrlich, Miguel A. Gama-Sosa, Laura H. Carreira, Lars G. Ljungdahl, Kenneth C. Kuo, Charles W. Gehrke: "DNA methylation in thermophilic bacteria: N 4 -methylcytosine, 5-methylcytosine, and N 6 -methyladenine ", Nucleic Acids Research , 1985 , 13  (4), pp. 1399-1412 ( doi : 10.1093 / nar / 13.4.1399 ; PMC 341080 (free full text); PMID 4000939 ).