N ⁶ -methyladenosine

Structural formula
General
Surname	N 6 -methyladenosine
other names	m 6 A (short code) 9-β- D -ribofuranosyl- N 6 -methyladenine 9 - [(2 R , 3 R , 4 S , 5 R ) -3,4-dihydroxy-5- (hydroxymethyl) oxolan-2-yl] -6-methylamino-purine
Molecular formula	C 11 H 15 N 5 O 4
External identifiers / databases
CAS number 1867-73-8 PubChem 102175 ChemSpider 92307 Wikidata Q6951996
properties
Molar mass	281.27 g mol −1
Physical state	firmly
safety instructions
GHS hazard labeling no classification available
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

N ⁶ -Methyladenosine (m ⁶ A) is a rare nucleoside and occurs in tRNA , rRNA , mRNA and snRNA . It consists of β- D- ribofuranose (sugar) and N ⁶ -methyladenine . It is a derivative of adenosine , whichis methylated on the amino group .

It is generated enzymatically by methylation of adenosine by means of the N ⁶ adenosine methyl transferase .

The dimethylated variant is N ⁶ , N ⁶ -dimethyladenosine .

Web links

• Entry for N ⁶ -Methyladenosine in the Human Metabolome Database (HMDB) , accessed October 12, 2013.
• Modification Summary of N ⁶ -Methyladenosine in the Modomics database, accessed January 13, 2014.

Individual evidence

1. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
2. ^ Patrick A. Limbach, Pamela F. Crain, James A. McCloskey: Summary: the modified nucleosides of RNA . In: Nucleic Acids Research , 22, 1994. Number 12, pp. 2183-2196 doi : 10.1093 / nar / 22.12.2183 , PMID 7518580 , PMC 523672 (free full text).