Nalbuphine

from Wikipedia, the free encyclopedia
Structural formula
Structure of nalbuphine
General
Non-proprietary name Nalbuphine
other names

(-) - 17- (cyclobutylmethyl) -4,5 α -epoxymorphinan-3,6 α , 14-triol

Molecular formula C 21 H 27 NO 4
External identifiers / databases
CAS number
PubChem 5311304
DrugBank DB00844
Wikidata Q277979
Drug information
ATC code

N02 AF02

Drug class

Opioid - analgesic

properties
Molar mass 357.44 g · mol -1
safety instructions
Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances
06 - Toxic or very toxic

Caution

H and P phrases H: 300-310-330
P: 260-264-280-284-302 + 350-310
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Nalbuphine is a drug belonging to the group of pain relievers of the opioid type. It acts agonistically on the κ- opioid receptors and partially antagonistically on the µ-opioid receptors. The advantages of the partial antagonist are that opioid-related respiratory depression , e.g. B. postoperatively after the use of fentanyl during anesthesia , can be canceled with simultaneous continuation of pain treatment, as nalbuphine itself has an analgesic effect. The analgesic potency compared to morphine is 0.5-0.8. It is similar to pentazocine , but does not increase blood pressure or heart rate. In opiate-dependent patients, however, the use of nalbuphine can cause a withdrawal syndrome immediately after the injection .

Nalbuphine is used as a hydrochloride in injection solutions. The effect occurs quickly after two to three minutes. The half-life is around three hours. Simultaneous administration of treatment with μ-agonistic opioids such as morphine or fentanyl is contraindicated.

Trade names

Monopreparations

Nalpain (D), Nubain (CZ, GR), Generics (A, CH)

literature

  • Wolfgang Forth, Dietrich Henschler, Walter Rummel a. a. (Ed.): General and special pharmacology and toxicology . 8th edition. Urban & Fischer Verlag, Berlin et al. 2001, ISBN 3-437-42520-X , p. 254, 255, 260, 261 .
  • Peter Tonner, Lutz Hein (Hrsg.): Pharmacotherapy in anesthesia and intensive medicine: Fundamentals and clinical concepts . 1st edition. Springer, Berlin / Heidelberg 2011, ISBN 978-3-540-79155-3 , pp. 128 .

Individual evidence

  1. a b Data sheet nalbuphine hydrochloride hydrate from Sigma-Aldrich , accessed on April 12, 2011 ( PDF ).
  2. Product information nalbuphine hydrochloride Orpha-Devel 10 mg / ml solution for injection. As of January 2008.