Narbomycin
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| Non-proprietary name | Narbomycin | |||||||||
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(3 R , 5 R , 6 S , 7 S , 9 R , 11 E , 13 R , 14 R ) -6- [4- (dimethylamino) -3-hydroxy-6-methyloxan-2-yl] oxy-14 -ethyl-3,5,7,9,13-pentamethyl-1-oxacyclotetradec-11-en-2,4,10-trione ( IUPAC ) |
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| Molecular formula | C 28 H 47 NO 7 | |||||||||
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| properties | ||||||||||
| Molar mass | 509.68 g · mol -1 | |||||||||
| Physical state |
firmly |
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| Melting point |
113.5-115 ° C |
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| As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . | ||||||||||
Narbomycin is an antibiotic belonging to the ketolide group . It inhibits protein synthesis in bacteria and is produced by Streptomyces venezuelae .
pharmacology
Narbomycin inhibits bacterial protein synthesis by binding to the 50S subunit of the ribosomes . It interferes with the 23S rRNA of this subunit by binding to domains II and V. In addition, the formation of the 30S and 50S subunits is inhibited.
literature
- S. Piletsky et al. : Custom synthesis of molecular imprinted polymers for biotechnological application Preparation of a polymer selective for tylosin (PDF; 322 kB) . Analytica Chimica Acta , 504 (1), 2004, 123-130. doi : 10.1016 / S0003-2670 (03) 00814-6 .
Individual evidence
- ^ The Merck Index. An Encyclopaedia of Chemicals, Drugs and Biologicals . 14th edition, 2006, p. 1110, ISBN 978-0-911910-00-1 .
- ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
- ↑ Entry on narbomycin in the ChemIDplus database of the United States National Library of Medicine (NLM), accessed on December 9, 2016.
