Non-structural protein 1 (influenza virus A)
| non-structural protein 1 | ||
|---|---|---|
|
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| Dimer , according to PDB 3F5T | ||
| Mass / length primary structure | 230 amino acids , 26 kDa | |
| Secondary to quaternary structure | homodimer | |
| Identifier | ||
| External IDs | ||
The non-structural protein 1 (NS1) of the influenza virus is a protein that during an infection in the course of an immune evasion the immune response reduces.
properties
The non-structural protein 1 does not occur in the virion , which is where the name comes from. NS1 binds to viral RNA and the matrix protein 1 . Furthermore, it binds poly (A) and U6 snRNA NS1 inhibits the proteins CPSF4 and the poly-A-tail binding protein 2 ( PABPN1 ) and inhibits polyadenylation in an infected cell and thus the export of cellular mRNA from the nucleus into the cytosol , whereby comparatively more viral RNA is exported and protein biosynthesis is available. The NS1 has two nuclear localization signals and an essential nuclear export signal for the transport between the cell nucleus and cytosol . NS1 also inhibits protein kinase R and TRIM25 in the course of immune evasion, which reduces the ubiquitination of DDX58 and consequently the induction of type I interferons . This makes NS1 a virulence factor . The NS1 gene lies on the same genomic segment as the NS2 gene .
Individual evidence
- ↑ D. Marc: Influenza virus non-structural protein NS1: interferon antagonism and beyond. In: The Journal of general virology. Volume 95, Pt 12 December 2014, pp. 2594-2611, doi : 10.1099 / vir.0.069542-0 , PMID 25182164 .
- ^ BG Hale: Conformational plasticity of the influenza A virus NS1 protein. In: The Journal of general virology. Volume 95, Pt 10Oktober 2014, pp. 2099-2105, doi : 10.1099 / vir.0.066282-0 , PMID 24928909 .
- ↑ J. Tynell, K. Melén, I. Julkunen: Mutations within the conserved NS1 nuclear export signal lead to inhibition of influenza A virus replication. In: Virology journal. Volume 11, 2014, p. 128, doi : 10.1186 / 1743-422X-11-128 , PMID 25023993 , PMC 4112715 (free full text).
- ↑ J. Ayllon, A. García-Sastre: The NS1 protein: a multitasking virulence factor. In: Current topics in microbiology and immunology. Volume 386, 2015, pp. 73-107, doi : 10.1007 / 82_2014_400 , PMID 25007846 .