Nitrofural

Structural formula
General
Non-proprietary name	Nitrofural
other names	Nitrofurazone; 5-nitro-2-furaldehyde semicarbazone ( IUPAC ); Nitrofuralum ( Latin );
Molecular formula	C 6 H 6 N 4 O 4
External identifiers / databases
EC number	200-443-1
ECHA InfoCard	100,000,403
PubChem	5447130
DrugBank	DB00336
Wikidata	Q425502
Drug information
ATC code	B05 CA03 ; D08 AF01 ; D09 AA03 ; P01 CC02 ; S01 AX04 ; S02 AA02 ;
Drug class	Chemotherapy drugs
properties
Molar mass	198.14 g mol −1
Physical state	firmly
Melting point	242-244 ° C
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances Caution
H and P phrases	H: 302-317
	P: 280
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Nitrofural (trade name Furacin) is a drug from the group of antibiotic nitrofurans . It is used in the local treatment of superficial infected skin diseases and wound infections caused by pathogenic nitrofural-sensitive bacteria.

application

Nitrofural as a crystalline powder.

With nitrofurazone-impregnated urinary catheters , the risk could reduce of catheter-associated urinary tract infections in adult patients. However, it is not used in patients with impaired renal function . Experience with the use in humans is available; the active ingredient is on the market in Germany under the trade name Furacin-SOL. The animal experiment produced indications of embryotoxic / teratogenic effects. Therefore, nitrofural should not be used in pregnant women. It is not known whether the substance is excreted in breast milk , so nitrofural should not be used during breastfeeding.

Side effects

Occasionally, allergic reactions with reddening of the skin and itching are observed.

Individual evidence

↑ ^a ^b ^c data sheet 5-Nitro-2-furaldehyde semicarbazone from Sigma-Aldrich , accessed on July 8, 2017 ( PDF ).
^ Smoot EC Susceptibility testing of topical antibacterials against methicillin-resistant Staphylococcus aureus. In: J Burn Care Rehabil . 1992 Mar-Apr; 13 (2 Pt 1): 198-202, PMID 1587917 .
↑ Evens F et al. Nitrofurazone therapy of Trypanosoma gambiense sleeping sickness in man. In: Am J Trop Med Hyg . 1957 Jul; 6 (4): 665-678, PMID 13458672 .
↑ Stensballe J et al. Infection Risk with Nitrofurazone-Impregnated Urinary Catheters in Trauma Patients: A Randomized Trial . In: Annals of Internal Medicine . 2007 Sep 4; 147 (5): 285-293, PMID 17785483 .
↑ Ballmer-Weber BK Contact allergy to nitrofurazone. In: Contact Dermatitis . 1994; 31 (4): 274-275, PMID 7842698 .

Web links

Commons : Nitrofural - collection of images, videos and audio files

[Sigma-1] ta sheet 5-Nitro-2-furaldehyde semicarbazone from Sigma-Aldrich , accessed on July 8, 2017 ( PDF ).

[2] Smoot EC Susceptibility testing of topical antibacterials against methicillin-resistant Staphylococcus aureus. In: J Burn Care Rehabil . 1992 Mar-Apr; 13 (2 Pt 1): 198-202, PMID 1587917 .

[3] Evens F et al. Nitrofurazone therapy of Trypanosoma gambiense sleeping sickness in man. In: Am J Trop Med Hyg . 1957 Jul; 6 (4): 665-678, PMID 13458672 .

[4] Stensballe J et al. Infection Risk with Nitrofurazone-Impregnated Urinary Catheters in Trauma Patients: A Randomized Trial . In: Annals of Internal Medicine . 2007 Sep 4; 147 (5): 285-293, PMID 17785483 .

[5] Ballmer-Weber BK Contact allergy to nitrofurazone. In: Contact Dermatitis . 1994; 31 (4): 274-275, PMID 7842698 .