Pardis C. Sabeti

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Pardis Christine Sabeti (2013)

Pardis Christine Sabeti (born December 25, 1975 in Tehran, Iran ) is an Iranian-American bioinformatician and medical geneticist . Sabeti is a full professor at the Center for Systems Biology and the Department of Organismic and Evolutionary Biology at Harvard University and the Department of Immunology and Infectious Disease at Harvard TH Chan School of Public Health, and is a member of the Broad Institute and a Howard Hughes Medical Institute Investigator . She is the head of the Sabeti Laboratory. Her research on the Ebola virus outbreak in 2014 made her one of the Person of the Year in TIME Magazine (Ebola Fighters) and one of the most influential people in TIME 100 in 2015.

Career and research

As a PhD student at Oxford and a postdoctoral fellow with Eric Lander at the Broad Institute, Sabeti developed a series of statistical tests that look for common genetic variants found in unusually long haplotypes to identify positive selection . Their tests, Extended Haplotype Homozygosity (EHH), the Long Range Haplotype (LRH) Test, and Cross Population Extended Haplotype Homozygosity (XP-EHH), are designed to detect beneficial mutations that have increased rapidly in frequency in human populations over the past 10,000 years. As a faculty member at Harvard University , Sabeti and her group have developed a statistical test to precisely determine selection signals, the Composite of Multiple Signals (CMS) and a series of statistical tests to identify and characterize correlations in data sets of all kinds, so-called " maximal information non-parametic exploration (MINE) ”.

She developed a bioinformatic statistical method that identifies parts of the genome that are subject to natural selection processes and an algorithm that explains the genetic effects on the development of various diseases. She has contributed to a wide variety of fields in her scientific career - such as virus sequencing, information theory, disease surveillance and education in West Africa - to develop comprehensive approaches to the detection, containment and treatment of deadly infectious diseases.

Research on the Ebola outbreak in West Africa in 2014

In 2014, Sabeti was part of a team led by Christian Happi , a Cameroonian geneticist who used advanced genome sequencing technology to identify a single point of infection from an animal reservoir to a human in the Ebola outbreak in West Africa. Changes in RNA indicate that the first human infection was only followed by human-to-human transmission.

further activities

Sabeti is a participant in the annual Distinguished Lecture Series at MIT's renowned Research Science Institute for high school students. In May 2015, she gave a TED talk entitled "How We Fight the Next Deadly Virus".

Sabeti is a World Economic Forum (WEF) Young Global Leader and a National Geographic Emerging Explorer.

Sabeti is also the lead singer of the rock band Thousand Days and is also the presenter of the educational series "Against All Odds: Inside Statistics" sponsored by Annenberg Learner. This show is featured on many high school statistics curriculum.

Awards

Web links

Commons : Pardis Sabeti  - collection of images, videos and audio files

Individual evidence

  1. ^ Pardis Sabeti. Retrieved December 12, 2019 (American English).
  2. ^ Pardis Sabeti. July 6, 2015, accessed December 12, 2019 .
  3. ^ Sabeti Lab. Retrieved December 12, 2019 (American English).
  4. ↑ a b Pardis C. Sabeti, David E. Reich, John M. Higgins, Haninah ZP Levine, Daniel J. Richter: Detecting recent positive selection in the human genome from haplotype structure . In: Nature . tape 419 , no. 6909 , October 2002, ISSN  0028-0836 , p. 832–837 , doi : 10.1038 / nature01140 ( online [accessed December 12, 2019]).
  5. ^ Sabeti, Pardis. In: The David and Lucile Packard Foundation. Retrieved December 12, 2019 (American English).
  6. ↑ Iranian Scientist Wins NIH 2009 Innovator Award. Retrieved December 12, 2019 .
  7. ↑ Sharon R. Grossman, Ilya Shlyakhter, Ilya Shylakhter, Elinor K. Karlsson, Elizabeth H. Byrne: A composite of multiple signals distinguishes causal variants in regions of positive selection . In: Science (New York, NY) . tape 327 , no. 5967 , February 12, 2010, ISSN  1095-9203 , p. 883-886 , doi : 10.1126 / science.1183863 , PMID 20056855 .
  8. ^ Pardis Sabeti. July 6, 2015, accessed December 12, 2019 .
  9. ↑ The International HapMap Consortium, Pardis C. Sabeti, Patrick Varilly, Ben Fry, Jason Lohmueller: Genome-wide detection and characterization of positive selection in human populations . In: Nature . tape 449 , no. 7164 , October 2007, ISSN  0028-0836 , p. 913–918 , doi : 10.1038 / nature06250 , PMID 17943131 , PMC 2687721 (free full text) - ( online [accessed December 12, 2019]).
  10. ↑ DN Reshef Reshef YA, HK Finucane, SR Grossman, G. McVean: Detecting Novel Associations in large datasets . In: Science . tape 334 , no. 6062 , December 16, 2011, ISSN  0036-8075 , p. 1518–1524 , doi : 10.1126 / science.1205438 , PMID 22174245 , PMC 3325791 (free full text).
  11. ↑ Gina Kolata: The Virus Detectives . In: The New York Times . December 1, 2014, ISSN  0362-4331 ( online [accessed December 12, 2019]).
  12. ^ Daniel J. Park, Gytis Dudas, Shirlee Wohl, Augustine Goba, Shannon LM Whitmer: Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone . In: Cell . tape 161 , no. 7 , June 18, 2015, ISSN  1097-4172 , p. 1516–1526 , doi : 10.1016 / j.cell.2015.06.007 , PMID 26091036 , PMC 4503805 (free full text).
  13. ↑ Single animal to human transmission event responsible for 2014 Ebola outbreak. July 20, 2015, accessed December 12, 2019 .
  14. ^ Pardis Sabeti: How we'll fight the next deadly virus. Retrieved December 12, 2019 .
  15. ^ Pardis Sabeti. July 6, 2015, accessed December 12, 2019 .
  16. ^ Geniuses who will change your life - CNN.com. Retrieved December 12, 2019 .
  17. ^ Resource: Against All Odds: Inside Statistics. Retrieved December 12, 2019 .
personal data
SURNAME Sabeti, Pardis C.
ALTERNATIVE NAMES Sabeti, Pardis Christine (full name)
BRIEF DESCRIPTION Iranian-American bioinformatician and medical geneticist
DATE OF BIRTH December 25, 1975
PLACE OF BIRTH Tehran, Iran