Pipenzolate

Structural formula
	Structure of pipenzolate bromide
General
Non-proprietary name	Pipenzolate
other names	Pipenzolate bromide; 3-Benziloyloxy-1-ethyl-1-methylpiperidinium bromide; (1-Ethyl-1-methylpiperidin-1-ium-3-yl) -2-hydroxy-2,2-diphenyl acetate bromide;
Molecular formula	C 22 H 28 BrNO 3 (bromide) ; C 22 H 28 NO 3 + (anion) ;
External identifiers / databases
EC number	204-741-2
ECHA InfoCard	100.004.311
PubChem	657306
Wikidata	Q27281629
Drug information
ATC code	A03 AB14
Drug class	Antispasmodic
properties
Molar mass	434.37 g · mol -1 (bromide) ; 354.46 g · mol -1 (anion) ;
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances bromide; Caution
H and P phrases	H: 302
	P: no P-phrases
Toxicological data	18 mg kg −1 ( LD 50 , mouse , iv , bromide) ; 1140 mg kg −1 ( LD 50 , mouse , oral , bromide) ; 18 mg kg −1 ( LD 50 , rat , iv , bromide) ; 916 mg kg −1 ( LD 50 , rat , oral , bromide) ;
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Pipenzolat is the non-proprietary name (INN) of a quaternary ammonium compound , which belongs to the group of anticholinergics as a medicinal substance and is used as a spasmolytic in the gastrointestinal tract .

Chemically, it is pipenzolate bromide (trade name: Cholspas Pipenzolat ^® , manufacturer: Dolorgiet ), an active ingredient that was patented by Lakeside in 1959 and is commercially available as a generic .

Extraction

The synthesis takes place starting from benzilic acid and 1-ethyl-3-chloropiperidine with bromomethane .

Individual evidence

↑ ^a ^b Data sheet Pipenzolate bromide from Sigma-Aldrich , accessed on April 21, 2011 ( PDF ).
↑ ^a ^b ^c ^d ^e Kleemann , Engel, Kutscher, Reichert: Pharmaceutical Substances, 4th edition, Thieme-Verlag Stuttgart 2000, page 1649, ISBN 978-1588900319 .
↑ Patent application US2918406 : Anti-spasmodics specific for peptic ulcer. Filed April 8, 1957 , published December 22, 1959 , Applicant: Lakeside Lab Inc., Inventor: John H. Biel. ‌
↑ Entry on pipenzolate bromide. In: Römpp Online . Georg Thieme Verlag, accessed on December 28, 2014.

[Sigma-1] Data sheet Pipenzolate bromide from Sigma-Aldrich , accessed on April 21, 2011 ( PDF ).

[Kleemann-2] Kleemann , Engel, Kutscher, Reichert: Pharmaceutical Substances, 4th edition, Thieme-Verlag Stuttgart 2000, page 1649, ISBN 978-1588900319 .

[3] Patent application US2918406 : Anti-spasmodics specific for peptic ulcer. Filed April 8, 1957 , published December 22, 1959 , Applicant: Lakeside Lab Inc., Inventor: John H. Biel. ‌

[Römpp-4] Entry on pipenzolate bromide. In: Römpp Online . Georg Thieme Verlag, accessed on December 28, 2014.