Platelet-Derived Growth Factor A.
| Platelet Derived Growth Factor, Subunit A. | ||
|---|---|---|
| Properties of human protein | ||
| Mass / length primary structure | 125 amino acids | |
| Secondary to quaternary structure | Homodimer or heterodimer A + B | |
| Precursor | (191 aa) | |
| Isoforms | 125 aa / 110 aa | |
| Identifier | ||
| Gene names | PDGFA ; PDGF-A | |
| External IDs | ||
| Occurrence | ||
| Homology family | PDGF family | |
| Parent taxon | Euteleostomi | |
| Orthologue | ||
| human | mouse | |
| Entrez | 5154 | 18590 |
| Ensemble | ENSG00000197461 | ENSMUSG00000025856 |
| UniProt | P04085 | P20033 |
| Refseq (mRNA) | NM_002607 | NM_008808 |
| Refseq (protein) | NP_002598 | NP_032834 |
| Gene locus | Chr 7: 0.5 - 0.53 Mb | Chr 5: 139.45 - 139.47 Mb |
| PubMed search | 5154 |
18590
|
Platelet-Derived Growth Factor A ( PDGF-A ) is one of four growth factors in the PDGF family. The protein is released from the blood platelets when injured and stimulates new cell growth in the surrounding tissue, and it also plays an important role in the development of the embryo. Mice born without this protein have underdeveloped testes , no Leydig cells and altered sperm ( spermatogenic arrest ).
biosynthesis
The gene coding for the human PDGF-A is located on chromosome 7 and consists of 6 exons that extend over 18,900 base pairs. The 1 431-base-long transcript is in a 211 amino acid protein translated , the (20 amino acids) obtained after removal of the N-terminal signal peptide, the propeptide. After a further 66 amino acids have been cleaved off, the main isoform of PDGF-A results, the other isoform of which lacks the C-terminal 15 amino acids. The two isoforms are thus 125 and 110 amino acids in length.
Biological function
The biological functions of wound stimulation and during embryogenesis are mediated by binding the A + A or A + B dimers to one of the PDGF receptors , which act as a tyrosine kinase .
Individual evidence
- ↑ J. Andrae, L. Gouveia, L. He, C. Betsholtz: Characterization of platelet-derived growth factor-A expression in mouse tissues using a lacZ knock-in approach. In: PloS one. Volume 9, Number 8, 2014, p. E105477, ISSN 1932-6203 . doi : 10.1371 / journal.pone.0105477 . PMID 25166724 . PMC 4148317 (free full text).
- ^ Correction: Characterization of Platelet-Derived Growth Factor-A Expression in Mouse Tissues Using a lacZ Knock-In Approach. In: PloS one. Volume 9, Number 11, 2014, p. E113204, ISSN 1932-6203 . doi : 10.1371 / journal.pone.0113204 . PMID 25383695 . PMC 4226583 (free full text).
- ↑ T. Miyata, T. Toho, N. Nonoguchi, M. Furuse, H. Kuwabara, E. Yoritsune, S. Kawabata, T. Kuroiwa, S. Miyatake: The roles of platelet-derived growth factors and their receptors in brain radiation necrosis. In: Radiation oncology. Volume 9, 2014, p. 51, ISSN 1748-717X . doi : 10.1186 / 1748-717X-9-51 . PMID 24512807 . PMC 3927833 (free full text).