Polyallylamine

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Structural formula
Structural formula polyallylamine
General
Surname Polyallylamine
CAS number 30551-89-4
Monomer Allylamine
Molecular formula of the repeating unit C 3 H 7 N
Molar mass of the repeating unit 57.09 g mol −1
Type of polymer

Thermoplastic

Brief description

yellowish, water-soluble plastic

properties
Physical state

firmly

solubility

very soluble in water

safety instructions
GHS labeling of hazardous substances
no classification available
H and P phrases H: see above
P: see above
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Polyallylamine , abbreviation PAAm or PAH for polyallylamine hydrochloride, is a water-soluble cationic polymer of allylamine .

Manufacturing

Polyallylamine can easily be produced by radical or cationic polymerization of allylamine with different degrees of polymerization .

Properties and use

Polyallylamine is strongly basic and can, for example, bind carbon dioxide . Bound to water-insoluble polymers such as cellulose , it can be used as an anion exchanger with a high loading capacity .

Heavy metal ions such as those of nickel , copper , zinc , cadmium or UO 2 2+ are complexed by polyallylamine in an aqueous solution. This property can be used to separate metal ions by means of polymer-supported membranes.

PAAm is cytotoxic especially to cells of the smooth muscles of the blood vessels . By derivatizing the amino groups, for example by glycation , the cytotoxicity can be significantly reduced. Correspondingly modified PAAm can then be used for gene transfer into cells.

Polyallylamine is a very effective means of immobilizing cells.

As a copolymer with 90 mol%, polyallylamine is the main component of the prescription drug sevelamer [poly (allylamine- co - N , N '-diallyl-1,3-diamino-2-hydroxypropane)], which is used therapeutically as a phosphate binder in dialysis patients with hyperphosphataemia .

Individual evidence

  1. ↑ Poly (allylamine hydrochloride), 95% At: aksci.com. Accessed July 11, 2019
  2. ↑ Poly (allylamine), MW 15000, 15% aq. Soln. Retrieved July 11, 2019 from : www.polysciences.com
  3. ↑ This substance has either not yet been classified with regard to its hazardousness or a reliable and citable source has not yet been found.
  4. ↑ E. Carretti et al: Synthesis and characterization of gels from polyallylamine and carbon dioxide as gellant. In: J. Am. Chem. Soc. 125/2003, pp. 5121-5129. PMID 12708864 .
  5. ^ UJ Kim et al.: Ion-exchange separation of proteins by polyallylamine-grafted cellulose gel. In: Journal of Chromatography A 955/2002, pp. 191-196. PMID 11873976 .
  6. ↑ A. Rether: Development and characterization of water-soluble benzoylthiourea-functionalized polymers for the selective separation of heavy metal ions from wastewater and process solutions. Dissertation, TU Munich, 2002, p. 39.
  7. ↑ S. Kobayashi et al: Poly (allylamine). Chelating properties and resins for uranium recovery from seawater. In: Macromolecules 18/1985, p. 2357.
  8. ^ A. Pathak et al .: Engineered polyallylamine nanoparticles for efficient in vitro transfection. In: Pharm Res . 24/2007, pp. 1427-1440, PMID 17385017 .
  9. ↑ carhunter.com: allylamines accessed on June 26 of 2008.
  10. ↑ O. Boussif et al .: Synthesis of polyallylamine derivatives and their use as gene transfer vectors in vitro. In: Bioconjugate Chemistry 10/1999, pp. 877-883. PMID 10502356 .
  11. ↑ Imanishi: Synthesis of Biocomposite Materials. CRC Press, 1992, p. 248. ISBN 0-849-36771-9 .

literature

  • S. Harada: New Reactive Polymers - with Emphasis on Polyallylamine. 1992
  • GS Kwon: Polymeric Drug Delivery Systems. Informa Health Care, 2005, ISBN 0-824-72532-8 , p. 308
  • IC Kwon et al: Heparin release from polymer complex. In: J Contr Rel 30/1994, pp. 155-159.

Web links