Ronald A. DePinho
Ronald A. "Ron" DePinho (* 1955 in the Bronx , New York ) is an American cancer researcher at the University of Texas MD Anderson Cancer Center .
Live and act
DePinho studied art history and biology at Fordham University (graduated in 1977). He earned an MD from Albert Einstein College of Medicine in 1981 with a degree in medicine (with honors in microbiology and immunology ). In 1984 he became a specialist in internal medicine . From 1984 to 1988 he worked as a postdoctoral fellow with Matthew D. Scharff and Frederick Alt at the Albert Einstein College of Medicine, where he was also appointed professor in 1988. From 1988 to 1997 he also worked as a doctor at Jacobi Hospital in the Bronx .
After a professorship at Harvard Medical School and work at the Dana-Farber Cancer Institute (1998–2011), he is now Professor of Tumor Biology at the University of Texas MD Anderson Cancer Center , of which he was President from 2011 to 2017.
Ronald DePinho uses mice as a model organism . He was able to make numerous fundamental contributions to the understanding of tumor biology (some with references to aging or degenerative diseases ). He was able to show that p53 acts as a tumor suppressor by activating apoptosis when the cell cycle is defective , and that INK4a / ARF is a real tumor suppressor. He also clarified the links between the ARF and the p53 pathway and its role in protecting against environmental carcinogens . His work on telomerase shed light on why age is such a powerful carcinogen and paved the way for the use of telomerase inhibitors as cancer drugs. DePinho also established the tumor maintenance model .
DePinho has (as of December 2018) an h-index of 162. He is married and has three children.
Awards (selection)
- 2002 ASCI Award from the American Society for Clinical Investigation
- 2004 member of the Institute of Medicine
- 2007 Harvey Lecture
- 2009 Szent-Györgyi Prize of the National Foundation for Cancer Research
- 2010 member of the American Academy of Arts and Sciences
- 2012 member of the National Academy of Sciences
- 2014 Fellow of the American Association for the Advancement of Science
Web links
- Ronald A. DePinho, MD at the University of Texas MD Anderson Cancer Center (mdanderson.org)
- Ronald A. DePinho, MD at academictree.org
literature
- M. Landau: An Interview with Ronald DePinho. In: Clinical Chemistry. 59, 2013, p. 11, doi : 10.1373 / clinchem.2012.184911 .
- Prashant Nair: QnAs with Ronald DePinho :. In: Proceedings of the National Academy of Sciences . 110, 2013, p. 14508, doi : 10.1073 / pnas.1311541110 .
Individual evidence
- ^ MD Anderson's Past Presidents. In: mdanderson.org. MD Anderson Cancer Center , accessed December 28, 2018 .
- ↑ Ronald A. DePinho. In: scholar.google.de. Google Scholar , accessed December 28, 2018 .
- ^ The 2002 ASCI Award: Ronald A. DePinho, MD. In: the-asci.org. American Society for Clinical Investigation , accessed December 28, 2018 .
- ^ Modeling Cancer and Cancer Genomes - Ronald A DePinho, MD. In: harveysociety.org. Harvey Society, November 15, 2007, accessed December 28, 2018 .
- ↑ 2009 Prize: Ronald A. DePinho, MD In: nfcr.org. National Foundation for Cancer Research, accessed December 28, 2018 .
- ↑ Book of Members 1780 – present, Chapter D. (PDF; 575 kB) In: American Academy of Arts and Sciences (amacad.org). Retrieved December 27, 2018 .
- ↑ Ronald A. DePinho. In: nasonline.org. National Academy of Sciences , accessed December 28, 2018 .
| personal data | |
|---|---|
| SURNAME | DePinho, Ronald A. |
| ALTERNATIVE NAMES | DePinho, Ronald; De Pinho, Ronald; DePinho, Ron |
| BRIEF DESCRIPTION | American cancer researcher |
| DATE OF BIRTH | 1955 |
| PLACE OF BIRTH | Bronx , New York |