Sec61 Translocon β

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Sec61 Translocon β
other names

Sec61β

Mass / length primary structure 96 amino acids , 9,974 Da
Identifier
External IDs
Orthologue
human House mouse
Entrez 10952 66212
Ensemble ENSG00000106803 ENSMUSG00000053317
UniProt P60468 Q9CQS8
Refseq (mRNA) NM_006808 NM_024171
Refseq (protein) NP_006799 NP_077133
PubMed search 10952 66212

Sec61 Translocon β (synonym Sec61β, Sec61B) is a transmembrane protein in vertebrates . It is part of the translocon (Sec61 translocon) for the import of proteins with K D E L - signal sequence from the cytosol into the endoplasmic reticulum .

properties

Sec61 is a heterotrimer in vertebrates and consists of the three proteins Sec61 Translocon α1 ( Sec61A1 ), Sec61B and Sec61G . Sec61 forms a pore with a closure that is opened for proteins with KDEL signal sequence. After translation , the methionine is split off at position 1. It is palmitoylated at the cysteine at position 39 .

literature

  • E. Hartmann, T. Sommer, S. Prehn, D. Görlich, S. Jentsch, TA Rapoport: Evolutionary conservation of components of the protein translocation complex. In: Nature . Volume 367, Number 6464, February 1994, pp. 654-657, doi : 10.1038 / 367654a0 , PMID 8107851 .
  • JJ Greenfield, S. High: The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment. In: Journal of cell science. Volume 112 (Pt 10), May 1999, pp. 1477-1486, PMID 10212142 .

Individual evidence

  1. ↑ a b c Uniprot : P60468 .
  2. ↑ 10952 - Gene ResultSEC61B SEC61 translocon beta subunit (human). In: ncbi.nlm.nih.gov. Retrieved October 5, 2019 .