Sec61 Translocon γ
| Sec61 Translocon γ | ||
|---|---|---|
| other names |
Sec61β |
|
| Mass / length primary structure | 68 amino acids , 7,741 Da | |
| Identifier | ||
| External IDs | ||
| Orthologue | ||
| human | House mouse | |
| Entrez | 23480 | - |
| Ensemble | ENSG00000132432 | - |
| UniProt | P60059 | - |
| Refseq (mRNA) | NM_014302 | - |
| Refseq (protein) | NP_055117 | - |
| PubMed search | 23480 |
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Sec61 Translocon γ (synonym Sec61γ, Sec61G) is a transmembrane protein in vertebrates . It is part of the translocon (Sec61 translocon) for the import of proteins with K D E L - signal sequence from the cytosol into the endoplasmic reticulum .
properties
Sec61 is a heterotrimer in vertebrates and consists of the three proteins Sec61 Translocon α1 ( Sec61A1 ), Sec61B and Sec61G. Sec61 forms a pore with a closure that is opened for proteins with KDEL signal sequence. After translation , the methionine is acetylated at the 1 position . It is phosphorylated at the serine at position 18 .
literature
- E. Hartmann, T. Sommer, S. Prehn, D. Görlich, S. Jentsch, TA Rapoport: Evolutionary conservation of components of the protein translocation complex. In: Nature . Volume 367, Number 6464, February 1994, pp. 654-657, doi : 10.1038 / 367654a0 , PMID 8107851 .
- JJ Greenfield, S. High: The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment. In: Journal of cell science. Volume 112 (Pt 10), May 1999, pp. 1477-1486, PMID 10212142 .