Sterol delta 8/7 isomerase

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3-β-hydroxysteroid Δ8,7 isomerase
other names
  • Cholstenol Δ isomerase
  • Δ8, Δ7 sterol isomerase
  • D8, D7 sterol isomerase
  • Emopamil binding protein
Properties of human protein
Mass / length primary structure 26.4 kilodaltons / 230 amino acids
Secondary to quaternary structure multipass membrane protein (ER)
Gene name EBP
External IDs
Enzyme classification
EC, category isomerase
Response type Rearrangement
Substrate Delta (8) sterol
Products Delta (7) sterol
Parent taxon Eukaryotes
human House mouse
Entrez 10682 13595
Ensemble ENSMUSG00000031168
UniProt Q15125 P70245
Refseq (mRNA) NM_006579 NM_007898
Refseq (protein) NP_006570 NP_031924
Gene locus Chr X: 48.52 - 48.53 Mb Chr X: 8.19 - 8.19 Mb
PubMed search 10682 13595

The sterol Δ8 / 7-isomerase (also: emopamil binding protein (EBP) ) is the enzyme , the sterol derivatives within the rearrangement of the located in the 8-position double bond in the 7-position catalyzed . This reaction takes place in all eukaryotes within the framework of cholesterol biosynthesis . It is a transmembrane protein that is located on the endoplasmic reticulum . Mutations in EBP - gene of humans are the cause of a type of chondrodysplasia punctata , called Conradi-Hünermann syndrome .

Catalyzed reaction


Zymosterol is rearranged to 5α-Cholesta-7,24-dien-3β-ol.

Individual evidence

  1. Homologues at inParanoid
  2. UniProt Q15125

Web links