Stuart A. Aaronson

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Stuart Aaronson

Stuart A. Aaronson (born February 28, 1942 in Mount Clemens , Michigan ) is an American cancer researcher.

Aaronson received his bachelor's degree in chemistry from the University of California at Berkeley in 1962 and his doctorate in medicine from the Medical School of the University of California at San Francisco (MD) in 1966 . He then went to the University of Cambridge on a scholarship and did his internship at Moffitt Hospital in San Francisco. From 1967 he was in the field of cancer viruses (Viral Cancerogenesis) at the National Institutes of Health , from 1969 as Senior Staff Fellow and from 1970 to 1977 as head of the molecular biology department in the area of ​​cancer virus research. He then headed the Cell and Molecular Biology Laboratory at the National Cancer Institute . In 1993 he became Chairman of the Oncological Sciences at Mount Sinai Medical Center (Director of the Derald H. Ruttenberg Cancer Center), where he is Jane B. and Jack R. Aron Professor of Neoplastic Diseases.

From 1984 to 1987 he was a scientific advisor to the American Cancer Society. In 1981 he became co-editor of Cancer Research . He is the author of over 530 scientific articles (2010) and holds over 50 patents.

Aaronson made important discoveries about oncogenes , partly with the help of a cDNA cloning technique he developed (stable expression cDNA cloning). He and colleagues discovered the first normal functioning of an oncogene in v-sis as a growth factor in cell communication. He discovered erbB2 as a gene that is more active in breast cancer and discovered the epithelial cell- specific growth factor KGF (Keratinocyte Growth Factor, FGF7) and its role in wound healing, which led to the development of the drug Kepivance (by Amgen ), for example against oral mucositis . Together with colleagues, he discovered that the MET, encoded in proto-oncogenes, is a receptor for HGF / SF (heptatocyte growth factor / scatter factor).

Awards

  • 1982 Rhoads Memorial Award from the American Association of Cancer Research
  • 1982 USPHS (US Public Health Service) Meritorious Service Medal
  • 1989 Paul Ehrlich and Ludwig Darmstädter Prize
  • 1989 USPHS Distinguished Service Medal
  • 1990 Milken Award
  • 1991 Chirone Prize
  • 1991 Harvey Lecture
  • 1991 Wadsworth Memorial Foundation Award

Web links

Individual evidence

  1. ↑ Date of birth and career dates from American Men and Women of Science , Thomson Gale 2004
personal data
SURNAME Aaronson, Stuart A.
BRIEF DESCRIPTION American oncologist
DATE OF BIRTH February 28, 1942
PLACE OF BIRTH Mount Clemens , Michigan