Sulfaguanidine

Structural formula
General
Non-proprietary name	Sulfaguanidine
other names	4-amino- N - (diaminomethylene) benzenesulfonamide; 4-amino- N - (diaminomethylene) benzenesulfonamide; 4-amino- N - (aminoiminomethyl) benzenesulfonamide;
Molecular formula	C 7 H 10 N 4 O 2 S
Brief description	White dust
External identifiers / databases
EC number	200-345-9
ECHA InfoCard	100,000,314
PubChem	5324
ChemSpider	5133
Wikidata	Q414886
Drug information
ATC code	Q A07AB03
properties
Molar mass	214.24 g mol −1
Physical state	firmly
Melting point	190–193 ° C (monohydrate)
solubility	slightly soluble in water: 1 g l −1 (25 ° C); slightly soluble in alcohol and acetone; insoluble in caustic soda;
safety instructions
	Please note the exemption from the labeling requirement for drugs, medical devices, cosmetics, food and animal feed
GHS labeling of hazardous substances Caution
H and P phrases	H: 315-319-335
	P: 261-305 + 351 + 338
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Sulfaguanidine is a chemical compound belonging to the sulfonamide group .

properties

Sulfaguanidine is a white powder that gradually changes color in air.

use

Sulfaguanidine is used as a representative of the sulfonamides as an antibiotic in veterinary medicine (rarely). These compounds have an inhibitory effect on the intracellular folic acid synthesis of microorganisms and have a bacteriostatic effect after a latency period of 4 to 6 hours.

Pharmacological properties

Sulfaguanidine is one of the sulfonamides that are difficult to absorb orally and only has an effect on bacterial pathogens locally in the gastrointestinal tract .

Individual evidence

↑ ^a ^b ^c data sheet sulfaguanidines from Sigma-Aldrich , accessed on April 23, 2011 ( PDF ).
↑ ^a ^b ^c ^d ^e ^f Entry on sulfaguanidine at Vetpharm, accessed on July 29, 2012.
^ Hermann Hager, Franz von Bruchhausen: Hagers Handbook of Pharmaceutical Practice , Volume 5, p. 596; ISBN 978-3-540-62646-6 .

[Sigma-1] ta sheet sulfaguanidines from Sigma-Aldrich , accessed on April 23, 2011 ( PDF ).

[vet-2] ↑ ^a ^b ^c ^d ^e ^f Entry on sulfaguanidine at Vetpharm, accessed on July 29, 2012.

[3] Hermann Hager, Franz von Bruchhausen: Hagers Handbook of Pharmaceutical Practice , Volume 5, p. 596; ISBN 978-3-540-62646-6 .