Suzanne Eaton

from Wikipedia, the free encyclopedia

Suzanne Eaton (born December 23, 1959 in Oakland , California - † July 2, 2019 in Crete ) was an American molecular biologist who lived and worked in Germany.

Life

Eaton was the daughter of an electrical engineer who taught at the University of California, Berkeley , and later worked in the research department of IBM . After finishing school, Eaton took a gap year and worked, among other things, as a technician in a hospital. She then studied biology at Brown University until 1981 and worked as a tutor for immunology at the University of California, Los Angeles (UCLA) from 1981 to 1983 , where she received her PhD in microbiology under Kathryn Calame in 1988 . For her work she was awarded the Sydney C. Rittenberg Award for Distinguished Academic Achievement in Microbiology.

From 1988 to 1993 Eaton worked as a postdoc at UCLA with Thomas B. Kornberg , studying Drosophila melanogaster . She then continued her research - until 1997 as a postdoc - at the European Molecular Biology Laboratory in Heidelberg in Kai Simons' research group, with a focus on cell biology and developmental biology.

Eaton came to the Max Planck Institute for Molecular Cell Biology and Genetics (MPI-CBG) in 2000 , where she headed her own scientific working group from 2001. From 2015 she held the professorship for Developmental Cell Biology of Invertebrates at BIOTEC at TU Dresden ; the appointment was made together with the MPI-CBG.

Eaton's main research interests included tissue mechanics and tissue development (including studies on the morphogens Hedgehog and Wingless ). One of her research successes was the discovery of so-called “argosomes”, transporter lipoproteins, with the help of which morphogens, for example, can travel long distances between cells in organisms. The results were published in the journal Nature in 2005 under the title Lipoprotein particles are required for Hedgehog and Wingless signaling .

Eaton was married to the British scientist Anthony A. Hyman ; the couple has two sons.

During a conference in Crete , Eaton disappeared; she was last seen alive on July 2 and found dead in a cave on July 8, 2019. The Greek police opened a murder investigation; the alleged perpetrator, a 27-year-old farmer and married family man, was caught by the police and confessed.

Publications (selection)

  • Suzanne Eaton, Kathryn Calame: Multiple DNA Sequence Elements are Necessary for the Function of an Immunoglobulin Heavy Chain Promoter . Proceedings of the National Academy of Sciences of the United States of America, No. 84, 1987, pp. 7634-7638.
  • Anton Rietveld, Stephanie Neutz, Kai Simons, Suzanne Eaton: Association of Sterol- and Glycosylphosphatidylinositol-linked Proteins with Drosophila RaftLipid Microdomains . In: Journal of Biological Chemistry , No. 274, 1999, pp. 12049-12054.
  • Daniela Panáková, Hein Sprong, Eric Marois, Christoph Thiele, Suzanne Eaton: Lipoprotein particles are required for Hedgehog and Wingless signaling . In: Nature , No. 435, 2005, pp. 58-65.
  • Eric Marois, Suzanne Eaton: RNA in the hedgehog signaling pathway: pFRiPE, a vector for temporally and spatially controlled RNAi in Drosophila . In: Jamila I. Horabin (Ed.): Hedgehog signaling protocols . Humana Press, Totowa 2007, pp. 115-128.
  • Marta M. Swierczynska, Valéria Lamounier-Zepter, Stefan R. Bornstein, Suzanne Eaton: Lipoproteins and Hedgehog signaling - possible implications for the adrenal gland function . In: European Journal of Clinical Investigation , 2013.
  • Wilhelm Palm, Marta Maria Świerczyńska, Veena Kumari, Monika Ehrhart-Bornstein, Stefan R. Bornstein, Suzanne Eaton: Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals . PLoS Biol, Vol. 11, No. 3, 2013, p. E1001505.
  • Jonathan Rodenfels, Oksana Lavrynenko, Sophie Ayciriex, Julia L. Sampaio, Maria Carvalho, Andrej Shevchenko, Suzanne Eaton: Production of systemically circulating Hedgehog by the intestine couples nutrition to growth and development . Genes and Development, No. 28 (23), 2014 pp. 2636-2651.
  • Helena Khaliullina, Mesut Bilgin, Julia L. Sampaio, Andrej Shevchenko, Suzanne Eaton: Endocannabinoids are conserved inhibitors of the Hedgehog pathway . In: Proceedings of the National Academy of Sciences, No. 112, 2015, pp. 3415-3420.
  • Frank Jülicher , Suzanne Eaton: Emergence of tissue shape changes from collective cell behaviors 2016, doi: 10.1016 / j.semcdb.2017.04.004 .
  • Matthias Merkel, Raphaël Etournay, Marko Popović, Guillaume Salbreux, Suzanne Eaton, Frank Jülicher: Triangles bridge the scales: Quantifying cellular contributions to tissue deformation . Physical Review E; No. 93, Issue 3, 2017, pp. 32401–32424.

literature

  • Caitlin Sedwick: Suzanne Eaton: The beautiful logic of development . In: The Journal of Cell Biology , Vol. 202 (2013), No. 2, pp. 184-185.

Web links

Individual evidence

  1. ↑ a b Profile of Suzanne Eaton on mpi-cbg.de , accessed on July 6, 2019.
  2. ^ Obituary for Suzanne Eaton . mpg.de, July 22, 2019.
  3. ^ A b c Caitlin Sedwick: Suzanne Eaton: The beautiful logic of development . In: The Journal of Cell Biology , Vol. 202, No. 2, p. 184.
  4. ↑ To distant worlds. Suzanne Eaton has found vans that can penetrate all corners of the body . In: Sächsische Zeitung , April 23, 2005, p. M2.
  5. ^ ASCB Profile: Tony Hyman . In: ASCB Newsletter, November 2012, p. 41 ( online ).
  6. ^ Statement on the tragic demise of Suzanne Eaton . mpi-cbg.de, July 9, 2019.
  7. ^ Dead biologist from Dresden: Police in Crete do not rule out crimes. , Dresdner Latest News from July 9, 2019, accessed on July 10, 2019.
  8. ↑ Suzanne Eaton murder case: Researcher was hit, raped and killed in Crete. In: Der Tagesspiegel , July 16, 2019, accessed on July 20, 2019
personal data
SURNAME Eaton, Suzanne
BRIEF DESCRIPTION American molecular biologist
DATE OF BIRTH December 23, 1959
PLACE OF BIRTH Oakland , California
DATE OF DEATH 2nd July 2019
Place of death Crete