Thrombocytopathy
| Classification according to ICD-10 | |
|---|---|
| D69.1 | Thrombocytopathy |
| ICD-10 online (WHO version 2019) | |
A thrombocytopathy even thrombopathies called, is a disorder of platelets (platelets).
description
The dysfunction of the platelets can be expressed by aggregation , spreading or adhesion. The number of platelets, on the other hand, is normal or only slightly changed (differentiated from thrombocytopenia ). Thrombocytopathy is a special form of hemorrhagic diathesis .
Platelets are cell components in the blood that play an important role in blood clotting . Correspondingly, thrombocytopathy leads to an increased readiness for bleeding, such as nosebleeds , bleeding gums , long bleeding cuts. Also petechial bleeding are possible. The mucosal bleeding time is prolonged.
Both exogenous (external) and endogenous (internal) influences can be responsible for thrombocytopathy.
Exogenous causes
A number of drugs , such as acetylsalicylic acid , diclofenac , heparin , penicillin and various chemotherapeutic agents , limit the function of the platelets.
Endogenous causes
A number of hereditary syndromes can cause thrombocytopathy
- Willebrand-Juergens Syndrome (more like coagulopathy)
- Bernard Soulier Syndrome
- Glanzmann's thrombasthenia (hereditary thrombasthenia)
- Storage pool disease (reduction of the dense granules with disturbance of the irreversible platelet aggregation); Type I (d-granules), type II (a-granules), type III (d- and a-granules)
- Giant platelet thrombocytopathy (lack of binding site for von Willebrand factor)
- Aspirin-like defect
therapy
Therapy is usually only given when clinically indicated, for example with desmopressin .
literature
- S2k guideline thrombocytopathies of the Society for Thrombosis and Haemostasis Research (GTH). In: AWMF online (as of 2012)
- S2k guideline Thrombocytopathies, Therapies of the Society for Thrombosis and Haemostasis Research (GTH). In: AWMF online (as of 2014)
- E. Lindhoff-Last: Die Gynäkologie , Springer Berlin Heidelberg, 2006, pp. 245-54 ISBN 978-3-540-25664-9
- H. Riess, E. Seifried: Acquired hemorrhagic diatheses . In: Rational diagnostics and therapy in internal medicine - guidelines. Editors Classen M, Dierkesmann R, Heimpel H, Koch KM, Meyer J, Müller OA, Specker C, Theiss W for the German Society for Internal Medicine, 2004 Chapter B 28
Web links
- Charité: Institute for Transfusion Medicine ( Memento from July 2, 2007 in the Internet Archive )
Individual evidence
- ↑ D. Gengenbacher et al. a .: Bernard-Soulier thrombocytopathy: clinical significance of a rare disease. In: Schweiz Med Wochenschrift 126/1996, pp. 1834–1841.
