Toxic dose

In pharmacology and toxicology , the toxic dose denotes a dose that causes one or more toxic effects in living beings . The toxic dose is defined analogously to the lethal dose , the radiation dose and the infectious dose .

properties

The toxic dose is generally below the lethal dose and above the NOAEL . For drugs to be approved, the effective dose for a treatment must be below the toxic dose, which is described by the therapeutic range . Since the toxicity of a substance is subject to many different influences, such as If, for example, the general state of health of the cell culture , the test animal or the test person is subject, a sigmoid dose-toxicity curve is often shown . Therefore, the minimum toxic dose in the course of the statistical evaluation is usually given with the index 50 as TD ₅₀ , i.e. the toxic dose at which 50% of the cell cultures, test animals or test persons exhibit toxic effects. The lowest known toxic dose is below the TD ₅₀ .

literature

• Aktories, Klaus ; Förstermann, Ulrich; Hofmann, Franz; Starke, Klaus (Ed.): General and special pharmacology and toxicology. (Founded by W. Forth, D.Hentschler and W. Rummel), Urban & Fischer, Munich, Jena, 9th edition 2005, ISBN 3-437-42521-8 .
• Hunnius, Curt ; Ammon, HPT : Hunnius - Pharmaceutical Dictionary . de Gruyter, Berlin 2004, ISBN 978-3-11-017475-5 .

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