Klaus Aktories

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Klaus Aktories (born August 4, 1948 in Wanne-Eickel ) is a German physician and pharmacologist . His research interests are in signal transduction by GTPases and their interaction with bacterial toxins .

Life

Aktories studied pharmacy and medicine in Frankfurt am Main . Under the guidance of Hans-Dieter Taubert , he wrote his dissertation The Influence of Different Types of Hormonal Contraceptives on the Ovarian Cycle and was awarded a Dr. med. PhD . At the Ruprecht-Karls-Universität Heidelberg he was awarded a Dr. rer. nat. PhD ("Inhibition of fat cell adenylate cyclase by hormonal factors and drugs"). From 1981 to 1984 Aktories worked with Günter Schultz at the Pharmacological Institute of Heidelberg University and completed his habilitation in 1983 on the subject of hormone-sensitive GTPases - studies on the regulation and role of GTPases in the hormonal control of adenylate cyclase .

From 1985 to 1989 and 1989 to 1991 Aktories held an extraordinary professorship in Gießen and Essen. In 1991 he switched to a full professorship at Saarland University . In 1995 he was selected from 57 applicants for Chair I at the Institute for Experimental and Clinical Pharmacology and Toxicology at the University of Freiburg and appointed.

plant

The work of Klaus Aktories contributes significantly to the understanding of the mode of action of bacterial protein toxins. In 1986 he and his colleagues were able to show that the botulinum C2 toxin destroys the polymer structure of actin through ADP ribosylation. The Clostridium difficile toxins A and B, the zyototoxic-necrotizing factor 1 from E. coli strains and the toxins from Photorhabdus luminescens also lead to a destruction of the cytoskeleton via modification of Rho-GTPases .

An overview article published in 2005 gives a deeper insight into Klaus Aktories' research.

Together with others, Aktories is the publisher of the German-language standard work General and Special Pharmacology and Toxicology founded by Wolfgang Forth .

Awards

Individual evidence

  1. ↑ a b c Klaus Starke : The history of the pharmacological institute of the University of Freiburg. 2nd Edition; 2007 PDF file.
  2. ↑ a b c CV of Klaus Aktories at the Institute for Experimental and Clinical Pharmacology and Toxicology at the University of Freiburg , accessed on December 31, 2010
  3. ↑ K. Aktories, M. Bärmann, I. Ohishi, S. Tsuyama, KH Jakobs, E. Habermann: Botulinum C2 toxin ADP-ribosylates actin. In: Nature . Volume 322, Number 6077, 1986 Jul 24-30, pp. 390-392, ISSN  0028-0836 . doi : 10.1038 / 322390a0 . PMID 3736664 .
  4. ^ I. Just, J. Selzer, M. Wilm, C. von Eichel-Streiber, M. Mann, K. Aktories: Glucosylation of Rho proteins by Clostridium difficile toxin B. In: Nature. Volume 375, Number 6531, June 1995, pp. 500-503, ISSN  0028-0836 . doi : 10.1038 / 375500a0 . PMID 7777059 .
  5. ↑ G. Schmidt, P. Sehr, M. Wilm, J. Selzer, M. Mann, K. Aktories: Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1. In: Nature. Volume 387, Number 6634, June 1997, pp. 725-729, ISSN  0028-0836 . doi : 10.1038 / 42735 . PMID 9192900 .
  6. ^ AE Lang, G. Schmidt, A. Schlosser, TD Hey, IM Larrinua, JJ Sheets, HG Mannherz, K. Aktories: Photorhabdus luminescens toxins ADP-ribosylate actin and RhoA to force actin clustering. In: Science . Volume 327, Number 5969, February 2010, pp. 1139-1142, ISSN  1095-9203 . doi : 10.1126 / science.1184557 . PMID 20185726 .
  7. ↑ K. Aktories, JT Barbieri: Bacterial cytotoxins: targeting eukaryotic switches. In: Nature reviews. Microbiology. Volume 3, Number 5, May 2005, pp. 397-410, ISSN  1740-1526 . doi : 10.1038 / nrmicro1150 . PMID 15821726 . (Review).
  8. ↑ K. Aktories, U. Förstermann, F. Hofmann and K. Starke: General and special pharmacology and toxicology. 10th edition. Munich, Elsevier 2009. ISBN 978-3-437-42522-6 .
  9. ^ Member entry by Klaus Aktories at the German Academy of Sciences Leopoldina , accessed on October 12, 2012.
  10. ^ List of the Feldberg Foundation winners , accessed on December 31, 2010
  11. ^ Membership directory of the European Molecular Biology Organization , accessed on December 31, 2010
personal data
SURNAME Aktories, Klaus
BRIEF DESCRIPTION German physician and pharmacologist
DATE OF BIRTH 4th August 1948
PLACE OF BIRTH Wanne-Eickel