Ulrich Dirnagl

Ulrich Dirnagl (2015)

Ulrich Dirnagl (born August 9, 1960 in Munich ) is a German neurologist . Since September 1999 he has been director of the Experimental Neurology Department at the Charité Universitätsmedizin Berlin.

Life

Ulrich Dirnagl studied medicine at the Ludwig Maximilians University in Munich (LMU) from 1980 to 1988 and worked there as a research assistant in the Department of Neurology. During this time he did his doctorate on the subject of "Etiology and significance of the 0.5-2 / minute oscillations of intracranial pressure " which was supervised by Karl Max Einhäupl . Between 1988 and 1989 he did research at Cornell University in the United States and then returned to Munich, where he worked as a research assistant at the neurological clinic of the University of Munich. In 1993 he moved to Berlin, where he worked as a senior physician in the neurological clinic at the Charité . During this time he began to set up a research laboratory "Experimental Neurology" whose focus should be to represent a bridge between basic research in neurosciences on the one hand and clinical neurology on the other.

His habilitation in experimental neurology took place in December 1993 at the LMU. In 1999, with the help of the Herrmann and Lilly Schilling Foundation for Medical Research, the Department of Experimental Neurology was established and a chair for Experimental Neurology was set up, to which Ulrich Dirnagl was appointed. The Department of Experimental Neurology is still headed by him today. In addition, Ulrich Dirnagl is active in a large number of initiatives and programs.

Research priorities

In the field of experimental neurology, Ulrich Dirnagl's research focuses on the following areas:

• Physiology and pathophysiology of the regulation of cerebral blood flow
• Stroke Pathology
• Brain imaging

Another focus of Ulrich Dirnagl's work is the investigation of the research itself, especially stroke research. He tries to answer the question why promising results of basic research can only rarely be reproduced in clinical studies , a prerequisite for future affected patients. In a number of publications he argues that poor quality standards in basic research, e.g. For example, a lack of randomization and blinding , too few samples , insufficient documentation, but also the difficulty of publishing results that do not confirm the original hypothesis stand in the way of a successful translation.

Functions and memberships

• 1993–1999: Director of the Laboratory for Experimental Neurology, Charité
• since 1999: Director of the Department of Experimental Neurology, Charité
• since 1999: Deputy Director Neuroscience Center, Charité
• since 2001: Joint head of the Department of Neurology at the Charité with Matthias Endres
• since 2001: Program Director of the International Master-MD and PhD Program Medical Neurosciences
• 2005 to 2007: Spokesman of the Collaborative Research Center SFB5007 “The importance of non-neuronal cells in neurological diseases” of the German Research Foundation
• since 2005: Member of the Commission for Helmholtz and Leibniz Scholarship Holders ( DAAD )
• 2006–2008: Member and member of the steering committee of the Berlin-Brandenburg Center for Regenerative Therapies (BCRT)
• 2006–2012: Member of the Approval Committee for the Graduate Schools of the German Research Foundation
• since 2007: Member, member of the board of directors and clinical coordinator of the NeuroCure Excellence Cluster
• 2007–2012: General Secretary of the Neuroscientific Society
• since 2008: Director of the Center for Stroke Research Berlin
• 2008–2013: Coordinator Affording Recovery in Stroke (ARISE), Coordinator of the European Stroke Network
• 2009–2016: Editor in Chief, Journal of Cerebral Blood Flow and Metabolism
• 2013–2017: Clinical coordinator of the German Center for Neurodegenerative Diseases
• 2013–2016: Member of the advisory board of the Wings for Life Foundation
• 2015: Co-founder and coordinator of SPARK-Berlin (together with Craig Garner)
• since 2017: Visiting Professor University of Oxford
• since 2017: Founding director of the QUEST (Quality | Ethics | Open Science | Translation) Center for Transforming Biomedical Research, Berlin Institute for Health Research
• since 2018: Elected member of the Academia Europaea

Scholarships and Awards

• 1993: Awarded the Gerhard Hess Prize of the German Research Foundation
• 1995–1999: Heisenberg grant from the German Research Foundation
• 2016: Presentation of the Thomas Willis Lecture Award, American Heart Association
• 2016: Award of the Berlin Science Prize
• 2017: Presentation of the Münster Heart Center Lecture Award, Stiftung Herzzentrum Universitätsklinikum Münster

Fonts (selection)

• ed. with Bernd Elger: Neuroinflammation in Stroke. Springer, Belin 2004, ISBN 3-540-40348-5 .
• (Ed.) Rodent Models of Stroke. Humana Press, Totowa 2010, ISBN 978-1-60761-749-5 ; 2nd edition: Human Press, New York 2016, ISBN 978-1-4939-5618-0 .
• with Jochen Müller: I think the blow hits me: Why the brain does what it should or sometimes not. Droemer, Munich 2016, ISBN 978-3-426-27679-2 .

Web links

• Ulrich Dirnagl's blog: dirnagl.com
• Interview in the online magazine of the Stifterverband Merton: We produce too much research waste
• Article in Die Zeit: Where did all the rodents go?
• Interview ZDF: Day against the stroke
• Interview Research Spirit Podcast: Trust and Control in Science
• Interview with Bayerischer Rundfunk from the series Nacht :sicht from February 13th, 2017, brain research

Individual evidence

1. ↑ David Speck: GNS | Secretary General. In: nwg.glia.mdc-berlin.de. Retrieved November 16, 2016 . 
2. ^ Hermann and Lilly Schilling Foundation for Medical Research . In: German Foundation Center . March 30, 2016 ( deutsches-stiftungszentrum.de [accessed November 16, 2016]).
3. ↑ CSB: CSB - AG Dirnagl. In: www.schlaganfallcentrum.de. Retrieved November 16, 2016 . 
4. ↑ CSB: CSB - quality improvement. In: www.schlaganfallcentrum.de. Retrieved November 16, 2016 . 
5. ↑ Malcolm R Macleod, Susan Michie, Ian Roberts, Ulrich Dirnagl, Iain Chalmers: Biomedical research: increasing value, reducing waste . In: The Lancet . tape 383 , no. 9912 , p. 101-104 , doi : 10.1016 / s0140-6736 (13) 62329-6 ( elsevier.com ).
6. ↑ Constance Holman, Sophie K. Piper, Ulrike Grittner, Andreas Antonios Diamantaras, Jonathan Kimmelman: Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke . In: PLOS Biology . tape 14 , no. 1 , January 4, 2016, ISSN  1545-7885 , p. e1002331 , doi : 10.1371 / journal.pbio.1002331 , PMID 26726833 , PMC 4699644 (free full text) - ( plos.org [accessed on November 16, 2016]).
7. ^ Ulrich Dirnagl: Bench to Bedside: The Quest for Quality in Experimental Stroke Research . In: Journal of Cerebral Blood Flow & Metabolism . tape 26 , no. 12 , December 1, 2006, ISSN  0271-678X , p. 1465-1478 , doi : 10.1038 / sj.jcbfm.9600298 , PMID 16525413 ( sagepub.com [accessed November 16, 2016]).
8. ↑ ^{a b c} Prof. Dr. Ulrich Dirnagl: CV Prof. Dr. Dirnagl . In: Website Experimental Neurology . ( charite.de [accessed on November 16, 2016]).
9. ↑ Lutz Steiner: Prof. Dr. Dirnagl . In: Name of the department . ( medical-neurosciences.de [accessed on November 17, 2016]).
10. ↑ CSB: CSB - AG Dirnagl. In: www.schlaganfallcentrum.de. Retrieved November 17, 2016 . 
11. ↑ Charité leads the EU-wide stroke network ARISE. In: idw-online.de. Retrieved November 18, 2016 . 
12. ↑ Journal of Cerebral Blood Flow & Metabolism | SAGE Publications Ltd. In: uk.sagepub.com. Retrieved November 17, 2016 . 
13. ↑ Prof. Dr. Ulrich Dirnagl: The bridge builder. In: www.wingsforlife.com. Retrieved November 17, 2016 . 
14. ^ Berlin Institute for Health Research - Charité and Max Delbrück Center: Contact. (No longer available online.) In: spark.bihealth.org. January 12, 2015, archived from the original on November 17, 2016 ; Retrieved November 17, 2016 . Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice.  
15. ^ University of Oxford: Oxford Gazette Notices. (No longer available online.) In: https://www.ox.ac.uk . February 9, 2017, archived from the original on February 11, 2017 ; accessed on February 9, 2017 (English). Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice.  
16. ^ Berlin Institute for Health Research - Charité and Max Delbrück Center: Transforming Biomedical Research. May 14, 2017. Retrieved May 14, 2017 . 
17. ^ Academy of Europe: Dirnagl Ulrich. Retrieved January 5, 2019 . 
18. ↑ American Stroke Association honors scientists - News on Heart.org . In: News on Heart.org . February 17, 2016 ( heart.org [accessed November 16, 2016]).
19. ↑ Müller presents the Governing Mayor's Science Prize 2016 to Ulrich Dirnagl. In: www.berlin.de. November 9, 2016, accessed November 16, 2016 . 
20. ↑ A heart from the Heart Foundation for Stroke Researchers. In: http://www.wn.de/Muenster . February 18, 2017, accessed March 8, 2017 .