Vasoactive substance

Vasoactive substances are substances that influence the vascular tone . They work through central or peripheral mechanisms.

• Vasodilators : vasodilator drugs that lower blood pressure , e.g. B. Alpha blockers , organic nitrates and nitroprusside
• Vasoconstrictors : vasoconstricting drugs that increase blood pressure, e.g. B. the ergot alkaloids and the administered as a nasal spray xylometazoline

Other vasoactive substances that are formed in the endothelium or activated on the endothelium are u. a. Prostacyclin , EDHF ( endothelium-derived hyperpolarizing factor , hyperpolarizing factor), acetylcholine , serotonin , histamine and bradykinin . In addition, vasoconstriction is influenced by systems such as the atrial natriuretic peptide (ANP), the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system .

literature

• Wolfgang Löscher, Fritz Rupert Ungemach , Reinhard Kroker (Hrsg.): Pharmacotherapy in domestic and farm animals . 7th completely revised and expanded edition. Paul Parey Verlag, Stuttgart 2006. ISBN 3-8304-4160-6 .

Individual evidence

1. ↑ Reinhard Larsen: Anesthesia and intensive medicine in cardiac, thoracic and vascular surgery. (1st edition 1986) 5th edition. Springer, Berlin / Heidelberg / New York et al. 1999, ISBN 3-540-65024-5 , pp. 65-70.