W. Clark Still

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W. Clark Still (born August 31, 1946 in Augusta , Georgia ) is an American chemist ( organic chemistry , computational chemistry ).

Still graduated from Emory University with a bachelor's degree in 1969 and a doctorate in organic chemistry in 1972. He was a post-doctoral student at Princeton University and Columbia University . In 1975 he became an Assistant Professor at Vanderbilt University and in 1977 at Columbia University, where he became an Associate Professor in 1980 and later Distinguished Professor .

In 1978 he developed the separation process of column chromatography . 1979 he succeeded with colleagues in the total synthesis of the sex pheromone of the American Cockroach , periplanone b . In 1980 he also undertook the total synthesis of the antibiotic monensin (which Yoshito Kishi succeeded a little earlier in 1979 ).

A variant of the 2,3-Wittig rearrangement is known as the Wittig-Still rearrangement (1978). He used it to synthesize the juvenile hormone of Hyalophora cecropia . With Cesare Gennari , he developed a variant of the Horner-Wadsworth-Emmons reaction (Still-Gennari olefination) in 1983 .

He later turned to computational chemistry, for example in the calculation of atomic and molecular surfaces that are accessible to the solvent, and Monte Carlo models for conformational analysis.

From 1993 he was on the supervisory board of Pharmaco-Poeias Inc. 1992 he was Rolf Sammet visiting professor in Frankfurt am Main and Sloan visiting professor at Harvard and 1986 Alexander Todd visiting professor in Cambridge.

In 1978 he received a research grant from the Alfred P. Sloan Foundation ( Sloan Research Fellowship ). He received the Alan T. Waterman Award in 1981 . In 1987 he was a Fellow of the Japan Society for the Promotion of Science. He is a Fellow of the American Academy of Arts and Sciences . From 1978 to 1980 he was a Sloan Research Fellow and 1981/82 Guggenheim Fellow . In 1993 he received the American Chemical Society's ACS Award for Computers in Chemical and Pharmaceutical Research . In 1984 he received the Stieglitz Award and in 1982 the Buchman Award from Caltech . In 1987 he received the ACS Cope Scholar Award.

Individual evidence

  1. Pamela Kalte u. a. (Eds.), American Men and Women of Science, Thomson Gale 2004
  2. ^ W. Clark Still, M Kahn, A. Mitra: Rapid Chromatographic Technique for Preparative Separations With Moderate Separation , J. Org. Chem., Volume 43, 1978, pp. 2923-2925
  3. Still's approach to the total synthesis of Monensin, pdf
  4. ^ K. Nicolaou, EJ Sorensen, Classics in Total Synthesis, VCH 1996
  5. ^ WC Still, DB Collum, JH McDonald: Synthesis of the Polyether Antibiotic Monensin. 3. Coupling of Precursors and Transformation to Monensin , J. Am. Chem. Soc., Vol. 102, 1980, pp. 2120-2121
  6. ^ WC Still, A. Mitra: A highly stereoselective synthesis of Z-trisubstituted olefins via [2,3] sigmatropic rearrangement. Preference for a pseudoaxially substituted transition state, J. Am. Chem. Soc., Vol. 100, 1978, pp. 1927-1928
  7. ^ WC Still, JH McDonald, D. Collum, A. Mitra: A Highly Stereoselective Synthesis of the C18 Cecropia Juvenile Hormone, Tetrahedron Lett., Volume 20, 1979, pp. 593-594
  8. ^ WC Still, C. Gennari, Direct synthesis of Z-unsaturated esters. A useful modification of the Horner-Emmons olefination, Tetrahedron Lett., Vol. 24, 1983, pp. 4405-4408