Werner Reutter

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Werner Reutter (born February 5, 1937 in Hornberg ; † May 28, 2016 ) was a German physician and molecular biologist. He was a professor at the Institute for Molecular Biology and Biochemistry at the Free University of Berlin .

Life

Werner Reutter studied human medicine and physics at the Universities of Freiburg and Munich from 1956 to 1962 . He received his doctorate from 1960 to 1962 at the Institute for Pharmacology at the University of Freiburg and passed the medical state examination in 1962. From 1962 to 1963 he was a medical assistant with Ludwig Heilmeyer at the Medical University Clinic Freiburg and in the Landshut District Hospital. In 1964 he received his doctorate and obtained his license to practice medicine. From 1964 to 1967 he worked as a research assistant at the Biochemical Institute of the University of Freiburg and from 1968 to 1972 he was a research assistant there . 1972 followed the habilitation and Venia legendi for the subject biochemistry and pathobiochemistry. From 1972 to 1977 he was senior assistant at the Biochemical Institute at the University of Freiburg. Then he was an adjunct professor there (AH 1).

In 1979 he became a full professor at the Institute for Molecular Biology and Biochemistry at the Free University of Berlin.

plant

His main research interests include glycomics , especially research on sialic acids . Together with D. Keppler, R. Lesch and K. Decker, he discovered galactosamine hepatitis . He carried out studies on the key enzyme in sialic acid biosynthesis and examined the processes of membrane-localized glycoproteins. He contributed to the development of new glycosidated phospholipids that inhibit cell growth and studied galactose as a dietary supplement to inhibit Alzheimer's disease and other forms of dementia .

Reutter worked on a study in which the processes of the metabolism of galactose were examined. The study showed how the cytotoxic ammonia is broken down when it is converted into amino acids, as occurs in the brain . Since ammonia is particularly problematic in Alzheimer's disease, this process helps detoxify the cell. Studies by the nutritionist Andreas Hahn also indicated a possible effect of galactose on cognitive disorders.

Further research by Reutter will examine the effects of galactose on people with dementia, especially Alzheimer's disease, in more detail.

He has received several awards, including a. 2012 with the Rosalind Kornfeld Award .

Publications (selection)

  • Martin Roser, Djuro Josic, Maria Kontou, Kurt Mosetter, Peter Maurer, Werner Reutter: Metabolism of galactose in the brain and liver of rats and its conversion into glutamate and other amino acids. J. Neural Transm. (2009) 116, pp. 131-139, doi: 10.1007 / s00702-008-0166-9 .
  • Maria Kontou, Christian Bauer, Werner Reutter, Rüdiger Horstkorte: Sialic acid metabolism is involved in the regulation of gene expression during neuronal differentiation of PC12 cells. Glycoconjugate Journal, Vol. 25, No. 3, pp. 237-244, doi: 10.1007 / s10719-008-9104-1 .
  • Werner Reutter, Rüdiger Horstkorte: Inhibition of Biosynthesis and Biochemical Modulation of N-Acylneuraminic Acid (Biochemical Engineering of Sialoconjugates). A review. In: Collection of Czechoslovak Chemical Communications , Volume 69, No. 10, pp. 1829–1842 ( abstract )
  • Oliver T. Keppler, Stephan Hinderlich, Josmar Langner, Reinhard Schwartz-Albiez, Werner Reutter, Michael Pawlita: UDP-GlcNAc 2-Epimerase: A Regulator of Cell Surface Sialylation. Science May 21, 1999, Volume 284, No. 5418, pp. 1372-1376, doi: 10.1126 / science.284.5418.1372 .
  • Michael Mickeleit, Thomas Wieder, Michael Arnold, Christoph C. Geilen, Johann Mulzer, Werner Reutter: A glucose-containing ether lipid (Glc-PAF) as an antiproliferative analogue to the platelet-activating factor. In: Angewandte Chemie. 110, 1998, p. 371, doi : 10.1002 / (SICI) 1521-3757 (19980202) 110: 3% 3C371 :: AID-ANGE371% 3E3.0.CO; 2-V .
  • W. Reutter, D. Keppler, R. Lesch, K. Decker: On the glycoprotein metabolism in galactosamine-induced hepatitis.
  • K. Decker, D. Keppler, W. Reutter: Galactosamine Hepatitis: Molecular Mechanism of an Experimental Disease. BIOspektrum 5, pp. 46-52 (1995)
  • PJ Grases, R. Lesch, U. Stein, H. Heissmeyer, W. Reutter: Aggravating and Protecting Effects of Triton and Prednisolone in Galactosamine Induced Hepatitis (PDF; 1.2 MB), Z. Klin. Chem. Klin. Biochem. Volume 10, 1972, pp. 539-542.
  • W. Reutter, R. Lesch, D. Keppler, K. Decker, Naturwiss. 55, p. 497 (1968)
  • D. Keppler, R. Lesch, W. Reutter, K. Decker, Exp. Molec. Pathol. 9, pp. 279-290 (1968)

Web links

Individual evidence

  1. ^ Katrin Hofmann: Kürschner's German Scholars Calendar, Volume 1, Issue 18, p. 2567, Saur, 2001
  2. ^ Obituary notice Wolfgang Reutter , FAZ , May 31, 2016
  3. ↑ a b c ( page no longer available , search in web archives: Werner Reutter ) at Impact of Glycomics@1@ 2Template: Dead Link / glycomics.libsyn.com
  4. ↑ a b Martin Roser, Djuro Josic, Maria Kontou, Kurt Mosetter, Peter Maurer, Werner Reutter: Metabolism of galactose in the brain and liver of rats and its conversion into glutamate and other amino acids. J. Neural Transm. (2009) 116, pp. 131-139, doi: 10.1007 / s00702-008-0166-9
  5. ↑ Andreas Hahn: ( Page no longer available , search in web archives: First results indicate possible effects of galactose on cognitive disorders. ) NewsArchiv, University of Hanover, December 10, 2008 (accessed on November 1, 2010)@1@ 2Template: Toter Link / www.nutrition.uni-hannover.de
  6. ↑ Diabetes in the head: New lead in the fight against dementia. A decisive impulse comes from a Charité researcher. (No longer available online.) Health +, archived from the original on December 5, 2011 ; Retrieved October 31, 2010 . Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. @1@ 2Template: Webachiv / IABot / www.healthplus.de
  7. ^ Galactose Project. (No longer available online.) Pandora Foundation, formerly the original ; Retrieved October 31, 2010 .  ( Page no longer available , search in web archives )@1@ 2Template: Dead Link / www.pandora-stiftung.eu
  8. ↑ Werner Reutter wins 2012 Rosalind Kornfeld Award ( Memento of the original from May 31, 2016 in the Internet Archive ) Info: The @1@ 2Template: Webachiv / IABot / www.glycobiology.org archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. at www.glycobiology.org , accessed May 31, 2016 (English)
personal data
SURNAME Reutter, Werner
BRIEF DESCRIPTION German physician and molecular biologist
DATE OF BIRTH February 5, 1937
PLACE OF BIRTH Hornberg
DATE OF DEATH May 28, 2016