Wolfgang Koenig (cardiologist)

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Wolfgang Koenig

Wolfgang Koenig (born December 18, 1949 in Neuenbürg ) is a German internist , cardiologist and university professor. Until 2015 he worked as senior physician in the Department of Internal Medicine II - Cardiology, Angiology , Pneumology , Sports and Rehabilitation Medicine at the Medical Clinic of the University of Ulm and is responsible for his work in the field of evaluating new biomarkers for cardiometabolic diseases including population-related genomics and known about the relationship between inflammation , hemostasis and atherosclerosis .

Life

Koenig studied medicine at the LMU Munich from 1969 to 1975 . In 1976 he passed the American state examination ( ECFMG ) , also in Munich . From 1976–1977 he worked as a medical assistant at the Munich-Schwabing Municipal Hospital , then worked as an assistant doctor at the Höhenried Clinic for Cardiovascular Diseases at the LVA Oberbayern in Bernried until 1980, before earning his doctorate in 1980 at the University of Heidelberg . Until 1983 he worked as a scientific assistant at various institutes and from 1983 to 1986 he was head of the MONICA heart attack register of the World Health Organization (WHO) at the Augsburg Central Hospital . In 1986 Koenig moved to the Medical Clinic at Ulm University. There he became a doctor for internal medicine in 1989 and has been doing the additional qualification in cardiology since 1992. In the same year he completed his habilitation with a thesis on the flow properties of blood with the title Blood rheology : connections with cardiovascular risk factors and coronary heart disease . In 1998 he was appointed adjunct professor and in 2005 obtained the additional title of internal intensive care medicine . From 1995–2000 Koenig was the managing senior physician of the medical clinic and head of the emergency department, 2003–04 head of the intensive care unit and 2004–05 head of the cardiac catheter laboratories. Until the end of March 2015, Koenig was senior physician in the Department of Internal Medicine II - Cardiology at the Medical University Clinic Ulm and headed the biomarker laboratory there and the “Clinical Study Center”. On April 1, 2015, he moved to the German Heart Center Munich at the Technical University of Munich , where he is primarily involved in research.

Scientific contribution

Koenig carried out many years of research in the field of clinical epidemiology of cardiovascular diseases (including setting up the MONICA Augsburg infarct register of the WHO. He made fundamental contributions to the inflammation hypothesis of atherosclerosis and the importance of hemostaseological factors for atherogenesis. As well as to the genetics of intermediate phenotypes of atherosclerosis.

He is a member of the governing body of numerous international clinical studies on innovative cardiometabolically active substances.

Research projects subsidized with third-party funds

Koenig acquired extensive third-party funding for science projects:

  • European Union Contract QLK4-CT-2002-02236. AIRGENE: Air pollution and inflammatory response in myocardial infarction survivors: Gene-environment-interaction in a high risk group. Core laboratory for biomarkers. (03/2004 - 03/2007)
  • European Collaborative Project on Inflammation and Vascular Wall Remodelling in Atherosclerosis (AtheroRemo) (HEALTH-2007-2.4.2-1) (06/2008 - 12/2013)
  • Cardiovascular network in the NGFN. Inflammation and immune response in the pathogenes of type 2 diabetes and atherosclerosis: testing the common soul hypothesis (06/2004 - 05/2008)
  • NGFN-Plus Consortium AtheroGenomics (06/2008 - 06/2014). Member of the CHARGE Consortium on GWAS of markers of inflammation and hemostasis.
  • European Collaborative Project on Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE): HEALTH.2011.2.4.2-2: Evaluation and validation studies of clinically useful biomarkers in prevention and management of cardiovascular diseases. Project no.278913 (Leader WP 7) (10/2011 - to date). Member of the Steering Committee.

Together with B. Thorand, H. Kolb, S. Martin and C. Herder: DFG proposals: Are inflammatory processes and endothelial dysfunction a common cause of type 2 diabetes and myocardial infarction ?

Membership in national and international scientific associations

  • Member of the New York Academy of Sciences (1981, elected)
  • Member of the American College of Epidemiology (1988, elected)
  • Member of the German Cardiac Society / Dt. Ges. For cardiology / cardiovascular research
  • Member of the American Heart Association
  • Member of the American Society of Hypertension
  • Member of the Royal Society of Medicine (Edinburgh) (1993, elected)
  • Fellow of the European Society of Cardiology, FESC (1997, elected)
  • Fellow of the American College of Cardiology, FACC (1998, elected)
  • Speaker of the Clinical Epidemiology Working Group of the German Cardiac Society (1999–2002)
  • Clinical Hypertension Specialist of the European Society of Hypertension (2002, elected)
  • Hypertensiologist DHL (2004, elected)
  • Fellow of the Royal College of Physicians (Edinburgh), FRCP (2005, elected)
  • Fellow of the American Heart Association, FAHA (2006, elected)

Expert activities

Koenig works as a reviewer for numerous medical journals as well as national and international research institutions. He is a member of the Editorial Board of Clinical Chemistry and Atherosclerosis, and was Associate Editor of Atherosclerosis from 2007 to 2014.

honors and awards

  • 2014 Awarded the Rudolf Schönheimer Medal of the German Society for Atherosclerosis Research
  • 2015 Honorary Award, Lecture on Epidemiology of the German Society for Cardiology

Publications

Koenig is the author and co-author of more than 600 publications and more than 500 lectures / posters in the fields of clinical cardiology, cardiovascular pharmacology, clinical epidemiology , cardiovascular epidemiology , hypertension, and cardiovascular disease genetics

List of publications on ResearchGate

List of publications on PubMed (not complete)

Web links

Individual evidence

  1. ^ W. Koenig, M. Sund, GD. Lowe, AJ. Lee, KL. Resch, Tunstall-H. Pedoe, U. Keil, E. Ernst: Geographical variations in plasma viscosity and relation to coronary event rates . In: Lancet , 1994 Sep 10; 344 (8924), pp. 711-714
  2. ↑ A. Peters, A. Döring, HE. Wichmann, W. Koenig: Increased plasma viscosity during an air pollution episode: a link to mortality? In: Lancet , 1997 May 31; 349 (9065), pp. 1582-1587.
  3. ↑ B. Staels, W. Koenig, A. Habib, R. Merval, M. Lebret, IP. Torra, P. Delerive, A. Fadel, G. Chinetti, JC. Fruchart, J. Najib, J. Maclouf, A. Tedgui: Activation of human aortic smooth-muscle cells is inhibited by PPARalpha but not by PPARgamma activators . In: Nature , 1998 Jun 25; 393 (6687), pp. 790-793.
  4. ↑ W. Koenig, M. Sund, M. Fröhlich, HG. Fischer, H. Löwel, A. Döring, WL. Hutchinson, MB. Pepys: C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992 . In: Circulation , 1999 Jan 19; 99 (2), pp. 237-242.
  5. ↑ A. Imhof, M. Froehlich, H. Brenner, H. Boeing, MB. Pepys, W. Koenig: Effect of alcohol consumption on systemic markers of inflammation . In: Lancet , 2001 Mar 10; 357 (9258), pp. 763-767.
  6. ^ W. Koenig, H. Löwel, J. Baumert, C. Meisinger: C-reactive protein modulates risk prediction based on the Framingham Score: implications for future risk assessment: results from a large cohort study in southern Germany . In: Circulation , 2004 Mar 23; 109 (11), pp. 1349-1353. Epub 2004 Mar 15.
  7. ^ C. Meisinger, J. Baumert, N. Khuseyinova, H. Loewel, W. Koenig: Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population . In: Circulation , 2005 Aug 2; 112 (5), pp. 651-657. Epub 2005 Jul 25.
  8. ↑ W. Koenig, N. Khuseyinova, J. Baumert, C. Meisinger, H. Lowel: Serum Concentrations of adiponectin and risk of type 2 diabetes mellitus and coronary heart disease in apparently healthy middle-aged men: results from the 18-year Follow-up of a large cohort from southern Germany . In: J Am Coll Cardiol , 2006 Oct 3; 48 (7), pp. 1369-1377.
  9. ↑ A. Spahr, E. Klein, N. Khuseyinova, C. Boeckh, G. Pezeshki, R. Muche, M. Kunze, D. Rothenbacher, A. Hoffmeister, W. Koenig: Periodontal infections and coronary heart disease: Role of periodontal bacteria and importance of total pathogen burden . The Coronary Event and Periodontal Disease (CORODONT) Study. Arch Intern Med. 2006 Mar 13; 166 (5), pp. 554-559.
  10. ↑ PM. Ridker, E. Danielson, FA. Fonseca, J. Genest, AM. Gotto Jr, JJ. Kastelein, W. Koenig, P. Libby, AJ. Lorenzatti, JG. MacFadyen, BG. Nordestgaard, J. Shepherd, JT. Willerson, RJ. Glynn: Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. JUPITER Study Group . In: N Engl J Med , 2008 Nov 20; 359 (21), pp. 2195-2207. doi: 10.1056 / NEJMoa0807646 . Epub 2008 Nov 9.
  11. Jump up ↑ J. Robert Glynn, Eleanor Danielson, Francisco AH Fonseca, Jacques Genest, Antonio M. Gotto Jr., John JP Kastelein, Wolfgang Koenig, Peter Libby , Alberto J. Lorenzatti, Jean G. MacFadyen, BA, Børge G. Nordestgaard, James Shepherd, James T. Willerson, Paul M Ridker: A Randomized Trial of Rosuvastatin in the Prevention of Venous Thromboembolism . N Engl J Med 2009; 360, pp. 1851–1861, doi: 10.1056 / NEJMoa0900241
  12. ^ W. Koenig, CY. Vossen, Z. Mallat, H. Brenner, J. Benessiano, D. Rothenbacher: Association between type II secretory phospholipase A2 plasma concentrations and activity and cardiovascular events in patients with coronary heart disease . In: Eur Heart J , 2009 Nov; 30 (22), pp. 2742-2748. doi: 10.1093 / eurheartj / ehp302 . Epub 2009 Aug 7.
  13. ^ N. Sarwar et al .: Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Emerging Risk Factors Collaboration . In: Lancet , 2010 Jun 26; 375 (9733), pp. 2215-2222. doi: 10.1016 / S0140-6736 (10) 60484-9 .
  14. ↑ A. Thompson, P. Gao, L. Orfei), S. Watson, E Di Angelantonio, S. Kaptoge, C. Ballantyne, CP. Cannon, M. Criqui, M. Cushman, A. Hofman, C. Packard, SG. Thompson, R. Collins, J. Danesh: Lipoprotein-associated phospholipase A (2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies. Lp-PLA (2) Studies Collaboration . In: Lancet , 2010 May 1; 375 (9725), pp. 1536-1544. doi: 10.1016 / S0140-6736 (10) 60319-4 .
  15. ^ J. Danesh et al .: Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. Fibrinogen Studies Collaboration . In: JAMA , 2005 Oct 12; 294 (14), pp. 1799-1809.
  16. ↑ NL. Smith et al .: Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium . In: Circulation , 2010 Mar 30; 121 (12), pp. 1382-1392. doi: 10.1161 / CIRCULATIONAHA.109.869156 . Epub 2010 Mar 15.
  17. ↑ A. Dehghan et al .: Meta-analysis of genome-wide association studies in> 80,000 subjects identifies multiple loci for C-reactive protein levels . In: Circulation , 2011 Feb 22; 123 (7), pp. 731-738. doi: 10.1161 / CIRCULATIONAHA.110.948570 . Epub 2011 Feb 7.
  18. ↑ NL. Smith et al .: Genetic predictors of fibrin D-dimer levels in healthy adults . In: Circulation , 2011 May 3; 123 (17), pp. 1864–1872. doi: 10.1161 / CIRCULATIONAHA.110.009480 . Epub 2011 Apr 18.
  19. ^ N. Sarwar et al .: Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. IL6R Genetics Consortium Emerging Risk Factors Collaboration . In: Lancet , 2012 Mar 31; 379 (9822), pp. 1205-1213. doi: 10.1016 / S0140-6736 (11) 61931-4 . Epub 2012 Mar 14.
  20. ^ N. Franceschini et al .: Discovery and fine mapping of serum protein loci through transethnic meta-analysis . In: Am J Hum Genet , 2012 Oct 5; 91 (4), pp. 744-753. doi: 10.1016 / j.ajhg.2012.08.021 . Epub 2012 Sep 27.
  21. ↑ P. Deloukas et al .: Large-scale association analysis identifies new risk loci for coronary artery disease. DIAGRAM Consortium; CARDIOGENICS Consortium . In: Nat Genet , 2013 Jan; 45 (1), pp. 25–33. doi: 10.1038 / ng.2480 . Epub 2012 Dec 2.
  22. ↑ AS. Doney et al .: CARDIoGRAMplusC4D Consortium . In: Nat Genet , 2013 Jan; 45 (1), pp. 25–33. doi: 10.1038 / ng.2480 . Epub 2012 Dec 2.
  23. ↑ P. Deloukas et al .: Large-scale association analysis identifies new risk loci for coronary artery disease. CARDIoGRAMplusC4D Consortium . In: Nat Genet , 2013 Jan; 45 (1), pp. 25–33. doi: 10.1038 / ng.2480 . Epub 2012 Dec 2.
  24. ↑ SI. Berndt et al .: Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture . In: Nat Genet , 2013 May; 45 (5), pp. 501-512. doi: 10.1038 / ng.2606 . Epub 2013 Apr 7.
  25. ↑ M Sabater-Lleal et al .: VTE Consortium; STROKE Consortium; Wellcome Trust Case Control Consortium 2 (WTCCC2); C4D Consortium; CARDIoGRAM Consortium
  26. ^ H. Wallaschofski, NL. Smith, D. Tregouet, PM. Ridker, W. Tang, DP. Strachan, A. Hamsten, CJ. O'Donnell: Multiethnic meta-analysis of genome-wide association studies in> 100,000 subjects identifies 23 fibrinogen-associated loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease . In: Circulation , 2013 Sep 17; 128 (12), pp. 1310-1324. doi: 10.1161 / CIRCULATIONAHA.113.002251 . Epub 2013 Aug 22.
  27. ↑ MV. Holmes et al .: Secretory phospholipase A (2) -IIA and cardiovascular disease: a mendelian randomization study . In: J Am Coll Cardiol , 2013 Nov 19; 62 (21), pp. 1966-1976. doi: 10.1016 / j.jacc.2013.06.044 . Epub 2013 Jul 31.
  28. ↑ D. Shungin et al .: New genetic loci link adipose and insulin biology to body fat distribution . In: Nature , 2015 Feb 12; 518 (7538), pp. 187-196. doi: 10.1038 / nature14132 .
  29. ↑ AE. Locke et al .: Genetic studies of body mass index yield new insights for obesity biology . In: Nature , 2015 Feb 12; 518 (7538), pp. 197-206. doi: 10.1038 / nature14177 .
  30. ↑ JC. Tardif, CM. Ballantyne, P. Barter, JL. Dasseux, ZA. Fayad, MC. Guertin, JJ. Kastelein, C. Keyserling, H. Klepp, W. Koenig, PL L'Allier, Lespérance J, TF. Lüscher, JF. Paolini, A. Tawakol, DD. Waters: Effects of the high-density lipoprotein mimetic agent CER-001 on coronary atherosclerosis in patients with acute coronary syndromes: a randomized trial.Can HDL Infusions Significantly QUicken Atherosclerosis REgression (CHI-SQUARE) Investigators . In: Eur Heart J , 2014 Dec 7; 35 (46), pp. 3277-3286. doi: 10.1093 / eurheartj / ehu171 . Epub 2014 Apr 29.
  31. ↑ SJ. Nicholls, JJ. Kastelein, GG. Schwartz, D. Bash, RS. Rosenson, MA. Cavender, DM. Brennan, W. Koenig, JW. Jukema, V. Nambi, RS. Wright, V. Menon, AM. Lincoff, SE. Nissen: VISTA-16 Investigators. Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial . In: JAMA , 2014 Jan 15; 311 (3), pp. 252–262. doi: 10.1001 / jama.2013.282836 .
  32. Jump up ↑ J. Robert Glynn, Eleanor Danielson, Francisco AH Fonseca, Jacques Genest, Antonio M. Gotto Jr., John JP Kastelein, Wolfgang Koenig, Peter Libby , Alberto J. Lorenzatti, Jean G. MacFadyen, BA, Børge G. Nordestgaard, James Shepherd, James T. Willerson, Paul M Ridker: A Randomized Trial of Rosuvastatin in the Prevention of Venous Thromboembolism . N Engl J Med, 2009, 360, pp. 1851-1861, doi: 10.1056 / NEJMoa0900241
  33. ↑ R. Ladeiras-Lopes, S. Agewall, A. Tawakol, B. Staels, E. Stein, RJ. Mentz, A. Leite-Moreira, F. Zannad, W. Koenig: Atherosclerosis: Recent trials, new targets and future directions . In: Int J Cardiol , 2015 Aug 1; 192, pp. 72-81. doi: 10.1016 / j.ijcard.2015.05.013 . Epub 2015 May 8th Review. PMID 26002254
  34. ↑ DFG proposals Th784 / 2-1 and TH 784 / 2-2 from 2001 to 2011
  35. ↑ Hypertensiologist
  36. ^ Rudolf Schönheimer Medal
  37. ↑ German Society for Atherosclerosis Research
personal data
SURNAME Koenig, Wolfgang
BRIEF DESCRIPTION German cardiology
DATE OF BIRTH December 18, 1949
PLACE OF BIRTH Neuenbürg