Zileuton

Structural formula
	1: 1 mixture of ( R ) -form (top) and ( S ) -form (bottom)
General
Non-proprietary name	Zileuton
other names	( RS ) -1- (1-Benzothiophen-2-ylethyl) -1-hydroxyurea; (±) -1- (1-Benzothiophen-2-ylethyl) -1-hydroxyurea;
Molecular formula	C 11 H 12 N 2 O 2 S
External identifiers / databases
EC number	601-087-3
ECHA InfoCard	100.121.111
PubChem	60490
DrugBank	DB00744
Wikidata	Q202998
Drug information
Drug class	Lipoxygenase inhibitor
properties
Molar mass	236.29 g · mol -1
Physical state	firmly
Melting point	157-158 ° C
safety instructions
GHS labeling of hazardous substances Caution
H and P phrases	H: 302-319
	P: ?
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

Zileuton is a 5-lipoxygenase inhibitor . It acts selectively and reversibly on 5-lipoxygenase , which produces leukotrienes LTA ₄ , LTB ₄ , LTC ₄ , LTD ₄ and LTE ₄ released in the event of inflammation .

Zileuton is used in the USA as a medicinal substance for mild to moderate bronchial asthma . An effect is also expected against other inflammatory diseases, but this is still to be proven by studies.

In Germany there are no approved finished medicinal products with this active ingredient.

Individual evidence

^ The Merck Index : An Encyclopedia of Chemicals, Drugs, and Biologicals , 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006; P. 1746, ISBN 978-0-911910-00-1 .
↑ Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . A labeling of (RS) -N- [1- (1-benzothien-2-yl) ethyl] -N-hydroxyurea in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), retrieved on December 12, is reproduced from a self-classification by the distributor July 2020.
↑ ABDA database (as of June 18, 2008) of DIMDI .

Web links

[MERCK_Index-1] The Merck Index : An Encyclopedia of Chemicals, Drugs, and Biologicals , 14th Edition (Merck & Co., Inc.), Whitehouse Station, NJ, USA, 2006; P. 1746, ISBN 978-0-911910-00-1 .

[2] Template: CL Inventory / not harmonized There is not yet a harmonized classification for this substance . A labeling of (RS) -N- [1- (1-benzothien-2-yl) ethyl] -N-hydroxyurea in the Classification and Labeling Inventory of the European Chemicals Agency (ECHA), retrieved on December 12, is reproduced from a self-classification by the distributor July 2020.

[DIMDI-3] ABDA database (as of June 18, 2008) of DIMDI .