SLC27A3: Difference between revisions

SLC27A3
Identifiers
Aliases	SLC27A3, ACSVL3, FATP3, VLCS-3, solute carrier family 27 member 3
External IDs	OMIM: 604193; MGI: 1347358; HomoloGene: 11529; GeneCards: SLC27A3; OMA:SLC27A3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	153,780,157 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	90,297,245 bp
RNA expression pattern
	Top expressed in
	ascending aorta; ; right lung; ; gastric mucosa; ; right coronary artery; ; subcutaneous adipose tissue; ; upper lobe of left lung; ; left coronary artery; ; monocyte; ; right uterine tube; ; right lobe of liver;
	Top expressed in
	yolk sac; ; adrenal gland; ; lip; ; renal corpuscle; ; urethra; ; spermatocyte; ; saccule; ; neural tube; ; otic placode; ; calvaria;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	long-chain fatty acid-CoA ligase activity; nucleotide binding; ligase activity; catalytic activity; very long-chain fatty acid-CoA ligase activity; long-chain fatty acid transporter activity; ATP binding;
Cellular component	integral component of membrane; membrane; mitochondrial membranes; mitochondrion; endoplasmic reticulum;
Biological process	metabolism; long-chain fatty acid metabolic process; fatty acid metabolic process; lipid metabolism; long-chain fatty acid transport;
	Sources:Amigo / QuickGO
Orthologs
	11000
	26568
	ENSG00000263163; ENSG00000143554
	ENSMUSG00000027932
	Q5K4L6
	O88561
	NM_024330; NM_001317929
	NM_011988; NM_001316688
	NP_001304858; NP_077306
	NP_001303617; NP_036118
	Wikidata
View/Edit Human	View/Edit Mouse

Browse history interactively

Content deleted Content added

VisualWikitext

Inline

Latest revision as of 20:51, 3 March 2023

Long-chain fatty acid transport protein 3 is a protein that in humans is encoded by the SLC27A3 gene.^[5]^[6]

In melanocytic cells SLC27A3 gene expression may be regulated by MITF.^[7]

References[edit]

^ ^a ^b ^c ENSG00000143554 GRCh38: Ensembl release 89: ENSG00000263163, ENSG00000143554 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027932 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hirsch D, Stahl A, Lodish HF (Aug 1998). "A family of fatty acid transporters conserved from mycobacterium to man". Proc Natl Acad Sci U S A. 95 (15): 8625–9. Bibcode:1998PNAS...95.8625H. doi:10.1073/pnas.95.15.8625. PMC 21126. PMID 9671728.
^ "Entrez Gene: SLC27A3 solute carrier family 27 (fatty acid transporter), member 3".
^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading[edit]

Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Pei Z, Fraisl P, Berger J, et al. (2005). "Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells". J. Biol. Chem. 279 (52): 54454–62. doi:10.1074/jbc.M410091200. PMID 15469937.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000143554 GRCh38: Ensembl release 89: ENSG00000263163, ENSG00000143554 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027932 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9671728-5] Hirsch D, Stahl A, Lodish HF (Aug 1998). "A family of fatty acid transporters conserved from mycobacterium to man". Proc Natl Acad Sci U S A. 95 (15): 8625–9. Bibcode:1998PNAS...95.8625H. doi:10.1073/pnas.95.15.8625. PMC 21126. PMID 9671728.

[entrez-6] "Entrez Gene: SLC27A3 solute carrier family 27 (fatty acid transporter), member 3".

[pmid19067971-7] Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Long-chain fatty acid transport protein 3''' is a [[protein]] that in humans is encoded by the ''SLC27A3'' [[gene]].<ref name="pmid9671728">{{cite journal | vauthors = Hirsch D, Stahl A, Lodish HF | title = A family of fatty acid transporters conserved from mycobacterium to man | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 15 | pages = 8625–9 |date=Aug 1998 | pmid = 9671728 | pmc = 21126 | doi =10.1073/pnas.95.15.8625  | bibcode = 1998PNAS...95.8625H | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC27A3 solute carrier family 27 (fatty acid transporter), member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11000}}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
+In melanocytic cells SLC27A3 gene expression may be regulated by [[Microphthalmia-associated transcription factor|MITF]].<ref name="pmid19067971">{{cite journal  |vauthors=Hoek KS, Schlegel NC, Eichhoff OM, etal | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x | doi-access = free }}</ref>
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 27 (fatty acid transporter), member 3
- | HGNCid = 10997
- | Symbol = SLC27A3
- | AltSymbols =; ACSVL3; FATP3; MGC4365; VLCS-3
- | OMIM = 604193
- | ECnumber =
- | Homologene = 11529
- | MGIid = 1347358
- | GeneAtlas_image1 = PBB_GE_SLC27A3_222217_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}}{{GNF_GO|id=GO:0004321 |text = fatty-acyl-CoA synthase activity}}{{GNF_GO|id=GO:0016874 |text = ligase activity}}
- | Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006631 |text = fatty acid metabolic process}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 11000
-    | Hs_Ensembl = ENSG00000143554
-    | Hs_RefseqProtein = NP_077306
-    | Hs_RefseqmRNA = NM_024330
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 1
-    | Hs_GenLoc_start = 152013454
-    | Hs_GenLoc_end = 152019257
-    | Hs_Uniprot = Q5K4L6
-    | Mm_EntrezGene = 26568
-    | Mm_Ensembl = ENSMUSG00000027932
-    | Mm_RefseqmRNA = NM_011988
-    | Mm_RefseqProtein = NP_036118
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 3
-    | Mm_GenLoc_start = 90471167
-    | Mm_GenLoc_end = 90475865
-    | Mm_Uniprot = Q2UZQ7
-  }}
-}}
-'''Solute carrier family 27 (fatty acid transporter), member 3''', also known as '''SLC27A3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC27A3 solute carrier family 27 (fatty acid transporter), member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11000| accessdate = }}</ref>
+==See also==
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+* {{MeshName|SLC27A3+protein,+human}}
-{{PBB_Summary
+* [[Solute carrier family]]
-| section_title =
-| summary_text =
-}}
 ==References==
 {{reflist}}
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |doi-access= free }}
-{{PBB_Further_reading
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-| citations =
-*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
+*{{cite journal   |vauthors=Pei Z, Fraisl P, Berger J, etal |title=Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells |journal=J. Biol. Chem. |volume=279 |issue= 52 |pages= 54454–62 |year= 2005 |pmid= 15469937 |doi= 10.1074/jbc.M410091200 |doi-access= free }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
-*{{cite journal  | author=Pei Z, Fraisl P, Berger J, ''et al.'' |title=Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells. |journal=J. Biol. Chem. |volume=279 |issue= 52 |pages= 54454-62 |year= 2005 |pmid= 15469937 |doi= 10.1074/jbc.M410091200 }}
+*{{cite journal   |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Hirsch D, Stahl A, Lodish HF |title=A family of fatty acid transporters conserved from mycobacterium to man. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 15 |pages= 8625-9 |year= 1998 |pmid= 9671728 |doi=  }}
-}}
 {{refend}}
-{{protein-stub}}
+{{NLM content}}
+{{Membrane transport proteins}}
+[[Category:Solute carrier family]]
+{{membrane-protein-stub}}

Latest revision as of 20:51, 3 March 2023

See also[edit]

References[edit]

Further reading[edit]