SLC20A1: Difference between revisions

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Importing Wikidata short description: Protein-coding gene in the species Homo sapiens (shortdescs-in-category)
 
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{PBB|geneid=6574}}
{{Infobox_gene}}
'''Sodium-dependent phosphate transporter 1''' is a [[protein]] that in humans is encoded by the ''SLC20A1'' [[gene]].<ref name="pmid8041748">{{cite journal | author = Kavanaugh MP, Miller DG, Zhang W, Law W, Kozak SL, Kabat D, Miller AD | title = Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 15 | pages = 7071–5 | year = 1994 | month = Aug | pmid = 8041748 | pmc = 44340 | doi =10.1073/pnas.91.15.7071 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC20A1 solute carrier family 20 (phosphate transporter), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6574| accessdate = }}</ref>
'''Sodium-dependent phosphate transporter 1''' is a [[protein]] that in humans is encoded by the ''SLC20A1'' [[gene]].<ref name="pmid8041748">{{cite journal | vauthors = Kavanaugh MP, Miller DG, Zhang W, Law W, Kozak SL, Kabat D, Miller AD | title = Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters | journal = Proc Natl Acad Sci U S A | volume = 91 | issue = 15 | pages = 7071–5 |date=Aug 1994 | pmid = 8041748 | pmc = 44340 | doi =10.1073/pnas.91.15.7071 | bibcode = 1994PNAS...91.7071K | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC20A1 solute carrier family 20 (phosphate transporter), member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6574}}</ref>


Retrovirus receptors allow infection of human and murine cells by various [[retrovirus]]es. The receptors that have been identified at the molecular level include [[CD4]] (MIM 186940) for [[human immunodeficiency virus]], Rec1 for murine ecotropic virus, and GLVR1 for [[gibbon ape leukemia virus]] (see MIM 182090). These 3 proteins show no homology to one another at the DNA or protein level. GLVR1 is a [[sodium-dependent phosphate symporter]].[supplied by OMIM]<ref name="entrez" />
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->

{{PBB_Summary
==Research==
| section_title =

| summary_text = Retrovirus receptors allow infection of human and murine cells by various retroviruses. The receptors that have been identified at the molecular level include CD4 (MIM 186940) for human immunodeficiency virus, Rec1 for murine ecotropic virus, and GLVR1 for gibbon ape leukemia virus (see MIM 182090). These 3 proteins show no homology to one another at the DNA or protein level. GLVR1 is a sodium-dependent phosphate symporter.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SLC20A1 solute carrier family 20 (phosphate transporter), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6574| accessdate = }}</ref>
It was reported that mutations of the gene may cause [[epispadias]] or [[bladder exstrophy]].<ref name="RiekeZhang2020">{{cite journal | vauthors = Rieke JM, Zhang R, Braun D, Yilmaz Ö, Japp AS, Lopes FM, etal |title=SLC20A1 Is Involved in Urinary Tract and Urorectal Development|journal=Frontiers in Cell and Developmental Biology|volume=8|year=2020 |page=567|doi=10.3389/fcell.2020.00567|pmid=32850778|pmc=7426641|doi-access=free}}</ref>
}}


==See also==
==See also==
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==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal |vauthors=Takeuchi Y, Vile RG, Simpson G, etal |title=Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus. |journal=J. Virol. |volume=66 |issue= 2 |pages= 1219–22 |year= 1992 |pmid= 1309898 |doi= 10.1128/JVI.66.2.1219-1222.1992| pmc=240831 }}
{{PBB_Further_reading
*{{cite journal | vauthors=Johann SV, Gibbons JJ, O'Hara B |title=GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus. |journal=J. Virol. |volume=66 |issue= 3 |pages= 1635–40 |year= 1992 |pmid= 1531369 |doi= 10.1128/JVI.66.3.1635-1640.1992| pmc=240899 }}
| citations =
*{{cite journal | author=Takeuchi Y, Vile RG, Simpson G, ''et al.'' |title=Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus. |journal=J. Virol. |volume=66 |issue= 2 |pages= 1219–22 |year= 1992 |pmid= 1309898 |doi= | pmc=240831 }}
*{{cite journal |vauthors=Kaelbling M, Eddy R, Shows TB, etal |title=Localization of the human gene allowing infection by gibbon ape leukemia virus to human chromosome region 2q11-q14 and to the homologous region on mouse chromosome 2. |journal=J. Virol. |volume=65 |issue= 4 |pages= 1743–7 |year= 1991 |pmid= 1672162 |doi= 10.1128/JVI.65.4.1743-1747.1991| pmc=239979 }}
*{{cite journal | author=Johann SV, Gibbons JJ, O'Hara B |title=GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus. |journal=J. Virol. |volume=66 |issue= 3 |pages= 1635–40 |year= 1992 |pmid= 1531369 |doi= | pmc=240899 }}
*{{cite journal |vauthors=O'Hara B, Johann SV, Klinger HP, etal |title=Characterization of a human gene conferring sensitivity to infection by gibbon ape leukemia virus. |journal=Cell Growth Differ. |volume=1 |issue= 3 |pages= 119–27 |year= 1991 |pmid= 2078500 }}
*{{cite journal | author=Kaelbling M, Eddy R, Shows TB, ''et al.'' |title=Localization of the human gene allowing infection by gibbon ape leukemia virus to human chromosome region 2q11-q14 and to the homologous region on mouse chromosome 2. |journal=J. Virol. |volume=65 |issue= 4 |pages= 1743–7 |year= 1991 |pmid= 1672162 |doi= | pmc=239979 }}
*{{cite journal |vauthors=Olah Z, Lehel C, Anderson WB, etal |title=The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter. |journal=J. Biol. Chem. |volume=269 |issue= 41 |pages= 25426–31 |year= 1994 |doi=10.1016/S0021-9258(18)47267-5 |pmid= 7929240 |doi-access=free }}
*{{cite journal | author=O'Hara B, Johann SV, Klinger HP, ''et al.'' |title=Characterization of a human gene conferring sensitivity to infection by gibbon ape leukemia virus. |journal=Cell Growth Differ. |volume=1 |issue= 3 |pages= 119–27 |year= 1991 |pmid= 2078500 |doi= }}
*{{cite journal | vauthors=Miller DG, Miller AD |title=A family of retroviruses that utilize related phosphate transporters for cell entry. |journal=J. Virol. |volume=68 |issue= 12 |pages= 8270–6 |year= 1994 |pmid= 7966619 |doi= 10.1128/JVI.68.12.8270-8276.1994| pmc=237294 }}
*{{cite journal | author=Olah Z, Lehel C, Anderson WB, ''et al.'' |title=The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter. |journal=J. Biol. Chem. |volume=269 |issue= 41 |pages= 25426–31 |year= 1994 |pmid= 7929240 |doi= }}
*{{cite journal | vauthors=Johann SV, van Zeijl M, Cekleniak J, O'Hara B |title=Definition of a domain of GLVR1 which is necessary for infection by gibbon ape leukemia virus and which is highly polymorphic between species. |journal=J. Virol. |volume=67 |issue= 11 |pages= 6733–6 |year= 1993 |pmid= 8411375 |doi= 10.1128/JVI.67.11.6733-6736.1993| pmc=238113 }}
*{{cite journal | author=Miller DG, Miller AD |title=A family of retroviruses that utilize related phosphate transporters for cell entry. |journal=J. Virol. |volume=68 |issue= 12 |pages= 8270–6 |year= 1994 |pmid= 7966619 |doi= | pmc=237294 }}
*{{cite journal |vauthors=Tatsumi S, Segawa H, Morita K, etal |title=Molecular cloning and hormonal regulation of PiT-1, a sodium-dependent phosphate cotransporter from rat parathyroid glands. |journal=Endocrinology |volume=139 |issue= 4 |pages= 1692–9 |year= 1998 |pmid= 9528951 |doi=10.1210/endo.139.4.5925 |doi-access=free }}
*{{cite journal | author=Johann SV, van Zeijl M, Cekleniak J, O'Hara B |title=Definition of a domain of GLVR1 which is necessary for infection by gibbon ape leukemia virus and which is highly polymorphic between species. |journal=J. Virol. |volume=67 |issue= 11 |pages= 6733–6 |year= 1993 |pmid= 8411375 |doi= | pmc=238113 }}
*{{cite journal | vauthors=Palmer G, Manen D, Bonjour JP, Caverzasio J |title=Characterization of the human Glvr-1 phosphate transporter/retrovirus receptor gene and promoter region. |journal=Gene |volume=226 |issue= 1 |pages= 25–33 |year= 1999 |pmid= 9889306 |doi=10.1016/S0378-1119(98)00572-1 }}
*{{cite journal | author=Tatsumi S, Segawa H, Morita K, ''et al.'' |title=Molecular cloning and hormonal regulation of PiT-1, a sodium-dependent phosphate cotransporter from rat parathyroid glands. |journal=Endocrinology |volume=139 |issue= 4 |pages= 1692–9 |year= 1998 |pmid= 9528951 |doi=10.1210/en.139.4.1692 }}
*{{cite journal |vauthors=Jono S, McKee MD, Murry CE, etal |title=Phosphate regulation of vascular smooth muscle cell calcification. |journal=Circ. Res. |volume=87 |issue= 7 |pages= E10–7 |year= 2000 |pmid= 11009570 |doi= 10.1161/01.RES.87.7.e10 |doi-access= free }}
*{{cite journal | author=Palmer G, Manen D, Bonjour JP, Caverzasio J |title=Characterization of the human Glvr-1 phosphate transporter/retrovirus receptor gene and promoter region. |journal=Gene |volume=226 |issue= 1 |pages= 25–33 |year= 1999 |pmid= 9889306 |doi=10.1016/S0378-1119(98)00572-1 }}
*{{cite journal | vauthors=Farrell KB, Russ JL, Murthy RK, Eiden MV |title=Reassessing the role of region A in Pit1-mediated viral entry. |journal=J. Virol. |volume=76 |issue= 15 |pages= 7683–93 |year= 2002 |pmid= 12097582 |doi=10.1128/JVI.76.15.7683-7693.2002 | pmc=136385 }}
*{{cite journal | author=Jono S, McKee MD, Murry CE, ''et al.'' |title=Phosphate regulation of vascular smooth muscle cell calcification. |journal=Circ. Res. |volume=87 |issue= 7 |pages= E10–7 |year= 2000 |pmid= 11009570 |doi= }}
*{{cite journal | vauthors=Bottger P, Pedersen L |title=Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42741–7 |year= 2003 |pmid= 12205090 |doi= 10.1074/jbc.M207096200 |doi-access= free }}
*{{cite journal | author=Farrell KB, Russ JL, Murthy RK, Eiden MV |title=Reassessing the role of region A in Pit1-mediated viral entry. |journal=J. Virol. |volume=76 |issue= 15 |pages= 7683–93 |year= 2002 |pmid= 12097582 |doi=10.1128/JVI.76.15.7683-7693.2002 | pmc=136385 }}
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal | author=Bottger P, Pedersen L |title=Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function. |journal=J. Biol. Chem. |volume=277 |issue= 45 |pages= 42741–7 |year= 2003 |pmid= 12205090 |doi= 10.1074/jbc.M207096200 }}
*{{cite journal |vauthors=Matsuda A, Suzuki Y, Honda G, etal |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. |journal=Oncogene |volume=22 |issue= 21 |pages= 3307–18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406 |doi-access= free }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Matsuda A, Suzuki Y, Honda G, ''et al.'' |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. |journal=Oncogene |volume=22 |issue= 21 |pages= 3307–18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406 }}
*{{cite journal | vauthors=Cecil DL, Rose DM, Terkeltaub R, Liu-Bryan R |title=Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes. |journal=Arthritis Rheum. |volume=52 |issue= 1 |pages= 144–54 |year= 2005 |pmid= 15641067 |doi= 10.1002/art.20748 |doi-access= free }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |bibcode=2005Natur.434..724H |doi-access= free }}
*{{cite journal | author=Cecil DL, Rose DM, Terkeltaub R, Liu-Bryan R |title=Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes. |journal=Arthritis Rheum. |volume=52 |issue= 1 |pages= 144–54 |year= 2005 |pmid= 15641067 |doi= 10.1002/art.20748 }}
*{{cite journal | vauthors=Li X, Yang HY, Giachelli CM |title=Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification. |journal=Circ. Res. |volume=98 |issue= 7 |pages= 905–12 |year= 2006 |pmid= 16527991 |doi= 10.1161/01.RES.0000216409.20863.e7 |doi-access= free }}
*{{cite journal | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal |vauthors=Bøttger P, Hede SE, Grunnet M, etal |title=Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2. |journal=Am. J. Physiol., Cell Physiol. |volume=291 |issue= 6 |pages= C1377–87 |year= 2007 |pmid= 16790504 |doi= 10.1152/ajpcell.00015.2006 }}
*{{cite journal | author=Li X, Yang HY, Giachelli CM |title=Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification. |journal=Circ. Res. |volume=98 |issue= 7 |pages= 905–12 |year= 2006 |pmid= 16527991 |doi= 10.1161/01.RES.0000216409.20863.e7 }}
*{{cite journal | author=Bøttger P, Hede SE, Grunnet M, ''et al.'' |title=Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2. |journal=Am. J. Physiol., Cell Physiol. |volume=291 |issue= 6 |pages= C1377–87 |year= 2007 |pmid= 16790504 |doi= 10.1152/ajpcell.00015.2006 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{Membrane transport proteins}}

[[Category:Solute carrier family]]
[[Category:Solute carrier family]]



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Latest revision as of 21:30, 3 March 2023

SLC20A1
Identifiers
AliasesSLC20A1, GLVR1, Glvr-1, PIT1, PiT-1, solute carrier family 20 member 1
External IDsOMIM: 137570; MGI: 108392; HomoloGene: 38049; GeneCards: SLC20A1; OMA:SLC20A1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005415

NM_001159593
NM_015747
NM_001355252

RefSeq (protein)

NP_005406

NP_001153065
NP_056562
NP_001342181

Location (UCSC)Chr 2: 112.65 – 112.66 MbChr 2: 129.04 – 129.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sodium-dependent phosphate transporter 1 is a protein that in humans is encoded by the SLC20A1 gene.[5][6]

Retrovirus receptors allow infection of human and murine cells by various retroviruses. The receptors that have been identified at the molecular level include CD4 (MIM 186940) for human immunodeficiency virus, Rec1 for murine ecotropic virus, and GLVR1 for gibbon ape leukemia virus (see MIM 182090). These 3 proteins show no homology to one another at the DNA or protein level. GLVR1 is a sodium-dependent phosphate symporter.[supplied by OMIM][6]

Research[edit]

It was reported that mutations of the gene may cause epispadias or bladder exstrophy.[7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144136Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027397Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kavanaugh MP, Miller DG, Zhang W, Law W, Kozak SL, Kabat D, Miller AD (Aug 1994). "Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters". Proc Natl Acad Sci U S A. 91 (15): 7071–5. Bibcode:1994PNAS...91.7071K. doi:10.1073/pnas.91.15.7071. PMC 44340. PMID 8041748.
  6. ^ a b "Entrez Gene: SLC20A1 solute carrier family 20 (phosphate transporter), member 1".
  7. ^ Rieke JM, Zhang R, Braun D, Yilmaz Ö, Japp AS, Lopes FM, et al. (2020). "SLC20A1 Is Involved in Urinary Tract and Urorectal Development". Frontiers in Cell and Developmental Biology. 8: 567. doi:10.3389/fcell.2020.00567. PMC 7426641. PMID 32850778.

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.