SLC2A6: Difference between revisions

SLC2A6
Identifiers
Aliases	SLC2A6, GLUT6, GLUT9, HSA011372, solute carrier family 2 member 6
External IDs	OMIM: 606813; MGI: 2443286; HomoloGene: 69236; GeneCards: SLC2A6; OMA:SLC2A6 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	133,479,127 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	26,918,010 bp
RNA expression pattern
	Top expressed in
	monocyte; ; prefrontal cortex; ; Brodmann area 9; ; blood; ; superior frontal gyrus; ; hypothalamus; ; spleen; ; substantia nigra; ; hippocampus proper; ; putamen;
	Top expressed in
	superior frontal gyrus; ; facial motor nucleus; ; blood; ; cerebellar cortex; ; morula; ; hippocampus proper; ; anterior horn of spinal cord; ; neural tube; ; bone marrow; ; prefrontal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glucose transmembrane transporter activity; carbohydrate:proton symporter activity; transmembrane transporter activity; transporter activity; D-glucose transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	carbohydrate transport; glucose import; transmembrane transport; hexose transmembrane transport; proton transmembrane transport; glucose transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	11182
	227659
	ENSG00000160326; ENSG00000281165
	ENSMUSG00000036067
	Q9UGQ3
	Q3UDF0
	NM_001145099; NM_017585
	NM_001177627; NM_172659
	NP_001138571; NP_060055
	NP_001171098; NP_766247
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 00:18, 4 March 2023

Solute carrier family 2, facilitated glucose transporter member 6 is a protein that in humans is encoded by the SLC2A6 gene.^[5]^[6]

Function[edit]

Hexose transport into mammalian cells is catalyzed by a family of membrane proteins, including SLC2A6, that contain 12 transmembrane domains and a number of critical conserved residues.[supplied by OMIM]^[6]

References[edit]

^ ^a ^b ^c ENSG00000281165 GRCh38: Ensembl release 89: ENSG00000160326, ENSG00000281165 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036067 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Doege H, Bocianski A, Joost HG, Schürmann A (September 2000). "Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes". The Biochemical Journal. 350 Pt 3 (Pt 3): 771–6. doi:10.1042/0264-6021:3500771. PMC 1221309. PMID 10970791.
^ ^a ^b "Entrez Gene: SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6".

Further reading[edit]

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Richardson S, Neama G, Phillips T, Bell S, Carter SD, Moley KH, Moley JF, Vannucci SJ, Mobasheri A (February 2003). "Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation". Osteoarthritis and Cartilage. 11 (2): 92–101. doi:10.1053/joca.2002.0858. PMID 12554125.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000281165 GRCh38: Ensembl release 89: ENSG00000160326, ENSG00000281165 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036067 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10970791-5] Doege H, Bocianski A, Joost HG, Schürmann A (September 2000). "Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes". The Biochemical Journal. 350 Pt 3 (Pt 3): 771–6. doi:10.1042/0264-6021:3500771. PMC 1221309. PMID 10970791.

[entrez-6] "Entrez Gene: SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6".

[1]

[2]

[3]

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[6]

@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB|geneid=11182}}
+{{Infobox_gene}}
-'''Solute carrier family 2 (facilitated glucose transporter), member 6''', also known as '''SLC2A6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11182| accessdate = }}</ref>
+'''Solute carrier family 2, facilitated glucose transporter member 6''' is a [[protein]] that in humans is encoded by the ''SLC2A6'' [[gene]].<ref name="pmid10970791">{{cite journal | vauthors = Doege H, Bocianski A, Joost HG, Schürmann A | title = Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes | journal = The Biochemical Journal | volume = 350 Pt 3 | issue = Pt 3 | pages = 771–6 | date = September 2000 | pmid = 10970791 | pmc = 1221309 | doi = 10.1042/0264-6021:3500771 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11182}}</ref>
+== Function ==
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = Hexose transport into mammalian cells is catalyzed by a family of membrane proteins, including SLC2A6, that contain 12 transmembrane domains and a number of critical conserved residues.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11182| accessdate = }}</ref>
-}}
+Hexose transport into mammalian cells is catalyzed by a family of membrane proteins, including SLC2A6, that contain 12 transmembrane domains and a number of critical conserved residues.[supplied by OMIM]<ref name="entrez" />
-==See also==
+== See also ==
 * [[Glucose transporter]]
 * [[Solute carrier family]]
-==References==
+== References ==
 {{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
+* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
-| citations =
+* {{cite journal | vauthors = Richardson S, Neama G, Phillips T, Bell S, Carter SD, Moley KH, Moley JF, Vannucci SJ, Mobasheri A | title = Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation | journal = Osteoarthritis and Cartilage | volume = 11 | issue = 2 | pages = 92–101 | date = February 2003 | pmid = 12554125 | doi = 10.1053/joca.2002.0858 | doi-access = free }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=  }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=  }}
+* {{cite journal | vauthors = Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T | title = Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries | journal = DNA Research | volume = 12 | issue = 2 | pages = 117–26 | year = 2007 | pmid = 16303743 | doi = 10.1093/dnares/12.2.117 | doi-access = free }}
-*{{cite journal  | author=Doege H, Bocianski A, Joost HG, Schürmann A |title=Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes. |journal=Biochem. J. |volume=350 Pt 3 |issue=  |pages= 771–6 |year= 2001 |pmid= 10970791 |doi=  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Richardson S, Neama G, Phillips T, ''et al.'' |title=Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation. |journal=Osteoarthr. Cartil. |volume=11 |issue= 2 |pages= 92–101 |year= 2003 |pmid= 12554125 |doi=  }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
-}}
 {{refend}}
-{{membrane-protein-stub}}
 {{NLM content}}
+{{Solute carrier family|bg|bg0}}
-{{Membrane transport proteins}}
 [[Category:Solute carrier family]]
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{membrane-protein-stub}}
-{{PBB_Controls
-| update_page = yes
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Latest revision as of 00:18, 4 March 2023

Function[edit]

See also[edit]

References[edit]

Further reading[edit]