Long-chain fatty acid transport protein 1: Difference between revisions
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{{Short description|Protein-coding gene in the species Homo sapiens}} |
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{{Infobox_gene}} |
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'''Long-chain fatty acid transport protein 1''' is a [[protein]] that in humans is encoded by the ''SLC27A1'' [[gene]].<ref name="pmid10873384">{{cite journal | vauthors = Martin G, Nemoto M, Gelman L, Geffroy S, Najib J, Fruchart JC, Roevens P, de Martinville B, Deeb S, Auwerx J | title = The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression | journal = Genomics | volume = 66 | issue = 3 | pages = 296–304 | date = June 2000 | pmid = 10873384 |
'''Long-chain fatty acid transport protein 1''' ('''FATP1''') is a [[protein]] that in humans is encoded by the ''SLC27A1'' [[gene]].<ref name="pmid10873384">{{cite journal | vauthors = Martin G, Nemoto M, Gelman L, Geffroy S, Najib J, Fruchart JC, Roevens P, de Martinville B, Deeb S, Auwerx J | title = The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression | journal = Genomics | volume = 66 | issue = 3 | pages = 296–304 | date = June 2000 | pmid = 10873384 | doi = 10.1006/geno.2000.6191 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC27A1 solute carrier family 27 (fatty acid transporter), member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=376497}}</ref> |
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== Structure == |
== Structure == |
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The SLC27A1 gene is located on the 19th chromosome, with its specific location being 19p13.11. The gene contains 15 exons.<ref name="entrez" /> SLC27A1 encodes a 71.1 kDa protein that is composed of 646 amino acids; 26 peptides have been observed through mass spectrometry data.<ref name=COPaKB>]{{cite journal | vauthors = Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P | title = Integration of cardiac proteome biology and medicine by a specialized knowledgebase | journal = Circulation Research | volume = 113 | issue = 9 | pages = 1043–53 | date = October 2013 | pmid = 23965338 | pmc = 4076475 | doi = 10.1161/CIRCRESAHA.113.301151 }}</ref><ref name="url_COPaKB">{{cite web | url = http://www.heartproteome.org/copa/ProteinInfo.aspx?QType=Protein%20ID&QValue=QQ6PCB7 | work = Cardiac Organellar Protein Atlas Knowledgebase (COPaKB) | title = Long-chain fatty acid transport protein 1}}</ref> |
The ''SLC27A1'' gene is located on the 19th chromosome, with its specific location being 19p13.11. The gene contains 15 exons.<ref name="entrez" /> SLC27A1 encodes a 71.1 kDa protein that is composed of 646 amino acids; 26 peptides have been observed through mass spectrometry data.<ref name=COPaKB>]{{cite journal | vauthors = Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P | title = Integration of cardiac proteome biology and medicine by a specialized knowledgebase | journal = Circulation Research | volume = 113 | issue = 9 | pages = 1043–53 | date = October 2013 | pmid = 23965338 | pmc = 4076475 | doi = 10.1161/CIRCRESAHA.113.301151 }}</ref><ref name="url_COPaKB">{{cite web | url = http://www.heartproteome.org/copa/ProteinInfo.aspx?QType=Protein%20ID&QValue=QQ6PCB7 | work = Cardiac Organellar Protein Atlas Knowledgebase (COPaKB) | title = Long-chain fatty acid transport protein 1}}</ref> |
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== See also == |
== See also == |
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== Further reading == |
== Further reading == |
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{{refbegin | 2}} |
{{refbegin | 2}} |
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* {{cite journal | vauthors = Meirhaeghe A, Cottel D, Amouyel P, Dallongeville J | title = Lack of association between certain candidate gene polymorphisms and the metabolic syndrome | journal = Molecular Genetics and Metabolism | volume = 86 | issue = |
* {{cite journal | vauthors = Meirhaeghe A, Cottel D, Amouyel P, Dallongeville J | title = Lack of association between certain candidate gene polymorphisms and the metabolic syndrome | journal = Molecular Genetics and Metabolism | volume = 86 | issue = 1–2 | pages = 293–9 | year = 2006 | pmid = 15978856 | doi = 10.1016/j.ymgme.2005.05.006 }} |
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* {{cite journal | vauthors = García-Martínez C, Marotta M, Moore-Carrasco R, Guitart M, Camps M, Busquets S, Montell E, Gómez-Foix AM | title = Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells | journal = American Journal of Physiology. Cell Physiology | volume = 288 | issue = 6 | pages = C1264-72 | date = June 2005 | pmid = 15897321 | doi = 10.1152/ajpcell.00271.2004 }} |
* {{cite journal | vauthors = García-Martínez C, Marotta M, Moore-Carrasco R, Guitart M, Camps M, Busquets S, Montell E, Gómez-Foix AM | title = Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells | journal = American Journal of Physiology. Cell Physiology | volume = 288 | issue = 6 | pages = C1264-72 | date = June 2005 | pmid = 15897321 | doi = 10.1152/ajpcell.00271.2004 }} |
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* {{cite journal | vauthors = Gertow K, Skoglund-Andersson C, Eriksson P, Boquist S, Orth-Gomér K, Schenck-Gustafsson K, Hamsten A, Fisher RM | title = A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution | journal = Atherosclerosis | volume = 167 | issue = 2 | pages = 265–73 | date = April 2003 | pmid = 12818409 | doi = 10.1016/S0021-9150(02)00454-9 }} |
* {{cite journal | vauthors = Gertow K, Skoglund-Andersson C, Eriksson P, Boquist S, Orth-Gomér K, Schenck-Gustafsson K, Hamsten A, Fisher RM | title = A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution | journal = Atherosclerosis | volume = 167 | issue = 2 | pages = 265–73 | date = April 2003 | pmid = 12818409 | doi = 10.1016/S0021-9150(02)00454-9 }} |
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* {{cite journal | vauthors = Hatch GM, Smith AJ, Xu FY, Hall AM, Bernlohr DA | title = FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells | journal = Journal of Lipid Research | volume = 43 | issue = 9 | pages = 1380–9 | date = September 2002 | pmid = 12235169 | doi = 10.1194/jlr.M200130-JLR200 }} |
* {{cite journal | vauthors = Hatch GM, Smith AJ, Xu FY, Hall AM, Bernlohr DA | title = FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells | journal = Journal of Lipid Research | volume = 43 | issue = 9 | pages = 1380–9 | date = September 2002 | pmid = 12235169 | doi = 10.1194/jlr.M200130-JLR200 | doi-access = free }} |
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* {{cite journal | vauthors = Hirsch D, Stahl A, Lodish HF | title = A family of fatty acid transporters conserved from mycobacterium to man | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 15 | pages = 8625–9 | date = July 1998 | pmid = 9671728 | pmc = 21126 | doi = 10.1073/pnas.95.15.8625 }} |
* {{cite journal | vauthors = Hirsch D, Stahl A, Lodish HF | title = A family of fatty acid transporters conserved from mycobacterium to man | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 15 | pages = 8625–9 | date = July 1998 | pmid = 9671728 | pmc = 21126 | doi = 10.1073/pnas.95.15.8625 | bibcode = 1998PNAS...95.8625H | doi-access = free }} |
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* {{cite journal | vauthors = Schaffer JE, Lodish HF | title = Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein | journal = Cell | volume = 79 | issue = 3 | pages = 427–36 | date = November 1994 | pmid = 7954810 | doi = 10.1016/0092-8674(94)90252-6 }} |
* {{cite journal | vauthors = Schaffer JE, Lodish HF | title = Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein | journal = Cell | volume = 79 | issue = 3 | pages = 427–36 | date = November 1994 | pmid = 7954810 | doi = 10.1016/0092-8674(94)90252-6 | s2cid = 20637905 }} |
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{{refend}} |
{{refend}} |
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[[Category:Solute carrier family]] |
[[Category:Solute carrier family]] |
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{{membrane-protein-stub}} |
{{membrane-protein-stub}} |
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Latest revision as of 22:27, 7 December 2023
Long-chain fatty acid transport protein 1 (FATP1) is a protein that in humans is encoded by the SLC27A1 gene.[5][6]
Structure[edit]
The SLC27A1 gene is located on the 19th chromosome, with its specific location being 19p13.11. The gene contains 15 exons.[6] SLC27A1 encodes a 71.1 kDa protein that is composed of 646 amino acids; 26 peptides have been observed through mass spectrometry data.[7][8]
See also[edit]
- SLC27A1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Solute carrier family
References[edit]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000130304 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031808 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Martin G, Nemoto M, Gelman L, Geffroy S, Najib J, Fruchart JC, Roevens P, de Martinville B, Deeb S, Auwerx J (June 2000). "The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression". Genomics. 66 (3): 296–304. doi:10.1006/geno.2000.6191. PMID 10873384.
- ^ a b "Entrez Gene: SLC27A1 solute carrier family 27 (fatty acid transporter), member 1".
- ^ ]Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (October 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
- ^ "Long-chain fatty acid transport protein 1". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).
Further reading[edit]
- Meirhaeghe A, Cottel D, Amouyel P, Dallongeville J (2006). "Lack of association between certain candidate gene polymorphisms and the metabolic syndrome". Molecular Genetics and Metabolism. 86 (1–2): 293–9. doi:10.1016/j.ymgme.2005.05.006. PMID 15978856.
- García-Martínez C, Marotta M, Moore-Carrasco R, Guitart M, Camps M, Busquets S, Montell E, Gómez-Foix AM (June 2005). "Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells". American Journal of Physiology. Cell Physiology. 288 (6): C1264-72. doi:10.1152/ajpcell.00271.2004. PMID 15897321.
- Gertow K, Skoglund-Andersson C, Eriksson P, Boquist S, Orth-Gomér K, Schenck-Gustafsson K, Hamsten A, Fisher RM (April 2003). "A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution". Atherosclerosis. 167 (2): 265–73. doi:10.1016/S0021-9150(02)00454-9. PMID 12818409.
- Hatch GM, Smith AJ, Xu FY, Hall AM, Bernlohr DA (September 2002). "FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells". Journal of Lipid Research. 43 (9): 1380–9. doi:10.1194/jlr.M200130-JLR200. PMID 12235169.
- Hirsch D, Stahl A, Lodish HF (July 1998). "A family of fatty acid transporters conserved from mycobacterium to man". Proceedings of the National Academy of Sciences of the United States of America. 95 (15): 8625–9. Bibcode:1998PNAS...95.8625H. doi:10.1073/pnas.95.15.8625. PMC 21126. PMID 9671728.
- Schaffer JE, Lodish HF (November 1994). "Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein". Cell. 79 (3): 427–36. doi:10.1016/0092-8674(94)90252-6. PMID 7954810. S2CID 20637905.
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