Urea transporter 2: Difference between revisions

SLC14A2
Identifiers
Aliases	SLC14A2, HUT2, UT-A2, UT2, UTA, UTR, hUT-A6, solute carrier family 14 member 2
External IDs	OMIM: 601611; MGI: 1351653; HomoloGene: 5183; GeneCards: SLC14A2; OMA:SLC14A2 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	45,683,688 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	78,640,157 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; left adrenal gland; ; Achilles tendon; ; kidney; ; appendix; ; subcutaneous adipose tissue; ; ganglionic eminence; ; right lung; ; right coronary artery; ; left coronary artery;
	Top expressed in
	inner renal medulla; ; respiratory epithelium; ; olfactory epithelium; ; thin ascending limb of loop of Henle; ; kidney; ; inner stripe of outer renal medulla; ; seminiferous tubule; ; pretectal area; ; proximal convoluted tubule; ; right ventricle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	urea transmembrane transporter activity; cell adhesion molecule binding; protein binding; urea channel activity;
Cellular component	apical plasma membrane; plasma membrane; membrane; integral component of membrane; integral component of plasma membrane;
Biological process	urea transmembrane transport; transmembrane transport; urea transport;
	Sources:Amigo / QuickGO
Orthologs
	8170
	27411
	ENSG00000132874
	ENSMUSG00000024552
	Q15849
	Q8R4T9
	NM_001242692; NM_007163; NM_001371319
	NM_001110273; NM_001110274; NM_030683; NM_207651
	NP_001229621; NP_009094; NP_001358248
	NP_001103743; NP_001103744; NP_109608; NP_997534
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 02:30, 27 December 2023

Urea transporter 2 is a protein that in humans is encoded by the SLC14A2 gene.^[5]^[6]

Function[edit]

In mammalian cells, urea is the chief end-product of nitrogen catabolism and plays an important role in the urinary concentration mechanism. Thus, the plasma membrane of erythrocytes and some renal epithelial cells exhibit an elevated urea permeability that is mediated by highly selective urea transporters. In mammals, two urea transporters have been identified: the renal tubular urea transporter, UT2 (UT-A), and the erythrocyte urea transporter, UT11 (also called UT-B, coded for by the SLC14A1 gene).^[6] SLC14A2 and SLC14A1 constitute solute carrier family 14.

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132874 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024552 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Olives B, Martial S, Mattei MG, Matassi G, Rousselet G, Ripoche P, Cartron JP, Bailly P (Jul 1996). "Molecular characterization of a new urea transporter in the human kidney" (PDF). FEBS Lett. 386 (2–3): 156–60. doi:10.1016/0014-5793(96)00425-5. PMID 8647271. S2CID 13312002.
^ ^a ^b "Entrez Gene: SLC14A2 solute carrier family 14 (urea transporter), member 2".

Further reading[edit]

Smith CP, Fenton RA (2007). "Genomic organization of the mammalian SLC14a2 urea transporter genes". J. Membr. Biol. 212 (2): 109–17. doi:10.1007/s00232-006-0870-z. PMID 17264986. S2CID 12514783.
Olives B, Neau P, Bailly P, et al. (1995). "Cloning and functional expression of a urea transporter from human bone marrow cells". J. Biol. Chem. 269 (50): 31649–52. doi:10.1016/S0021-9258(18)31744-7. PMID 7989337.
Bradford AD, Terris JM, Ecelbarger CA, et al. (2001). "97- and 117-kDa forms of collecting duct urea transporter UT-A1 are due to different states of glycosylation". Am. J. Physiol. Renal Physiol. 281 (1): F133–43. doi:10.1152/ajprenal.2001.281.1.F133. PMID 11399654. S2CID 393209.
Bagnasco SM, Peng T, Janech MG, et al. (2001). "Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene". Am. J. Physiol. Renal Physiol. 281 (3): F400–6. doi:10.1152/ajprenal.2001.281.3.F400. PMID 11502588. S2CID 17458312.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Jung JY, Madsen KM, Han KH, et al. (2003). "Expression of urea transporters in potassium-depleted mouse kidney". Am. J. Physiol. Renal Physiol. 285 (6): F1210–24. doi:10.1152/ajprenal.00111.2003. PMID 12952854.
Smith CP, Potter EA, Fenton RA, Stewart GS (2004). "Characterization of a human colonic cDNA encoding a structurally novel urea transporter, hUT-A6". Am. J. Physiol., Cell Physiol. 287 (4): C1087–93. doi:10.1152/ajpcell.00363.2003. PMID 15189812. S2CID 26010752.
Damiano AE, Zotta E, Ibarra C (2006). "Functional and molecular expression of AQP9 channel and UT-A transporter in normal and preeclamptic human placentas". Placenta. 27 (11–12): 1073–81. doi:10.1016/j.placenta.2005.11.014. PMID 16480766.
Hong X, Xing H, Yu Y, et al. (2007). "Genetic polymorphisms of the urea transporter gene are associated with antihypertensive response to nifedipine GITS". Methods and Findings in Experimental and Clinical Pharmacology. 29 (1): 3–10. doi:10.1358/mf.2007.29.1.1063490. PMID 17344938.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132874 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024552 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8647271-5] Olives B, Martial S, Mattei MG, Matassi G, Rousselet G, Ripoche P, Cartron JP, Bailly P (Jul 1996). "Molecular characterization of a new urea transporter in the human kidney" (PDF). FEBS Lett. 386 (2–3): 156–60. doi:10.1016/0014-5793(96)00425-5. PMID 8647271. S2CID 13312002.

[entrez-6] "Entrez Gene: SLC14A2 solute carrier family 14 (urea transporter), member 2".

[1]

[2]

[3]

[4]

[5]

[6]

@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Urea transporter 2''' is a [[protein]] that in humans is encoded by the ''SLC14A2'' [[gene]].<ref name="pmid8647271">{{cite journal | vauthors = Olives B, Martial S, Mattei MG, Matassi G, Rousselet G, Ripoche P, Cartron JP, Bailly P | title = Molecular characterization of a new urea transporter in the human kidney | journal = FEBS Lett | volume = 386 | issue = 2–3 | pages = 156–60 |date=Jul 1996 | pmid = 8647271 | doi =10.1016/0014-5793(96)00425-5  | s2cid = 13312002 | url = https://hal.archives-ouvertes.fr/hal-02376236/file/Olive%CC%80s%20-%201996%20-%20Human%20kidney%20urea%20transporter.pdf }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC14A2 solute carrier family 14 (urea transporter), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8170}}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
+== Function ==
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 14 (urea transporter), member 2
- | HGNCid = 10919
- | Symbol = SLC14A2
- | AltSymbols =; UTR; FLJ16167; HUT2; MGC119566; MGC119567; UT-A2; UT2; hUT-A6
- | OMIM = 601611
- | ECnumber =
- | Homologene = 5183
- | MGIid = 1351653
- | GeneAtlas_image1 = PBB_GE_SLC14A2_208409_at_tn.png
- | GeneAtlas_image2 = PBB_GE_SLC14A2_gnf1h08037_at_tn.png
- | Function = {{GNF_GO|id=GO:0015204 |text = urea transporter activity}}
- | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0015840 |text = urea transport}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 8170
-    | Hs_Ensembl = ENSG00000132874
-    | Hs_RefseqProtein = NP_009094
-    | Hs_RefseqmRNA = NM_007163
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 18
-    | Hs_GenLoc_start = 41458628
-    | Hs_GenLoc_end = 41516482
-    | Hs_Uniprot = Q15849
-    | Mm_EntrezGene = 27411
-    | Mm_Ensembl = ENSMUSG00000024552
-    | Mm_RefseqmRNA = NM_030683
-    | Mm_RefseqProtein = NP_109608
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 18
-    | Mm_GenLoc_start = 78308224
-    | Mm_GenLoc_end = 78488490
-    | Mm_Uniprot =
-  }}
-}}
-'''Solute carrier family 14 (urea transporter), member 2''', also known as '''SLC14A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC14A2 solute carrier family 14 (urea transporter), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8170| accessdate = }}</ref>
+In [[mammal]]ian cells, [[urea]] is the chief end-product of [[nitrogen]] [[catabolism]] and plays an important role in the [[Countercurrent multiplication|urinary concentration]] mechanism. Thus, the [[plasma membrane]] of [[erythrocyte]]s and some [[Kidney tubule#Renal tubule|renal]] [[Epithelium|epithelial]] cells exhibit an elevated urea [[Membrane transport|permeability]] that is mediated by highly selective [[urea transporter]]s. In mammals, two urea transporters have been identified: the renal tubular urea transporter, UT2 ([[Urea transporter|UT-A]]), and the erythrocyte urea transporter, UT11 (also called [[Urea transporter#Urea Transporter B|UT-B]], coded for by the [[SLC14A1]] gene).<ref name="entrez"/> SLC14A2 and [[SLC14A1]] constitute [[solute carrier family]] 14.
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = In mammalian cells, urea is the chief end-product of nitrogen catabolism and plays an important role in the urinary concentration mechanism. Thus, the plasma membrane of erythrocytes and some renal epithelial cells exhibit an elevated urea permeability that is mediated by highly selective urea transporters. In mammals, 2 urea transporters have been identified: the renal tubular urea transporter, UT2, and the erythrocyte urea transporter, UT11 (SLC14A1; MIM 111000).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SLC14A2 solute carrier family 14 (urea transporter), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8170| accessdate = }}</ref>
-}}
 ==References==
 {{reflist}}
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal  | vauthors=Smith CP, Fenton RA |title=Genomic organization of the mammalian SLC14a2 urea transporter genes. |journal=J. Membr. Biol. |volume=212 |issue= 2 |pages= 109–17 |year= 2007 |pmid= 17264986 |doi= 10.1007/s00232-006-0870-z |s2cid=12514783 }}
-{{PBB_Further_reading
+*{{cite journal   |vauthors=Olives B, Neau P, Bailly P, etal |title=Cloning and functional expression of a urea transporter from human bone marrow cells. |journal=J. Biol. Chem. |volume=269 |issue= 50 |pages= 31649–52 |year= 1995 |doi=10.1016/S0021-9258(18)31744-7 |pmid= 7989337 |doi-access=free }}
-| citations =
-*{{cite journal  | author=Smith CP, Fenton RA |title=Genomic organization of the mammalian SLC14a2 urea transporter genes. |journal=J. Membr. Biol. |volume=212 |issue= 2 |pages= 109-17 |year= 2007 |pmid= 17264986 |doi= 10.1007/s00232-006-0870-z }}
+*{{cite journal   |vauthors=Bradford AD, Terris JM, Ecelbarger CA, etal |title=97- and 117-kDa forms of collecting duct urea transporter UT-A1 are due to different states of glycosylation. |journal=Am. J. Physiol. Renal Physiol. |volume=281 |issue= 1 |pages= F133–43 |year= 2001 |pmid= 11399654 |doi=  10.1152/ajprenal.2001.281.1.F133|s2cid=393209 }}
-*{{cite journal  | author=Olives B, Neau P, Bailly P, ''et al.'' |title=Cloning and functional expression of a urea transporter from human bone marrow cells. |journal=J. Biol. Chem. |volume=269 |issue= 50 |pages= 31649-52 |year= 1995 |pmid= 7989337 |doi=  }}
+*{{cite journal   |vauthors=Bagnasco SM, Peng T, Janech MG, etal |title=Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene. |journal=Am. J. Physiol. Renal Physiol. |volume=281 |issue= 3 |pages= F400–6 |year= 2001 |pmid= 11502588 |doi=  10.1152/ajprenal.2001.281.3.F400|s2cid=17458312 }}
-*{{cite journal  | author=Olivès B, Martial S, Mattei MG, ''et al.'' |title=Molecular characterization of a new urea transporter in the human kidney. |journal=FEBS Lett. |volume=386 |issue= 2-3 |pages= 156-60 |year= 1996 |pmid= 8647271 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal  | author=Bradford AD, Terris JM, Ecelbarger CA, ''et al.'' |title=97- and 117-kDa forms of collecting duct urea transporter UT-A1 are due to different states of glycosylation. |journal=Am. J. Physiol. Renal Physiol. |volume=281 |issue= 1 |pages= F133-43 |year= 2001 |pmid= 11399654 |doi=  }}
+*{{cite journal   |vauthors=Jung JY, Madsen KM, Han KH, etal |title=Expression of urea transporters in potassium-depleted mouse kidney. |journal=Am. J. Physiol. Renal Physiol. |volume=285 |issue= 6 |pages= F1210–24 |year= 2003 |pmid= 12952854 |doi= 10.1152/ajprenal.00111.2003 }}
-*{{cite journal  | author=Bagnasco SM, Peng T, Janech MG, ''et al.'' |title=Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene. |journal=Am. J. Physiol. Renal Physiol. |volume=281 |issue= 3 |pages= F400-6 |year= 2001 |pmid= 11502588 |doi=  }}
+*{{cite journal  | vauthors=Smith CP, Potter EA, Fenton RA, Stewart GS |title=Characterization of a human colonic cDNA encoding a structurally novel urea transporter, hUT-A6. |journal=Am. J. Physiol., Cell Physiol. |volume=287 |issue= 4 |pages= C1087–93 |year= 2004 |pmid= 15189812 |doi= 10.1152/ajpcell.00363.2003 |s2cid=26010752 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Damiano AE, Zotta E, Ibarra C |title=Functional and molecular expression of AQP9 channel and UT-A transporter in normal and preeclamptic human placentas. |journal=Placenta |volume=27 |issue= 11–12 |pages= 1073–81 |year= 2006 |pmid= 16480766 |doi= 10.1016/j.placenta.2005.11.014 }}
-*{{cite journal  | author=Jung JY, Madsen KM, Han KH, ''et al.'' |title=Expression of urea transporters in potassium-depleted mouse kidney. |journal=Am. J. Physiol. Renal Physiol. |volume=285 |issue= 6 |pages= F1210-24 |year= 2003 |pmid= 12952854 |doi= 10.1152/ajprenal.00111.2003 }}
+*{{cite journal   |vauthors=Hong X, Xing H, Yu Y, etal |title=Genetic polymorphisms of the urea transporter gene are associated with antihypertensive response to nifedipine GITS. |journal=Methods and Findings in Experimental and Clinical Pharmacology |volume=29 |issue= 1 |pages= 3–10 |year= 2007 |pmid= 17344938 |doi= 10.1358/mf.2007.29.1.1063490 }}
-*{{cite journal  | author=Smith CP, Potter EA, Fenton RA, Stewart GS |title=Characterization of a human colonic cDNA encoding a structurally novel urea transporter, hUT-A6. |journal=Am. J. Physiol., Cell Physiol. |volume=287 |issue= 4 |pages= C1087-93 |year= 2004 |pmid= 15189812 |doi= 10.1152/ajpcell.00363.2003 }}
-*{{cite journal  | author=Damiano AE, Zotta E, Ibarra C |title=Functional and molecular expression of AQP9 channel and UT-A transporter in normal and preeclamptic human placentas. |journal=Placenta |volume=27 |issue= 11-12 |pages= 1073-81 |year= 2006 |pmid= 16480766 |doi= 10.1016/j.placenta.2005.11.014 }}
-*{{cite journal  | author=Hong X, Xing H, Yu Y, ''et al.'' |title=Genetic polymorphisms of the urea transporter gene are associated with antihypertensive response to nifedipine GITS. |journal=Methods and findings in experimental and clinical pharmacology |volume=29 |issue= 1 |pages= 3-10 |year= 2007 |pmid= 17344938 |doi= 10.1358/mf.2007.29.1.1063490 }}
-}}
 {{refend}}
-{{protein-stub}}
+{{NLM content}}
+{{Membrane transport proteins}}
+[[Category:Solute carrier family]]
+{{membrane-protein-stub}}