Solute carrier organic anion transporter family member 1A2: Difference between revisions
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'''Solute carrier organic anion transporter family member 1A2''' is a [[protein]] that in humans is encoded by the ''SLCO1A2'' [[gene]].<ref name="pmid9007731">{{cite journal | |
'''Solute carrier organic anion transporter family member 1A2''' is a [[protein]] that in humans is encoded by the ''SLCO1A2'' [[gene]].<ref name="pmid9007731">{{cite journal | vauthors = Kullak-Ublick GA, Beuers U, Meier PJ, Domdey H, Paumgartner G | title = Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization | journal = J Hepatol | volume = 25 | issue = 6 | pages = 985–7 |date=Apr 1997 | pmid = 9007731 | doi =10.1016/S0168-8278(96)80307-2 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLCO1A2 solute carrier organic anion transporter family, member 1A2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6579}}</ref> |
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⚫ | This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternate splicing of this gene results in three transcript variants encoding two different isoforms.<ref name="entrez" /> |
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==See also== |
==See also== |
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==Further reading== |
==Further reading== |
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*{{cite journal |vauthors=Meier PJ, Eckhardt U, Schroeder A, etal |title=Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver |journal=Hepatology |volume=26 |issue= 6 |pages= 1667–77 |year= 1998 |pmid= 9398014 |doi= 10.1002/hep.510260641 |s2cid=20039812 }} |
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⚫ | *{{cite journal |vauthors=Kullak-Ublick GA, Hagenbuch B, Stieger B, etal |title=Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver |journal=Gastroenterology |volume=109 |issue= 4 |pages= 1274–82 |year= 1995 |pmid= 7557095 |doi=10.1016/0016-5085(95)90588-X }} |
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*{{cite journal |
*{{cite journal |vauthors=Kullak-Ublick GA, Beuers U, Fahney C, etal |title=Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene |journal=Hepatology |volume=26 |issue= 4 |pages= 991–7 |year= 1997 |pmid= 9328325 |doi= 10.1002/hep.510260429 |s2cid=43606355 |doi-access= }} |
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*{{cite journal |
*{{cite journal |vauthors=Kullak-Ublick GA, Fisch T, Oswald M, etal |title=Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain |journal=FEBS Lett. |volume=424 |issue= 3 |pages= 173–6 |year= 1998 |pmid= 9539145 |doi=10.1016/S0014-5793(98)00168-9 |s2cid=21231745 |doi-access=free }} |
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*{{cite journal | |
*{{cite journal | vauthors=König J, Cui Y, Nies AT, Keppler D |title=Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23161–8 |year= 2000 |pmid= 10779507 |doi= 10.1074/jbc.M001448200 |doi-access= free }} |
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*{{cite journal |
*{{cite journal |vauthors=Tamai I, Nezu J, Uchino H, etal |title=Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family |journal=Biochem. Biophys. Res. Commun. |volume=273 |issue= 1 |pages= 251–60 |year= 2000 |pmid= 10873595 |doi= 10.1006/bbrc.2000.2922 }} |
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⚫ | |||
*{{cite journal | author=Tamai I, Nezu J, Uchino H, ''et al.'' |title=Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family |journal=Biochem. Biophys. Res. Commun. |volume=273 |issue= 1 |pages= 251–60 |year= 2000 |pmid= 10873595 |doi= 10.1006/bbrc.2000.2922 }} |
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*{{cite journal | author=Speek M |title=Antisense Promoter of Human L1 Retrotransposon Drives Transcription of Adjacent Cellular Genes |journal=Mol. Cell. Biol. |volume=21 |issue= 6 |pages= 1973–85 |year= 2001 |pmid= 11238933 |doi= 10.1128/MCB.21.6.1973-1985.2001 | pmc=86790 }} |
*{{cite journal | author=Speek M |title=Antisense Promoter of Human L1 Retrotransposon Drives Transcription of Adjacent Cellular Genes |journal=Mol. Cell. Biol. |volume=21 |issue= 6 |pages= 1973–85 |year= 2001 |pmid= 11238933 |doi= 10.1128/MCB.21.6.1973-1985.2001 | pmc=86790 }} |
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*{{cite journal |
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} |
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*{{cite journal |
*{{cite journal |vauthors=Lee W, Glaeser H, Smith LH, etal |title=Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry |journal=J. Biol. Chem. |volume=280 |issue= 10 |pages= 9610–7 |year= 2005 |pmid= 15632119 |doi= 10.1074/jbc.M411092200 |doi-access= free }} |
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*{{cite journal | |
*{{cite journal | vauthors=Su Y, Zhang X, Sinko PJ |title=Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells |journal=Mol. Pharm. |volume=1 |issue= 1 |pages= 49–56 |year= 2005 |pmid= 15832500 |doi=10.1021/mp0340136 }} |
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*{{cite journal |
*{{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }} |
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{{refend}} |
{{refend}} |
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{{NLM content}} |
{{NLM content}} |
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{{Membrane transport proteins}} |
{{Membrane transport proteins}} |
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[[Category:Solute carrier family]] |
[[Category:Solute carrier family]] |
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[[Category: Thyroid hormone transporters]] |
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Latest revision as of 19:26, 31 December 2023
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | SLCO1A2, OATP, OATP-A, OATP1A2, SLC21A3, solute carrier organic anion transporter family member 1A2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 602883; MGI: 1351865; HomoloGene: 56603; GeneCards: SLCO1A2; OMA:SLCO1A2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.[5][6]
This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternate splicing of this gene results in three transcript variants encoding two different isoforms.[6]
See also[edit]
References[edit]
- ^ a b c GRCh38: Ensembl release 89: ENSG00000084453 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063975 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kullak-Ublick GA, Beuers U, Meier PJ, Domdey H, Paumgartner G (Apr 1997). "Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization". J Hepatol. 25 (6): 985–7. doi:10.1016/S0168-8278(96)80307-2. PMID 9007731.
- ^ a b "Entrez Gene: SLCO1A2 solute carrier organic anion transporter family, member 1A2".
Further reading[edit]
- Meier PJ, Eckhardt U, Schroeder A, et al. (1998). "Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver". Hepatology. 26 (6): 1667–77. doi:10.1002/hep.510260641. PMID 9398014. S2CID 20039812.
- Kullak-Ublick GA, Hagenbuch B, Stieger B, et al. (1995). "Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver". Gastroenterology. 109 (4): 1274–82. doi:10.1016/0016-5085(95)90588-X. PMID 7557095.
- Kullak-Ublick GA, Beuers U, Fahney C, et al. (1997). "Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene". Hepatology. 26 (4): 991–7. doi:10.1002/hep.510260429. PMID 9328325. S2CID 43606355.
- Kullak-Ublick GA, Fisch T, Oswald M, et al. (1998). "Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain". FEBS Lett. 424 (3): 173–6. doi:10.1016/S0014-5793(98)00168-9. PMID 9539145. S2CID 21231745.
- König J, Cui Y, Nies AT, Keppler D (2000). "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide". J. Biol. Chem. 275 (30): 23161–8. doi:10.1074/jbc.M001448200. PMID 10779507.
- Tamai I, Nezu J, Uchino H, et al. (2000). "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family". Biochem. Biophys. Res. Commun. 273 (1): 251–60. doi:10.1006/bbrc.2000.2922. PMID 10873595.
- Speek M (2001). "Antisense Promoter of Human L1 Retrotransposon Drives Transcription of Adjacent Cellular Genes". Mol. Cell. Biol. 21 (6): 1973–85. doi:10.1128/MCB.21.6.1973-1985.2001. PMC 86790. PMID 11238933.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lee W, Glaeser H, Smith LH, et al. (2005). "Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry". J. Biol. Chem. 280 (10): 9610–7. doi:10.1074/jbc.M411092200. PMID 15632119.
- Su Y, Zhang X, Sinko PJ (2005). "Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells". Mol. Pharm. 1 (1): 49–56. doi:10.1021/mp0340136. PMID 15832500.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.