SLC13A3: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''Solute carrier family 13 member 3''' also called '''sodium-dependent dicarboxylate transporter''' (NaDC3) is a [[protein]] that in humans is encoded by the ''SLC13A3'' [[gene]].<ref name="pmid10794676">{{cite journal | vauthors = Wang H, Fei YJ, Kekuda R, Yang-Feng TL, Devoe LD, Leibach FH, Prasad PD, Ganapathy V | title = Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter | journal = Am J Physiol Cell Physiol | volume = 278 | issue = 5 | pages = C1019–30 |date=Jun 2000 | pmid = 10794676 | doi = 10.1152/ajpcell.2000.278.5.C1019}}</ref><ref name="pmid10992006">{{cite journal | vauthors = Huang W, Wang H, Kekuda R, Fei YJ, Friedrich A, Wang J, Conway SJ, Cameron RS, Leibach FH, Ganapathy V | title = Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain | journal = J Pharmacol Exp Ther | volume = 295 | issue = 1 | pages = 392–403 |date=Nov 2000 | pmid = 10992006 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64849}}</ref>
'''Solute carrier family 13 member 3''' also called '''sodium-dependent dicarboxylate transporter''' (NaDC3) is a [[protein]] that in humans is encoded by the ''SLC13A3'' [[gene]].<ref name="pmid10794676">{{cite journal | vauthors = Wang H, Fei YJ, Kekuda R, Yang-Feng TL, Devoe LD, Leibach FH, Prasad PD, Ganapathy V | title = Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter | journal = Am J Physiol Cell Physiol | volume = 278 | issue = 5 | pages = C1019–30 |date=Jun 2000 | pmid = 10794676 | doi = 10.1152/ajpcell.2000.278.5.C1019| s2cid = 39532742 }}</ref><ref name="pmid10992006">{{cite journal | vauthors = Huang W, Wang H, Kekuda R, Fei YJ, Friedrich A, Wang J, Conway SJ, Cameron RS, Leibach FH, Ganapathy V | title = Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain | journal = J Pharmacol Exp Ther | volume = 295 | issue = 1 | pages = 392–403 |date=Nov 2000 | pmid = 10992006 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64849}}</ref>


Mammalian sodium-dicarboxylate [[cotransporter]]s transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.<ref name="entrez"/>
Mammalian sodium-dicarboxylate [[cotransporter]]s transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.<ref name="entrez"/>
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{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal | vauthors=Markovich D, Murer H |title=The SLC13 gene family of sodium sulphate/carboxylate cotransporters. |journal=Pflügers Arch. |volume=447 |issue= 5 |pages= 594–602 |year= 2004 |pmid= 12915942 |doi= 10.1007/s00424-003-1128-6 |s2cid=7609066 }}
*{{cite journal | vauthors=Markovich D, Murer H |title=The SLC13 gene family of sodium sulphate/carboxylate cotransporters. |journal=Pflügers Arch. |volume=447 |issue= 5 |pages= 594–602 |year= 2004 |pmid= 12915942 |doi= 10.1007/s00424-003-1128-6 |s2cid=7609066 }}
*{{cite journal |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |doi-access= free }}
*{{cite journal |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |bibcode=2001Natur.414..865D |doi-access= free }}
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |doi-access=free }}
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}

Revision as of 18:32, 14 October 2022

SLC13A3
Identifiers
AliasesSLC13A3, NADC3, SDCT2, solute carrier family 13 member 3, ARLIAK
External IDsOMIM: 606411; MGI: 2149635; HomoloGene: 11266; GeneCards: SLC13A3; OMA:SLC13A3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

64849

114644

Ensembl

ENSG00000158296

ENSMUSG00000018459

UniProt

Q8WWT9

Q91Y63

RefSeq (mRNA)

NM_022829
NM_001011554
NM_001193339
NM_001193340
NM_001193342

NM_054055

RefSeq (protein)

NP_001011554
NP_001180268
NP_001180269
NP_001180271
NP_073740

NP_473396

Location (UCSC)Chr 20: 46.56 – 46.68 MbChr 2: 165.25 – 165.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Solute carrier family 13 member 3 also called sodium-dependent dicarboxylate transporter (NaDC3) is a protein that in humans is encoded by the SLC13A3 gene.[5][6][7]

Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158296 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018459 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wang H, Fei YJ, Kekuda R, Yang-Feng TL, Devoe LD, Leibach FH, Prasad PD, Ganapathy V (Jun 2000). "Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter". Am J Physiol Cell Physiol. 278 (5): C1019–30. doi:10.1152/ajpcell.2000.278.5.C1019. PMID 10794676. S2CID 39532742.
  6. ^ Huang W, Wang H, Kekuda R, Fei YJ, Friedrich A, Wang J, Conway SJ, Cameron RS, Leibach FH, Ganapathy V (Nov 2000). "Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain". J Pharmacol Exp Ther. 295 (1): 392–403. PMID 10992006.
  7. ^ a b "Entrez Gene: SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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