Long-chain fatty acid transport protein 1: Difference between revisions

SLC27A1
Identifiers
Aliases	SLC27A1, ACSVL5, FATP, FATP1, FATP-1, solute carrier family 27 member 1
External IDs	OMIM: 600691; MGI: 1347098; HomoloGene: 8063; GeneCards: SLC27A1; OMA:SLC27A1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	17,506,168 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	71,587,302 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; sural nerve; ; tibialis anterior muscle; ; right uterine tube; ; amygdala; ; putamen; ; gastrocnemius muscle; ; substantia nigra; ; Brodmann area 9; ; canal of the cervix;
	Top expressed in
	superior frontal gyrus; ; lip; ; white adipose tissue; ; subcutaneous adipose tissue; ; right ventricle; ; brown adipose tissue; ; ascending aorta; ; entorhinal cortex; ; aortic valve; ; pituitary gland;
	More reference expression data
	n/a
Gene ontology
Molecular function	long-chain fatty acid-CoA ligase activity; nucleotide binding; protein homodimerization activity; ligase activity; catalytic activity; very long-chain fatty acid-CoA ligase activity; fatty acid transmembrane transporter activity; long-chain fatty acid transporter activity; protein binding;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; endoplasmic reticulum; endomembrane system; mitochondrion; mitochondrial inner membrane; cytosol; integral component of plasma membrane;
Biological process	phosphatidic acid biosynthetic process; phosphatidylserine biosynthetic process; lipid transport; lipid metabolism; medium-chain fatty acid transport; phosphatidylglycerol biosynthetic process; fatty acid transport; phosphatidylethanolamine biosynthetic process; adiponectin-activated signaling pathway; fatty acid metabolic process; positive regulation of protein serine/threonine kinase activity; response to insulin; negative regulation of phospholipid biosynthetic process; positive regulation of heat generation; cardiolipin biosynthetic process; phosphatidylinositol biosynthetic process; response to cold; phosphatidylcholine biosynthetic process; metabolism; long-chain fatty acid metabolic process; long-chain fatty acid transport; regulation of lipid metabolic process; transport; positive regulation of triglyceride biosynthetic process; long-chain fatty acid import into cell;
	Sources:Amigo / QuickGO
Orthologs
	376497
	26457
	ENSG00000130304
	ENSMUSG00000031808
	Q6PCB7
	Q60714
	NM_198580
	NM_011977; NM_001357180; NM_001357181; NM_001357182
	NP_940982
	NP_036107; NP_001344109; NP_001344110; NP_001344111
	Wikidata
View/Edit Human	View/Edit Mouse

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Revision as of 19:18, 5 June 2016

Long-chain fatty acid transport protein 1 is a protein that in humans is encoded by the SLC27A1 gene.^[5]^[6]

Template:PBB Summary

Structure

The SLC27A1 gene is located on the 19th chromosome, with its specific location being 19p13.11. The gene contains 15 exons.^[6] SLC27A1 encodes a 71.1 kDa protein that is composed of 646 amino acids; 26 peptides have been observed through mass spectrometry data.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000130304 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031808 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Martin G; Nemoto M; Gelman L; Geffroy S; Najib J; Fruchart JC; Roevens P; de Martinville B; Deeb S; Auwerx J (Sep 2000). "The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression". Genomics. 66 (3): 296–304. doi:10.1006/geno.2000.6191. PMID 10873384.
^ ^a ^b "Entrez Gene: SLC27A1 solute carrier family 27 (fatty acid transporter), member 1".
^ ]Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
^ "Long-chain fatty acid transport protein 1". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).

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 {{Infobox_gene}}
-'''Long-chain fatty acid transport protein 1''' is a [[protein]] that in humans is encoded by the ''SLC27A1'' [[gene]].<ref name="pmid10873384">{{cite journal | author = Martin G, Nemoto M, Gelman L, Geffroy S, Najib J, Fruchart JC, Roevens P, de Martinville B, Deeb S, Auwerx J | title = The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression | journal = Genomics | volume = 66 | issue = 3 | pages = 296–304 |date=Sep 2000 | pmid = 10873384 | pmc =  | doi = 10.1006/geno.2000.6191 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC27A1 solute carrier family 27 (fatty acid transporter), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=376497| accessdate = }}</ref>
+'''Long-chain fatty acid transport protein 1''' is a [[protein]] that in humans is encoded by the ''SLC27A1'' [[gene]].<ref name="pmid10873384">{{cite journal |author1=Martin G |author2=Nemoto M |author3=Gelman L |author4=Geffroy S |author5=Najib J |author6=Fruchart JC |author7=Roevens P |author8=de Martinville B |author9=Deeb S |author10=Auwerx J | title = The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression | journal = Genomics | volume = 66 | issue = 3 | pages = 296–304 |date=Sep 2000 | pmid = 10873384 | pmc =  | doi = 10.1006/geno.2000.6191 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC27A1 solute carrier family 27 (fatty acid transporter), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=376497| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
@@ Line 22: / Line 22: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Meirhaeghe A, Cottel D, Amouyel P, Dallongeville J |title=Lack of association between certain candidate gene polymorphisms and the metabolic syndrome. |journal=Mol. Genet. Metab. |volume=86 |issue= 1–2 |pages= 293–9 |year= 2006 |pmid= 15978856 |doi= 10.1016/j.ymgme.2005.05.006 }}
+*{{cite journal  |author1=Meirhaeghe A |author2=Cottel D |author3=Amouyel P |author4=Dallongeville J |title=Lack of association between certain candidate gene polymorphisms and the metabolic syndrome. |journal=Mol. Genet. Metab. |volume=86 |issue= 1–2 |pages= 293–9 |year= 2006 |pmid= 15978856 |doi= 10.1016/j.ymgme.2005.05.006 }}
 *{{cite journal  | author=García-Martínez C |title=Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells |journal=Am. J. Physiol., Cell Physiol. |volume=288 |issue= 6 |pages= C1264–72 |year= 2005 |pmid= 15897321 |doi= 10.1152/ajpcell.00271.2004  |name-list-format=vanc| author2=Marotta M  | author3=Moore-Carrasco R  | display-authors=3  | last4=Guitart  | first4=M  | last5=Camps  | first5=M  | last6=Busquets  | first6=S  | last7=Montell  | first7=E  | last8=Gómez-Foix  | first8=AM }}
 *{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
@@ Line 28: / Line 28: @@
 *{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
 *{{cite journal  | author=Hatch GM |title=FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells |journal=J. Lipid Res. |volume=43 |issue= 9 |pages= 1380–9 |year= 2003 |pmid= 12235169 |doi=10.1194/jlr.M200130-JLR200  |name-list-format=vanc| author2=Smith AJ  | author3=Xu FY  | display-authors=3  | last4=Hall  | first4=AM  | last5=Bernlohr  | first5=DA  }}
-*{{cite journal  | author=Hirsch D, Stahl A, Lodish HF |title=A family of fatty acid transporters conserved from mycobacterium to man |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 15 |pages= 8625–9 |year= 1998 |pmid= 9671728 |doi=10.1073/pnas.95.15.8625  | pmc=21126  }}
+*{{cite journal  |author1=Hirsch D |author2=Stahl A |author3=Lodish HF |title=A family of fatty acid transporters conserved from mycobacterium to man |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 15 |pages= 8625–9 |year= 1998 |pmid= 9671728 |doi=10.1073/pnas.95.15.8625  | pmc=21126  }}
-*{{cite journal  | author=Schaffer JE, Lodish HF |title=Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein |journal=Cell |volume=79 |issue= 3 |pages= 427–36 |year= 1994 |pmid= 7954810 |doi=10.1016/0092-8674(94)90252-6  }}
+*{{cite journal  |author1=Schaffer JE |author2=Lodish HF |title=Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein |journal=Cell |volume=79 |issue= 3 |pages= 427–36 |year= 1994 |pmid= 7954810 |doi=10.1016/0092-8674(94)90252-6  }}
 }}
 {{refend}}

Long-chain fatty acid transport protein 1: Difference between revisions

Revision as of 19:18, 5 June 2016

Structure

See also

References

Further reading