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The '''''SLC10A2''''' (solute carrier family 10 member 2) [[gene]] in humans encodes the [[bile acid:sodium symporter]] known as the '''apical sodium–bile acid transporter''' (ASBT) or as the '''ileal bile acid transporter''' (IBAT).<ref name="pmid8661017">{{cite journal | vauthors = Wong MH, Rao PN, Pettenati MJ, Dawson PA | title = Localization of the ileal sodium-bile acid cotransporter gene (SLC10A2) to human chromosome 13q33 | journal = Genomics | volume = 33 | issue = 3 | pages = 538–40 | date = May 1996 | pmid = 8661017 | pmc = | doi = 10.1006/geno.1996.0233 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6555| accessdate = }}</ref>
The '''''SLC10A2''''' (solute carrier family 10 member 2) [[gene]] in humans encodes the [[bile acid:sodium symporter]] known as the '''apical sodium–bile acid transporter''' (ASBT) or as the '''ileal bile acid transporter''' (IBAT).<ref name="pmid8661017">{{cite journal | vauthors = Wong MH, Rao PN, Pettenati MJ, Dawson PA | title = Localization of the ileal sodium-bile acid cotransporter gene (SLC10A2) to human chromosome 13q33 | journal = Genomics | volume = 33 | issue = 3 | pages = 538–40 | date = May 1996 | pmid = 8661017 | pmc = | doi = 10.1006/geno.1996.0233 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6555| accessdate = }}</ref>


ASBT/IBAT is most highly expressed in the [[ileum]], where it is found on the [[brush border]] membrane of [[enterocyte]]s. It is responsible for the initial uptake of bile acids, particularly conjugated bile acids, from the intestine as part of their [[enterohepatic circulation]].<ref name="pmid21103970">{{cite journal | vauthors = Dawson PA | title = Role of the intestinal bile acid transporters in bile acid and drug disposition | journal = Handbook of Experimental Pharmacology | volume = | issue = 201 | pages = 169–203 | year = 2011 | pmid = 21103970 | pmc = 3249407 | doi = 10.1007/978-3-642-14541-4_4 }}</ref>
ASBT/IBAT is most highly expressed in the [[ileum]], where it is found on the [[brush border]] membrane of [[enterocyte]]s. It is responsible for the initial uptake of bile acids, particularly conjugated bile acids, from the intestine as part of their [[enterohepatic circulation]].<ref name="pmid21103970">{{cite journal | vauthors = Dawson PA | title = Role of the intestinal bile acid transporters in bile acid and drug disposition | journal = Handbook of Experimental Pharmacology | volume = | issue = 201 | pages = 169–203 | year = 2011 | pmid = 21103970 | pmc = 3249407 | doi = 10.1007/978-3-642-14541-4_4 }}</ref>

Revision as of 06:25, 11 September 2017

SLC10A2
Identifiers
AliasesSLC10A2, ASBT, IBAT, ISBT, NTCP2, PBAM, solute carrier family 10 member 2, Ileal bile acid transporter, PBAM1
External IDsOMIM: 601295; MGI: 1201406; HomoloGene: 390; GeneCards: SLC10A2; OMA:SLC10A2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

6555

20494

Ensembl

ENSG00000125255

ENSMUSG00000023073

UniProt

Q12908

P70172

RefSeq (mRNA)

NM_000452

NM_011388

RefSeq (protein)

NP_000443

NP_035518

Location (UCSC)Chr 13: 103.04 – 103.07 MbChr 8: 5.13 – 5.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The SLC10A2 (solute carrier family 10 member 2) gene in humans encodes the bile acid:sodium symporter known as the apical sodium–bile acid transporter (ASBT) or as the ileal bile acid transporter (IBAT).[5][6]

ASBT/IBAT is most highly expressed in the ileum, where it is found on the brush border membrane of enterocytes. It is responsible for the initial uptake of bile acids, particularly conjugated bile acids, from the intestine as part of their enterohepatic circulation.[7]

As a drug target

Several medications to inhibit IBAT are under development. They include elobixibat, under development for the treatment of constipation and irritable bowel syndrome,[8] and volixibat, under development for the treatment of nonalcoholic steatohepatitis.[9]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125255 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023073 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wong MH, Rao PN, Pettenati MJ, Dawson PA (May 1996). "Localization of the ileal sodium-bile acid cotransporter gene (SLC10A2) to human chromosome 13q33". Genomics. 33 (3): 538–40. doi:10.1006/geno.1996.0233. PMID 8661017.
  6. ^ "Entrez Gene: SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2".
  7. ^ Dawson PA (2011). "Role of the intestinal bile acid transporters in bile acid and drug disposition". Handbook of Experimental Pharmacology (201): 169–203. doi:10.1007/978-3-642-14541-4_4. PMC 3249407. PMID 21103970.
  8. ^ Acosta A, Camilleri M (July 2014). "Elobixibat and its potential role in chronic idiopathic constipation". Therapeutic Advances in Gastroenterology. 7 (4): 167–75. doi:10.1177/1756283X14528269. PMC 4107709. PMID 25057297.
  9. ^ Chitnis, Deepak (2016-08-03), "FDA grants fast track status to volixibat", Internal Medicine News Digital Network, retrieved 2016-08-14. {{citation}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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