Zinc transporter 1: Difference between revisions
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'''Solute carrier family 30 (zinc transporter), member 1''' is a [[protein]] which in humans is encoded by the '''''SLC30A1''''' [[gene]].<ref name="pmid7882967">{{cite journal | author = Palmiter RD, Findley SD | title = Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc | journal = The EMBO |
'''Solute carrier family 30 (zinc transporter), member 1''' is a [[protein]] which in humans is encoded by the '''''SLC30A1''''' [[gene]].<ref name="pmid7882967">{{cite journal | author = Palmiter RD, Findley SD | title = Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc | journal = The EMBO Journal | volume = 14 | issue = 4 | pages = 639–49 | year = 1995 | month = February | pmid = 7882967 | pmc = 398127 | doi = | url = | issn = }}</ref><ref name="pmid15154973">{{cite journal | author = Seve M, Chimienti F, Devergnas S, Favier A | title = In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression | journal = BMC Genomics | volume = 5 | pages = 32 | year = 2004 | month = May | pmid = 15154973 | pmc = 428573 | doi = 10.1186/1471-2164-5-32 | url = | issn = | issue=1}}</ref> |
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==Function== |
==Function== |
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SLC30A1 modulates zinc permeation through the [[L-type calcium channel]]. SLC30A1 downregulates not only Zn<sup>++</sup> influx, but also Ca<sup>++</sup> influx, thereby protecting cells from the effects of excessive cation permeation.<ref name="pmid15451416">{{cite journal | author = Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I | title = A role for ZnT-1 in regulating cellular cation influx | journal = Biochemical and |
SLC30A1 modulates zinc permeation through the [[L-type calcium channel]]. SLC30A1 downregulates not only Zn<sup>++</sup> influx, but also Ca<sup>++</sup> influx, thereby protecting cells from the effects of excessive cation permeation.<ref name="pmid15451416">{{cite journal | author = Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I | title = A role for ZnT-1 in regulating cellular cation influx | journal = Biochemical and Biophysical Research Communications | volume = 323 | issue = 4 | pages = 1145–50 | year = 2004 | month = October | pmid = 15451416 | doi = 10.1016/j.bbrc.2004.08.211 | url = | issn = }}</ref> |
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==References== |
==References== |
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Revision as of 09:05, 13 April 2012
Solute carrier family 30 (zinc transporter), member 1 is a protein which in humans is encoded by the SLC30A1 gene.[1][2]
Function
SLC30A1 modulates zinc permeation through the L-type calcium channel. SLC30A1 downregulates not only Zn++ influx, but also Ca++ influx, thereby protecting cells from the effects of excessive cation permeation.[3]
References
- ^ Palmiter RD, Findley SD (1995). "Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc". The EMBO Journal. 14 (4): 639–49. PMC 398127. PMID 7882967.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ Seve M, Chimienti F, Devergnas S, Favier A (2004). "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression". BMC Genomics. 5 (1): 32. doi:10.1186/1471-2164-5-32. PMC 428573. PMID 15154973.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I (2004). "A role for ZnT-1 in regulating cellular cation influx". Biochemical and Biophysical Research Communications. 323 (4): 1145–50. doi:10.1016/j.bbrc.2004.08.211. PMID 15451416.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)
Further reading
- Guey LT, GarcÃa-Closas M, Murta-Nascimento C; et al. (2009). "Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes". Eur. Urol. 57 (2): HASH(0x24ec9d0). doi:10.1016/j.eururo.2009.08.001. PMID 19692168.
{{cite journal}}: Explicit use of et al. in:|author=(help); soft hyphen character in|author=at position 15 (help)CS1 maint: multiple names: authors list (link) - Zhang LH, Wang X, Stoltenberg M; et al. (2008). "Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain". Brain Res. Bull. 77 (1): 55–60. doi:10.1016/j.brainresbull.2008.03.014. PMID 18639746.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Lovell MA, Smith JL, Xiong S, Markesbery WR (2005). "Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease". Neurotoxicity research. 7 (4): 265–71. doi:10.1007/BF03033884. PMID 16179263.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Zhang LY, Wang XL, Sun DX; et al. (2008). "Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts". Mol. Biol. Rep. 35 (4): 595–600. doi:10.1007/s11033-007-9129-8. PMID 17786585.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Iguchi K, Otsuka T, Usui S; et al. (2004). "Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells". J. Androl. 25 (1): 154–61. PMID 14662799.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Lazarczyk M, Pons C, Mendoza JA; et al. (2008). "Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses". J. Exp. Med. 205 (1): 35–42. doi:10.1084/jem.20071311. PMC 2234378. PMID 18158319.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Overbeck S, Uciechowski P, Ackland ML; et al. (2008). "Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9". J. Leukoc. Biol. 83 (2): 368–80. doi:10.1189/jlb.0307148. PMID 17971500.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Hosgood HD, Menashe I, He X; et al. (2009). "PTEN identified as important risk factor of chronic obstructive pulmonary disease". Respiratory medicine. 103 (12): HASH(0x15616e0). doi:10.1016/j.rmed.2009.06.016. PMC 2783799. PMID 19625176.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Hosgood HD, Menashe I, Shen M; et al. (2008). "Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway". Carcinogenesis. 29 (10): 1938–43. doi:10.1093/carcin/bgn178. PMC 2722857. PMID 18676680.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Etzion Y, Ganiel A, Beharier O; et al. (2008). "Correlation between atrial ZnT-1 expression and atrial fibrillation in humans: a pilot study". J. Cardiovasc. Electrophysiol. 19 (2): 157–64. doi:10.1111/j.1540-8167.2007.01008.x. PMID 17971132.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - Barbe L, Lundberg E, Oksvold P; et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
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