2,2′-methylenebis (4-methyl-6- tert- butylphenol)

Structural formula
General
Surname	2,2′-methylenebis (4-methyl-6- tert- butylphenol)
other names	2,2'-dihydroxy-3,3'- di- tert- butyl-5,5'-dimethyldiphenylmethane; 2,2′-methylenebis (6- tert -butyl-4-methylphenol); Vulkanox BKF; Anti ox;
Molecular formula	C 23 H 32 O 2
Brief description	light yellow, odorless, crystalline powder
External identifiers / databases
EC number	204-327-1
ECHA InfoCard	100.003.934
PubChem	8398
Wikidata	Q16830225
properties
Molar mass	340.50 g mol −1
Physical state	firmly
density	1.07 g cm −3
Melting point	123-127 ° C
solubility	practically insoluble in water
safety instructions
GHS labeling of hazardous substances Caution
H and P phrases	H: 361f
	P: 201-202-281
Toxicological data	4880 mg kg −1 ( LD 50 , rat , oral )
	As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

2,2'-methylenebis (4-methyl-6- tert- butylphenol) is an antioxidant from the group of bisphenols . As an anti-aging agent , it stabilizes elastomers , rubber , paints and polymers.

Safety instructions / toxicology

In 2016, 2,2′-methylenebis (4-methyl-6- tert- butylphenol) was included in the Community's ongoing action plan ( CoRAP ) in accordance with Regulation (EC) No. 1907/2006 (REACH) as part of substance evaluation . The effects of the substance on human health and the environment are re-evaluated and, if necessary, follow-up measures are initiated. The reason for the uptake of 2,2′-methylenebis (4-methyl-6- tert- butylphenol) were concerns about the possible risk of reproductive toxicity and as a potential endocrine disruptor. The re-evaluation took place from 2016 and was carried out by Denmark . A final report was then published.

Individual evidence

↑ ^a ^b ^c ^d ^e Entry on 2,2′-methylenebis (4-methyl-6-tert-butylphenol) in the GESTIS substance database of the IFA , accessed on January 8, 2018(JavaScript required) .
↑ Data sheet 2,2′-methylenebis (6-tert-butyl-4-methylphenol) from Sigma-Aldrich , accessed on April 20, 2014 ( PDF ).
↑ Data sheet 2,2′-methylenebis (4-methyl-6-tert-butylphenol) (PDF) from Merck , accessed on April 20, 2014.
↑ European Chemicals Agency (ECHA): Substance Evaluation Conclusion and Evaluation Report
↑ Community rolling action plan ( CoRAP ) of the European Chemicals Agency (ECHA): 6,6′-di-tert-butyl-2,2′-methylenedi-p-cresol , accessed on March 26, 2019.

[GESTIS-1] Entry on 2,2′-methylenebis (4-methyl-6-tert-butylphenol) in the GESTIS substance database of the IFA , accessed on January 8, 2018(JavaScript required) .

[Sigma-2] Data sheet 2,2′-methylenebis (6-tert-butyl-4-methylphenol) from Sigma-Aldrich , accessed on April 20, 2014 ( PDF ).

[3] Data sheet 2,2′-methylenebis (4-methyl-6-tert-butylphenol) (PDF) from Merck , accessed on April 20, 2014.

[4] European Chemicals Agency (ECHA): Substance Evaluation Conclusion and Evaluation Report

[5] Community rolling action plan ( CoRAP ) of the European Chemicals Agency (ECHA): 6,6′-di-tert-butyl-2,2′-methylenedi-p-cresol , accessed on March 26, 2019.