3- (trifluoromethyl) phenol

Structural formula
General
Surname	3- (trifluoromethyl) phenol
other names	3-hydroxybenzotrifluoride α, α, α-trifluoro- m -cresol
Molecular formula	C 7 H 5 F 3 O
Brief description	yellow liquid
External identifiers / databases
CAS number 98-17-9 EC number 202-645-5 ECHA InfoCard 100.002.405 PubChem 7376 Wikidata Q72512198
properties
Molar mass	162.11 g mol −1
Physical state	liquid
density	1.336 g cm −3
Melting point	−2 ° C
boiling point	177-178 ° C
solubility	practically insoluble in water
Refractive index	1.4580 (20 ° C)
safety instructions
GHS labeling of hazardous substances danger H and P phrases H: 302-314-412 P: 301 + 330 + 331-305 + 351 + 338
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

3- (Trifluoromethyl) phenol is a chemical compound of fluorine from the group of phenol derivatives .

Extraction and presentation

Starting from (trifluoromethyl) benzene , nitration gives the meta-nitro isomer as the main product, which can be converted into 3- (trifluoromethyl) aniline by reduction . 3- (Trifluoromethyl) phenol can be obtained by diazotizing 3- (trifluoromethyl) aniline and then boiling the diazonium salt .

properties

3- (Trifluoromethyl) phenol is a yellow liquid that is practically insoluble in water.

use

3- (Trifluoromethyl) phenol is used in the manufacture of the anti- glaucoma drug Travoprost .

Individual evidence

1. ↑ ^{a b c d e f g h i j} Data sheet 3- (Trifluoromethyl) phenol, 98 +% from AlfaAesar, accessed on December 8, 2019 ( PDF )(JavaScript required) .
2. ^ RE Banks, BE Smart, JC Tatlow: Organofluorine Chemistry Principles and Commercial Applications . Springer Science & Business Media, 2013, ISBN 978-1-4899-1202-2 , pp. 225 ff . ( limited preview in Google Book search).
3. ↑ Data sheet 3- (Trifluoromethyl) phenol, 99% from Sigma-Aldrich , accessed on December 8, 2019 ( PDF ).