ABCG1

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ATP-binding cassette sub-family G member 1
Properties of human protein
Mass / length primary structure 678 amino acids
Secondary to quaternary structure Heterodimer
Isoforms 8th
Identifier
Gene name ABCG1
External IDs
Transporter classification
TCDB 3.A.1.204.1
designation ABCG subfamily
Occurrence
Parent taxon Mammals
Orthologue
human House mouse
Entrez 9619 11307
Ensemble ENSG00000160179 ENSMUSG00000024030
UniProt P45844 Q64343
Refseq (mRNA) NM_004915 NM_009593
Refseq (protein) NP_004906 NP_033723
Gene locus Chr 21: 42.2 - 42.3 Mb Chr 17: 31.06 - 31.12 Mb
PubMed search 9619 11307

ABCG1 is one of two proteins in the cell membrane of mammals that pumps cholesterol out of the cell using ATP , where it floats on the membrane and is taken up by HDL particles ( reverse cholesterol transport ). It belongs to the ABC transporter family . Oxidation products of cholesterol accumulate in mouse endothelial cells without ABCG1. ABCG1 also plays the main role in cholesterol transport in macrophages and monocytes . In other cells this is taken over by ABCA 1 .

In type 2 diabetes mellitus patients, the expression of ABCG1 in monocytes is reduced, which contributes to atherosclerosis , similar to the activity of the enzyme 12/15 lipoxygenase . However, overexpression leads  to apoptosis via translocation of phosphatidylserine and caspase 3 activation .

Individual evidence

  1. ↑ Homologues at OMA
  2. ↑ UniProt P45844
  3. ↑ Terasaka N, Yu S, Yvan-Charvet L, et al. : ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet . In: J. Clin. Invest. . 118, No. 11, November 2008, pp. 3701-13. doi : 10.1172 / JCI35470 . PMID 18924609 . PMC 2567835 (free full text).
  4. ↑ Zhou H, Tan KC, Shiu SW, Wong Y: Determinants of leukocyte adenosine triphosphate-binding cassette transporter G1 gene expression in type 2 diabetes mellitus . In: Metab. Clin. Exp. . 57, No. 8, August 2008, pp. 1135-40. doi : 10.1016 / j.metabol.2008.03.020 . PMID 18640393 .
  5. ↑ Mauldin JP, Nagelin MH, Wojcik AJ, et al. : Reduced expression of ATP-binding cassette transporter G1 increases cholesterol accumulation in macrophages of patients with type 2 diabetes mellitus . In: Circulation . 117, No. 21, May 2008, pp. 2785-92. doi : 10.1161 / CIRCULATIONAHA.107.741314 . PMID 18490524 .
  6. ↑ Nagelin MH, Srinivasan S, Lee J, Nadler JL, Hedrick CC: 12/15 Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1 . In: Arterioscler. Thromb. Vasc. Biol . 28, No. 10, October 2008, pp. 1811-9. doi : 10.1161 / ATVBAHA.108.167908 . PMID 18635820 .
  7. ↑ Seres L, Cserepes J, Elkind NB, et al. : Functional ABCG1 expression induces apoptosis in macrophages and other cell types . In: Biochim. Biophys. Acta . 1778, No. 10, October 2008, pp. 2378-87. doi : 10.1016 / j.bbamem.2008.06.010 . PMID 18619413 .

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