4- (2-aminoethyl) benzenesulfonyl fluoride

Structural formula
General
Surname	4- (2-aminoethyl) benzenesulfonyl fluoride
other names	AEBSF
Molecular formula	C 8 H 10 FNO 2 S
Brief description	white solid
External identifiers / databases
CAS number 34284-75-8 30827-99-7 ( hydrochloride ) PubChem 1701 ChemSpider 1638 DrugBank DB07347 Wikidata Q290992
properties
Molar mass	203.24 g mol −1 239.70 g mol −1 (as HCl)
Physical state	firmly
Melting point	175–177 ° C (as hydrochloride)
solubility	poor in water (10 g l −1 at 20 ° C as hydrochloride)
safety instructions
GHS labeling of hazardous substances danger H and P phrases H: 314 P: 280-305 + 351 + 338-310
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions .

4- (2-Aminoethyl) benzenesulfonyl fluoride (trade name of the hydrochloride: Pefabloc SC ^® ), a water-soluble serine proteinase inhibitor. It inhibits proteases such as chymotrypsin , kallikrein , plasmin , thrombin and trypsin .

The compound has a similar spectrum of activity as phenylmethylsulfonyl fluoride (PMSF), but is much more stable , especially at low pH values . Solutions with a concentration of 0.1 to 1 mM are typically used.

Individual evidence

1. ↑ ^{a b c} data sheet 4- (2-aminoethyl) benzenesulfonyl fluoride (PDF) from Carl Roth , accessed on December 14, 2010.
2. ↑ ^{a b} Data sheet 4- (2-Aminoethyl) benzenesulfonyl fluoride hydrochloride from Sigma-Aldrich , accessed on March 18, 2011 ( PDF ).