Aleksander S. Popel

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Aleksander S. Popel (born October 8, 1945 in Moscow ) is professor of biomedical engineering at the Johns Hopkins University in Baltimore .

Career

Popel obtained a Master of Science (1967) and later (1972) Ph.D. from Lomonosov University in Moscow. In 1975 he came to the United States . His stations in the USA were Tulane University in New Orleans , the University of Arizona in Tucson and the University of Houston , before he joined Johns Hopkins University as an associate professor in 1984 and took up a chair there in 1988. From 2003 to 2004 he was visiting professor at the Department of Mechanical Engineering, the Massachusetts Institute of Technology and the Department of Pathology / Ophthalmology at Harvard . In 2009 he was visiting professor at the Newton Institute at Cambridge University . Since 2010 he has been Professor of Biomedical Engineering at Johns Hopkins University. His main research area is molecular systems biology . In addition to the By editor shank of scientific journals is another activity among many others as Chairman of the Supervisory Committee of the Biomedical Engineering Society (BMES), the leading biomedical engineering profession union in the United States.

Publications (selection)

  • Corban G. Rivera, Sofie Mellberg, Lena Claesson-Welsh, Joel S. Bader, Aleksander S. Popel: Analysis of VEGF-A Regulated Gene Expression in Endothelial Cells to Identify Genes Linked to Angiogenesis . In: PLoS One . September 13, 2011, doi : 10.1371 / journal.pone.0024887 .
  • Esak Lee, Elena V. Rosca, Niranjan B. Pandey, Aleksander S. Popel: Small peptides derived from somatotropin domain-containing proteins inhibit blood and lymphatic endothelial cell proliferation, migration, adhesion and tube formation . In: International Journal of Biochemistry & Cell Biology . tape 43 , no. December 12 , 2011, p. 1812-1821 .
  • Elena V. Rosca, Jacob E. Koskimaki, Niranjan B. Pandey, Antonio C. Wolff, Aleksander S. Popel: Development of a biomimetic peptide derived from collagen IV with anti-angiogenic activity in breast cancer . In: Cancer Biol Ther. tape 12 , no. 9 , November 2011, p. 808-817 , doi : 10.4161 / cbt.12.9.17677 .
  • Corban G. Rivera, Elena V. Rosca, Niranjan B. Pandey, Jacob E. Koskimaki, Joel S. Bader, Aleksander S. Popel: Novel Peptide-Specific Quantitative Structure-Activity Relationship (QSAR) Analysis Applied to Collagen IV Peptides with Antiangiogenic Activity . In: J Med Chem. Volume 54 , no. October 19 , 2011, p. 6492-6500 , doi : 10.1021 / jm200114f .
  • Corban G. Rivera, Joel S. Bader, Aleksander S. Popel: Angiogenesis-associated crosstalk between collagens, CXC chemokines, and thrombospondin domain-containing proteins . In: Ann Biomed Eng. tape 39 , no. 8 , August 2011, p. 2213–2222 , doi : 10.1007 / s10439-011-0325-2 .
  • Prakash Vempati, Aleksander S. Popel, Feilim Mac Gabhann: Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis . In: BMC Syst Biol. May 2011, doi : 10.1186 / 1752-0509-5-59 .
  • Elena V. Rosca, Jacob E. Koskimaki, Corban G. Rivera, Niranjan B. Pandey, Amir P. Tamiz, Aleksander S. Popel: Anti-angiogenic peptides for cancer therapeutics . In: Curr Pharm Biotechnol . tape 12 , no. 8 , August 2011, p. 1101-1116 .
  • Gang Liu, Amina A. Qutub, Prakash Vempati, Feilim Mac Gabhann, Aleksander S. Popel: Module-based multiscale simulation of angiogenesis in skeletal muscle . In: Theor Biol Med Model . April 2011, doi : 10.1186 / 1742-4682-8-6 .
  • Marianne O. Stefanini, Amina A. Qutub, Feilim Mac Gabhann, Aleksander S. Popel: Computational models of VEGF-associated angiogenic processes in cancer . In: Math Med Biol. Volume 29 , no. 1 , March 2012, p. 85-94 , doi : 10.1093 / imammb / dqq025 .
  • Polyxeni Gkontra, Magdalena M. Zak, Kerri-Ann Norton, Andrés Santos, Aleksander S. Popel, Alicia G. Arroyo: A 3D Fractal-Based Approach towards Understanding Changes in the Infarcted Heart Microvasculature . In: Nassir Navab, Joachim Hornegger , William M. Wells, Alejandro F. Frangi (Eds.): Medical Image Computing and Computer-Assisted Intervention - MICCAI 2015 . 18th International Conference, Munich, Germany, October 5-9, 2015, Proceedings, Part III. Springer International Publishing, Basel 2015, ISBN 978-3-319-24573-7 , pp. 173-180 , doi : 10.1007 / 978-3-319-24574-4 .
  • Chen Zhao, Aleksander S. Popel: Computational Model of MicroRNA Control of HIF-VEGF Pathway: Insights into the Pathophysiology of Ischemic Vascular Disease and Cancer . In: Jeffrey J. Saucerman (Ed.): PLoS Computational Biology . A peer-reviewed open access journal. No. 11/2015 . Charlottesville November 20, 2015, doi : 10.1371 / 1004612 .
  • Hojjat Bazzazi, Aleksander S. Popel: Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1 / 2 activation downstream of VEGFR2 in endothelial cells . In: Scott L. Diamond (Ed.): PLoS Computational Biology . A peer-reviewed open access journal. Philadelphia February 8, 2017, doi : 10.1371 / 1005332 .
  • Chen Zhao, Jeffrey S. Isenberg, Aleksander S. Popel: Transcriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model . In: Jeffrey J. Saucerman (Ed.): PLoS Computational Biology . A peer-reviewed open access journal. Charlottesville January 3, 2017, doi : 10.1371 / 1005272 .
  • Kerri-Ann Norton, Travis Wallace, Niranjan B. Pandey, Aleksander S. Popel: An agent-based model of triple-negative breast cancer: the interplay between chemokine receptor CCR5 expression, cancer stem cells, and hypoxia . In: BioMed Central (Ed.): BMC Systems Biology . Springer Nature, Berlin July 11, 2017, doi : 10.1186 / s12918-017-0445-X .

Web links

Individual evidence

  1. ↑ a b c Aleksander S. Popel. Engineering educator. Background. In: prabook.com. World Biographical Encyclopedia, accessed May 23, 2019 .
  2. ↑ a b Aleksander S. Popel, Ph.D. Director, Systems Biology Laboratory. Professor of Biomedical Engineering. In: hopkinsmedicine.org. Retrieved May 23, 2019 .
personal data
SURNAME Popel, Aleksander S.
BRIEF DESCRIPTION Russian-American university professor, professor of biomedical engineering
DATE OF BIRTH October 8, 1945
PLACE OF BIRTH Moscow