Andreas Engel (biophysicist)

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Andreas Engel (2009)

Andreas Engel (born October 6, 1943 in Bern ) is a Swiss structural biologist and co-founder of the Maurice E. Müller Institute for Structural Biology at the Biozentrum of the University of Basel .

Life

Andreas Engel studied physics and mathematics at the University of Bern and received his doctorate there in 1972. After a stay at the Johns Hopkins University in Baltimore, he came to the Biozentrum. There he was appointed professor for structural biology in 1986 and founded the Maurice E. Müller Institute for structural biology together with Ueli Aebi . After his retirement in 2010, Engel went to Case Western Reserve University to set up the Cleveland Center for Membrane and Structural Biology. He is currently working in the Bionanoscience Department of the Technical University of Delft .

Act

Andreas Engel did pioneering work in the application of transmission scanning electrons (STEM) and atomic force microscopy (AFM) to represent biomolecular complexes. With mass measurements using STEM, electron crystallography and AFM, he studied the structure of supramolecular complexes. Bacterial envelopes as well as molecular machines of virulent pathogens were the aim of the analyzes. Engel and Yoshinori Fujiyoshi, together with Peter Agre, also clarified the structure of the channel protein aquaporin-1. Engel's team and Krzysztof Palczewski were able to show how rhodopsin is arranged in the retina. Engel also developed the first course in nanosciences, which attracted many young talents to the University of Basel. Similar programs were later established at other top universities.

Awards

Publications (selection)

  • A. Engel: Molecular Weight Determination by Scanning Transmission Electron Microscopy. In: Ultramicroscopy. Volume 3, 1978, pp. 273-281. PMID 734784
  • A. Engel, A. Massalski, H. Schindler, DL Dorset, JP Rosenbusch: Porin channel triplets merge into single outlets in Escherichia coli outer membranes. In: Nature . Volume 317, 1985, pp. 643-645. PMID 2997617
  • FA Schabert, C. Henn, A. Engel: Native Escherichia coli OmpF Porin Surfaces Probed by the Atomic Force Microscopy. In: Science . Volume 268, 1995, pp. 92-94. PMID 7701347
  • K. Murata, K. Mistuoka, T. Hirai, T. Walz, P. Agreements, JB Heymann, A. Engel, Y. Fujiyoshi: Structural determinants of water permeation through aquaporin-1. In: Nature . Volume 407, 2000, pp. 599-605. PMID 11034202
  • D. Fotiadis, Y. Liang, S. Filipek, DA Saperstein, A. Engel, K. Palczewski: Atomic-force microscopy: Rhodopsin dimers in native disc membranes. In: Nature . Volume 421, 2003, pp. 127-128. PMID 12520290

Web links

Individual evidence

  1. ↑ Shirley A. Müller, Andreas Engel: Looking back at a quarter-century of research at the Maurice E. Müller Institute for Structural Biology. In: Journal of Structural Biology. Volume 177, No. 1, January 2012, pp. 3–13, doi: 10.1016 / j.jsb.2011.11.013 , accessed on June 18, 2014
  2. ^ Farewell symposium for Prof. Andreas Engel , February 14, 2011, accessed on March 25, 2014
  3. ↑ Andreas Engel, Ph.D. , Case Western Reserve University, accessed March 25, 2014
  4. ↑ Prof. Andreas Engel ( Memento of the original dated February 11, 2015 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. , TU Delft, People Bionanoscience Department, accessed February 11, 2015 @1@ 2Template: Webachiv / IABot / www.tnw.tudelft.nl
  5. ↑ Peter Agre, Landon S. King, Masato Yasui, Wm B. Guggino, Ole Petter Ottersen, Yoshinori Fujiyoshi, Andreas Engel and Søren Nielsen: Aquaporin water channels - from atomic structure to clinical medicine. In: The Journal of Physiology . Volume 542, No. 1, July 2002, pp. 3-16, doi: 10.1113 / jphysiol.2002.020818 , online , accessed June 18, 2014
  6. ↑ Dimitrios Fotiadis, Beata Jastrzebska, Ansgar Philippsen, Daniel J. Müller, Krzysztof Palczewski and Andreas Engel: Structure of the rhodopsin dimer: a working model for G-protein-coupled receptors. In: Current opinion in structural biology. Volume 16, No. 2, April 2006, pp. 252-259, doi: 10.1016 / j.sbi.2006.03.013 , PDF , accessed on June 18, 2014
  7. ↑ Honorary doctor: Andreas Engel ( Memento of the original from March 4, 2014 in the Internet Archive ) Info: The archive link was inserted automatically and has not yet been checked. Please check the original and archive link according to the instructions and then remove this notice. , Aarhus University, accessed March 25, 2014 @1@ 2Template: Webachiv / IABot / www.au.dk
personal data
SURNAME Engel, Andreas
BRIEF DESCRIPTION Swiss structural biologist
DATE OF BIRTH October 6, 1943
PLACE OF BIRTH Bern