Bruce Ames

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Bruce Ames

Bruce Nathan Ames (born December 16, 1928 in New York City ) is an American professor of biochemistry and molecular biology , researcher at the Children's Hospital of Oakland Research Institute (CHORI) and was director of the "National Institute of Environmental Health Science" from the University of California, Berkeley . He researched the link between folic acid deficiency and damage to DNA and chromosomes , which can lead to cancer and other diseases. In the 1970s, Ames invented the Ames test named after him .

job

In 1971, Ames succeeded in developing a test for mutagenicity that has been widely used since then (Ames test). With this he identified many carcinogenic substances, and it turned out that the structure of heterocyclic amines was often present.

Ames has been researching the relationship between the supply of micronutrients and human cell metabolism for a long time .

In a review he claims that high-dose vitamin therapy can cure or alleviate around 50 human hereditary diseases. Ames also claims that deficiencies in the supply of vitamins and minerals are responsible for the development of cancer. A lack of essential fatty acids also contributes to the acceleration of the degenerative decline.

In 1999, Ames and Tory M. Hagen founded Juvenon Inc. , a company that today sells dietary supplements both directly and through sales partners. At the same time, Ames and his wife founded the Bruce and Giovanna Ames Foundation , a foundation to which Ames shares in Juvenon Inc. were transferred and whose activities include funding scientific work with his participation. He was in management at Juvenon Inc. and is still active there today as a scientific consultant. In the past he has repeatedly given assurances that he will not receive any payment from the company.

Positioning for supplementation

Together with Joyce McCann , Meir Stampfer and Walter C. Willett , Ames wrote an open letter to the American Journal of Clinical Nutrition in 2007 , which criticized the NIH decision to only recognize evidence of efficacy based on randomized, controlled trials for preventive health supplements Studies (RCTs) are based. The authors support a general recommendation by the NIH on supplementation , even without such proof of effectiveness. Dietary supplements are cheap, available and non-toxic, so at least “good insurance”.

Awards

Ames has received more than 25 scientific awards. In 1970 he was elected to the American Academy of Arts and Sciences , in 1972 to the National Academy of Sciences . In 1983 Ames was awarded the Charles S. Mott Prize and a Gairdner Foundation International Award , the Japan Prize in 1997 , the National Medal of Science in 1998 , the American Society for Microbiology's Lifetime Achievement Award in 2001, and the Thomas Hunt Morgan in 2004 Medal honored. He belonged to the "National Cancer Advisory Board" (at the suggestion of the then US President Jimmy Carter ) and the "American Heart Association Nutrition Committee". Since 2013 Thomson Reuters has counted him among the favorites for a Nobel Prize ( Thomson Reuters Citation Laureates ) due to the number of his citations .

Publications (selection)

Web links

Individual evidence

  1. ↑ a b Vita Bruce Ames
  2. ↑ CHORI website with further details and references
  3. ↑ Japan Prize for Ames
  4. ↑ Biographical article from Journal of Biological Chemistry (English) PMID 12496254
  5. ↑ American Journal of Clinical Nutrition Vol. 75, No. 4, 616-658, April 2002 (English) PMID 11916749
  6. ↑ BN Ames, P. Wakimoto: Are Vitamin and Mineral Deficiencies a Major Cancer Risk? In: Nat. Rev. Cancer . 2, 2002, pp. 694-704. PMID 12209158
  7. ↑ J. Liu, BN Ames: Reducing mitochondrial decay with mitochondrial nutrients to delay and treat cognitive dysfunction. Review. In: Nutritional Neuroscience. 8, 2005, pp. 67-89. PMID 16053240
  8. ↑ JC McCann, BN Ames: Is docosahexaenoic acid (DHA), an n-3 long chain polyunsaturated fatty acid, required for normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals: a review. In: Am J Clin Nutr. 82, 2005, pp. 281-295. PMID 16087970
  9. ↑ Dietary Supplements Make Old Rats Youthful, May Rejuvenate Aging Humans. (No longer available online.) In: universityofcalifornia.edu. University of California February 19, 2002, archived from the original October 16, 2013 ; accessed on February 25, 2016 .
  10. ^ Juvenon Inc. - Our Story.
  11. ^ Because Lifestyle, LLC and Juvenon, Inc. Announce Partnership. In: Press Releases. Because Lifestyle LLC ( January 6, 2009 memento on the Internet Archive )
  12. ^ Juvenon Inc. - Scientific Advisory Board
  13. ^ Conflict of interest statement. In: PNAS . vol. 103, no.47, November 21, 2006. (pnas.org)
  14. ↑ National Institutes of Health State-of-the-Science Panel: National Institutes of Health State-of-the-Science Conference Statement: multivitamin / mineral supplements and chronic disease prevention. In: Am J Clin Nutr. 85 (1), Jan 2007, pp. 257S-264S. PMID 17209206 (full text)
  15. ↑ BN Ames, JC McCann, MJ Stampfer, WC Willett: Evidence-based decision making on micronutrients and chronic disease: long-term randomized controlled trials are not enough. In: Am J Clin Nutr. 86 (2), Aug 2007, pp. 522-523. PMID 17684228 (full text)
  16. ↑ Documentation on the CHORI website
  17. ↑ 2013 Predictions at Thomson Reuters (sciencewatch.com); Retrieved September 25, 2013.
personal data
SURNAME Ames, Bruce
ALTERNATIVE NAMES Ames, Bruce Nathan (full name)
BRIEF DESCRIPTION American biochemist and molecular biologist
DATE OF BIRTH December 16, 1928
PLACE OF BIRTH New York City