Butyrophenone

Structural formula
General
Surname	Butyrophenone
other names	Propyl phenyl ketone Phenyl propyl ketone 1-phenylbutan-1-one ( IUPAC )
Molecular formula	C 10 H 12 O
External identifiers / databases
CAS number 495-40-9 EC number 207-799-7 ECHA InfoCard 100.007.091 PubChem 10315 Wikidata Q421344
properties
Molar mass	148.20 g mol −1
Physical state	liquid
density	1.021 g cm −3 (25 ° C)
Melting point	11-13 ° C
boiling point	228-230 ° C
Refractive index	1.520 (20 ° C)
safety instructions
GHS labeling of hazardous substances danger H and P phrases H: 317-318 P: 280-305 + 351 + 338
As far as possible and customary, SI units are used. Unless otherwise noted, the data given apply to standard conditions . Refractive index: Na-D line , 20 ° C

Butyrophenone is an aromatic organic-chemical compound and belongs to the ketones . It is the starting compound of the butyrophenones .

It can be made by Friedel-Crafts acylation of benzene with butyryl chloride . The Lewis acid aluminum chloride  (AlCl ₃ ) acts as a catalyst .

Some of its derivatives are commonly used neuroleptics , such as haloperidol and melperone . Their effect is based on the inhibition of (D ₂ ) dopamine receptors .

Individual evidence

1. ↑ ^{a b c d e f} data sheet butyrophenone from Sigma-Aldrich , accessed on September 6, 2016 ( PDF ).
2. ↑ Axel M. Gressner, Torsten Arndt (Ed.): Lexicon of the Medical Laboratory Diagnostics . 2., revised. and exp. Edition. Springer, Berlin, Heidelberg 2013, ISBN 978-3-642-12921-6 , entry on Butyrophenone , doi : 10.1007 / 978-3-642-12921-6 .
3. ↑ Thomas Efferth: Molecular pharmacology and toxicology: biological bases of drugs and poisons . Springer, Berlin, Heidelberg 2006, ISBN 3-540-21223-X , pp. 64 .