CD molecule 38

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ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase 1
ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase 1
according to PDB  1YH3
other names

2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase / 2'-phospho-cyclic-ADP-ribose transferase, 2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, ADPRC 1, CD38

Existing structure data : PDB  1ZVM , PDB  2EF1

Properties of human protein
Mass / length primary structure 300 amino acids , 34,328 Da
External IDs
Enzyme classification
EC, category
Orthologue (human)
Entrez 952
Ensemble ENSG00000004468
UniProt P28907
Refseq (mRNA) NM_001775.3
Refseq (protein) NP_001766.2
PubMed search 952

ADP-ribosylcyclase / cADPR-hydrolase 1 (synonym CD38 ) is a surface protein from the group of hydrolases .


CD38 catalyzes the reaction of nicotinamide adenine dinucleotide (NAD) to cADP-ribose (cADPR) and back, as well as the reaction of NADP and nicotinate to nicotinic acid adenine dinucleotide phosphate and nicotinamide . cADPR is a secondary messenger substance . CD38 is glycosylated . The daratumumab antibody binds to CD38 and is being studied in the treatment of multiple myeloma . It is mainly formed in the pancreas , liver , kidneys , brain , testes and ovaries , placenta and by malignant lymphomas and neuroblastomas .

Web links

Individual evidence

  1. ^ NW van de Donk, ML Janmaat, T. Mutis, JJ Lammerts van Bueren, T. Ahmadi, AK Sasser, HM Lokhorst, PW Parren: Monoclonal antibodies targeting CD38 in hematological malignancies and beyond. In: Immunological reviews. Volume 270, number 1, March 2016, pp. 95–112, doi : 10.1111 / imr.12389 , PMID 26864107 , PMC 4755228 (free full text).